Calycosin orchestrates the functions of Danggui Buxue Tang, a Chinese herbal decoction composing of Astragali Radix and Angelica Sinensis Radix: An evaluation by using calycosin-knock out herbal extract

2015 ◽  
Vol 168 ◽  
pp. 150-157 ◽  
Author(s):  
Amy Guo-wei Gong ◽  
Ning Li ◽  
Kei-man Lau ◽  
Pinky Sum-chi Lee ◽  
Lu Yan ◽  
...  
Keyword(s):  
Herbal Extract ◽  
Angelica Sinensis ◽  
Knock Out ◽  
Astragali Radix ◽  
Danggui Buxue Tang ◽  
Chinese Herbal ◽  
Herbal Decoction ◽  
Angelica Sinensis Radix

scholarly journals Chemical and Biological Assessment ofAngelicaRoots from Different Cultivated Regions in a Chinese Herbal Decoction Danggui Buxue Tang

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Wendy L. Zhang ◽  
Ken Y. Z. Zheng ◽  
Kevin Y. Zhu ◽  
Janis Y. X. Zhan ◽  
Cathy W. C. Bi ◽  
...  
Keyword(s):  
Blood Circulation ◽  
Biological Properties ◽  
Biological Assessment ◽  
Angelica Sinensis ◽  
Cell Toxicity ◽  
Astragali Radix ◽  
Danggui Buxue Tang ◽  
Chinese Herbal ◽  
Herbal Decoction ◽  
Estrogenic Properties

Roots ofAngelica sinensis(Danggui) have been used in promoting blood circulation as herbal medicine for over 2000 years in China. Another species ofAngelicaroots calledA. gigasis being used in Korea. To reveal the efficiency of differentAngelicaroots, the chemical and biological properties ofAngelicaroots from different cultivated regions were compared. Roots ofA. sinensiscontained higher levels of ferulic acid, Z-ligustilide, and senkyunolide A, while high amounts of butylphthalide and Z-butylenephthalide were found inA. gigasroots. The extracts deriving fromA. gigasroots showed better effects in osteogenic and estrogenic properties than that ofA. sinensisfrom China. However, this difference was markedly reduced when theAngelicaroots were being prepared in a Chinese herbal decoction together with Astragali Radix as Danggui Buxue Tang. In contrast, the herbal decoction prepared fromA. sinensisroots showed better responses in cell cultures. In addition, the extracts ofA. gigasroots showed strong cell toxicity both as single herb and as Danggui Buxue Tang. This result revealed the distinct properties ofAngelicaroots from China and Korea suggesting the specific usage of herb in preparing a unique herbal decoction.

Can Rhizoma Chuanxiong Replace Radix Angelica Sinensis in the Traditional Chinese Herbal Decoction Danggui Buxue Tang?

Planta Medica ◽  
2009 ◽  
Vol 75 (06) ◽  
pp. 602-606 ◽  
Author(s):  
Winnie Li ◽  
Jun Li ◽  
Cathy Bi ◽  
Anna Cheung ◽  
Wen Huang ◽  
...  
Keyword(s):  
Angelica Sinensis ◽  
Rhizoma Chuanxiong ◽  
Danggui Buxue Tang ◽  
Chinese Herbal ◽  
Herbal Decoction

scholarly journals Functions of Danggui Buxue Tang, a Chinese Herbal Decoction Containing Astragali Radix and Angelicae Sinensis Radix, in Uterus and Liver are Both Estrogen Receptor-Dependent and -Independent

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Oliver Zierau ◽  
Ken Y. Z. Zheng ◽  
Anja Papke ◽  
Tina T. X. Dong ◽  
Karl W. K. Tsim ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Ovariectomized Rats ◽  
Transcript Expression ◽  
Astragali Radix ◽  
Danggui Buxue Tang ◽  
Chinese Herbal ◽  
Herbal Decoction ◽  
Estrogenic Properties ◽  
Angelicae Sinensis

Danggui Buxue Tang (DBT), a herbal decoction containing Astragali Radix (AR) and Angelicae Sinensis Radix (ASR), has been used in treating menopausal irregularity in women for more than 800 years in China. Pharmacological results showed that DBT exhibited significant estrogenic propertiesin vitro, which therefore suggested that DBT could activate the nuclear estrogen receptors. Here, we assessed the estrogenic properties of DBT in an ovariectomizedin vivorat model: DBT was applied to the ovariectomized rats for 3 days. The application of DBT did not alter the weight of uterus and liver, as well as the transcript expression of the proliferation markers including the estrogen receptorsαandβ. However, DBT stimulated the transcript expression of the estrogen responsive genes. In addition, the inductive role of DBT on the expression of members of the aryl hydrocarbon receptor family in uterus and liver of ovariectomized rats was confirmed. These responses of DBT however were clearly distinct from the response pattern detectable here for 17β-estradiol. Therefore, DBT exhibited weak, but significant, estrogenic propertiesin vivo; however, some of its activities were independent of the estrogen receptor. Thus, DBT could be an exciting Chinese herbal decoction for an alternative treatment of hormone replacement therapy for women in menopause without subsequent estrogenic side effects.

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