Adipose derived mesenchymal stem cells along with Alpinia oxyphylla extract alleviate mitochondria-mediated cardiac apoptosis in aging models and cardiac function in aging rats

2021 ◽  
Vol 264 ◽  
pp. 113297
Author(s):  
Yung-Ming Chang ◽  
Marthandam Asokan Shibu ◽  
Chih-Sheng Chen ◽  
Shanmugam Tamilselvi ◽  
Chuan-Te Tsai ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cardiac Function ◽  
Aging Rats ◽  
Alpinia Oxyphylla ◽  
Cardiac Apoptosis ◽  
Aging Models

scholarly journals Adipose-derived mesenchymal stem cells preserve cardiac function via ANT-1 in dilated cardiomyopathy hamster model

2021 ◽  
Vol 18 ◽  
pp. 182-190
Author(s):  
Daisuke Mori ◽  
Shigeru Miyagawa ◽  
Takashi Kido ◽  
Hiroki Hata ◽  
Takayoshi Ueno ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cardiac Function ◽  
Dilated Cardiomyopathy ◽  
Hamster Model

scholarly journals Mesenchymal stem cells with overexpression of Angiotensin-converting enzyme-2 improved the microenvironment and cardiac function in a rat model of myocardial infarction

2020 ◽  
Author(s):  
Chao Liu ◽  
Yue Fan ◽  
Hong-Yi Zhu ◽  
Lu zhou ◽  
Yu Wang ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Angiotensin Converting Enzyme ◽  
Cardiac Function ◽  
Heart Function ◽  
Tube Formation ◽  
Border Zone ◽  
Converting Enzyme ◽  
Angiotensin Converting Enzyme 2

AbstractBackgroundAngiotensin-converting enzyme-2 (ACE2) overexpression improves left ventricular remodeling and function in diabetic cardiomyopathy; however, the effect of ACE2-overexpressed mesenchymal stem cells (MSCs) on myocardial infarction (MI) remains unexplored. This study aimed to investigate the effect of ACE2-overexpression on the function of MSCs and the therapeutic efficacy of MSCs for MI.MethodsMSCs were transfected with Ace2 gene using lentivirus, and then transplanted into the border zone of ischemic heart. The renin-angiotensin system (RAS) expression, nitric oxide synthase (NOS) expression, paracrine factors, anti-hypoxia ability, tube formation of MSCs, and heart function were determined.ResultsMSCs expressed little ACE2. ACE2-overexpression decreased the expression of AT1 and VEGF apparently, up-regulated the paracrine of HGF, and increased the synthesis of Angiotensin 1-7 in vitro. ACE2-overexpressed MSCs showed a cytoprotective effect on cardiomyocyte, and an interesting tube formation ability, decreased the heart fibrosis and infarct size, and improved the heart function.ConclusionTherapies employing MSCs with ACE2 overexpression may represent an effective treatment for improving the myocardium microenvironment and the cardiac function after MI.

scholarly journals Effects of bone marrow mesenchymal stem cells on the cardiac function and immune system of mice with endotoxemia

2016 ◽  
Vol 13 (6) ◽  
pp. 5317-5325 ◽  
Author(s):  
YUANFAN WU ◽  
JING ZHOU ◽  
LIQING BI ◽  
MIN HUANG ◽  
YI HAN ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Immune System ◽  
Cardiac Function ◽  
Marrow Mesenchymal Stem Cells

Mesenchymal stem cells enhanced cardiac function as detected by radial strain echocardiography in a doxorubicin induced cardiotoxicity

2011 ◽  
Vol 205 ◽  
pp. S58-S59
Author(s):  
M.S. Oliveira ◽  
M.B. Melo ◽  
J.L. Carvalho ◽  
R.A.S. Santos ◽  
M.M. Melo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cardiac Function ◽  
Radial Strain ◽  
Strain Echocardiography

Umbilical-cord-blood-derived mesenchymal stem cells seeded onto fibronectin-immobilized polycaprolactone nanofiber improve cardiac function

2014 ◽  
Vol 10 (7) ◽  
pp. 3007-3017 ◽  
Author(s):  
Byung-Jae Kang ◽  
Hwan Kim ◽  
Seul Ki Lee ◽  
Joohyun Kim ◽  
Yiming Shen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cardiac Function ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood
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