Astragaloside IV inhibits protein tyrosine phosphatase 1B and improves insulin resistance in insulin-resistant HepG2 cells and triglyceride accumulation in oleic acid (OA)-treated HepG2 cells

2020 ◽  
pp. 113556
Author(s):  
Xiao Zhou ◽  
Lin Lin Wang ◽  
Wen Jing Tang ◽  
Biao Tang
Keyword(s):  
Insulin Resistance ◽  
Oleic Acid ◽  
Protein Tyrosine Phosphatase ◽  
Hepg2 Cells ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Astragaloside Iv ◽  
Protein Tyrosine ◽  
Insulin Resistant ◽  
Triglyceride Accumulation

Reduced Insulin Resistance Contributes to the Beneficial Effect of Protein Tyrosine Phosphatase-1B Deletion in a Mouse Model of Sepsis

Shock ◽  
2017 ◽  
Vol 48 (3) ◽  
pp. 355-363 ◽  
Author(s):  
Eugénie Delile ◽  
Rémi Nevière ◽  
Pierre-Alain Thiébaut ◽  
Julie Maupoint ◽  
Paul Mulder ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Mouse Model ◽  
Beneficial Effect ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine

scholarly journals Endocytosis mechanism of a novel proteoglycan, extracted from Ganoderma lucidum, in HepG2 cells

RSC Advances ◽  
2017 ◽  
Vol 7 (66) ◽  
pp. 41779-41786 ◽  
Author(s):  
Zhou Yang ◽  
Fan Wu ◽  
Hongjie Yang ◽  
Ping Zhou
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Hepg2 Cells ◽  
Ganoderma Lucidum ◽  
Tyrosine Phosphatase ◽  
Hypoglycemic Effect ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Novel Protein

A novel protein tyrosine phosphatase 1B (PTP1B) inhibitor,FYGL, extracted fromGanoderma lucidum, was first reported to have an efficient hypoglycemic effect and high safetyin vivoin our previous study.

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