In order to evaluate quantitatively the hydrology and water resources effects of land use and land cover change (LUCC), a zonal watershed hydrological model considering land use and land cover change (ZWHM-LUCC) was developed. According to the daily rainfall, evaporation and discharge data of Wuding River Basin during 1980~2000, the parameters of the model were calibrated and verified. The results show that coefficient of water balance (R) is 1.004 and the qualified rate of annual runoff depth (DR) is86.67% during calibration period 1986~2000 and the R is 0.938 and the DR is 66.67% during calibration verification 1980~1985. The calculated results indicate that this model has good adaptability in Wuding River Basin. The different scenarios of land use/land cover were analyzed by the model, with 2000 year as base year, 13 scenarios were designed, which be helpful to study water-economy-ecology interactions and natural-social dualistic, and provide the scientific basis for Wuding river basin water and soil conservation planning and water resources planning.