scholarly journals Endocytosis mechanism of a novel proteoglycan, extracted from Ganoderma lucidum, in HepG2 cells

RSC Advances ◽  
2017 ◽  
Vol 7 (66) ◽  
pp. 41779-41786 ◽  
Author(s):  
Zhou Yang ◽  
Fan Wu ◽  
Hongjie Yang ◽  
Ping Zhou
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Hepg2 Cells ◽  
Ganoderma Lucidum ◽  
Tyrosine Phosphatase ◽  
Hypoglycemic Effect ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Novel Protein

A novel protein tyrosine phosphatase 1B (PTP1B) inhibitor,FYGL, extracted fromGanoderma lucidum, was first reported to have an efficient hypoglycemic effect and high safetyin vivoin our previous study.

A novel protein tyrosine phosphatase 1B inhibitor from Tinospora sinensis

2012 ◽  
Vol 3 (3) ◽  
pp. 199 ◽  
Author(s):  
Prasoon Gupta ◽  
PraveenK Gupta ◽  
Upasana Sharma ◽  
Rakesh Maurya
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Novel Protein

scholarly journals Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice

2000 ◽  
Vol 20 (15) ◽  
pp. 5479-5489 ◽  
Author(s):  
Lori D. Klaman ◽  
Olivier Boss ◽  
Odile D. Peroni ◽  
Jason K. Kim ◽  
Jennifer L. Martino ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Energy Expenditure ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Tissue Specific ◽  
Protein Tyrosine ◽  
Ptp 1B ◽  
Deficient Mice

ABSTRACT Protein-tyrosine phosphatase 1B (PTP-1B) is a major protein-tyrosine phosphatase that has been implicated in the regulation of insulin action, as well as in other signal transduction pathways. To investigate the role of PTP-1B in vivo, we generated homozygotic PTP-1B-null mice by targeted gene disruption. PTP-1B-deficient mice have remarkably low adiposity and are protected from diet-induced obesity. Decreased adiposity is due to a marked reduction in fat cell mass without a decrease in adipocyte number. Leanness in PTP-1B-deficient mice is accompanied by increased basal metabolic rate and total energy expenditure, without marked alteration of uncoupling protein mRNA expression. In addition, insulin-stimulated whole-body glucose disposal is enhanced significantly in PTP-1B-deficient animals, as shown by hyperinsulinemic-euglycemic clamp studies. Remarkably, increased insulin sensitivity in PTP-1B-deficient mice is tissue specific, as insulin-stimulated glucose uptake is elevated in skeletal muscle, whereas adipose tissue is unaffected. Our results identify PTP-1B as a major regulator of energy balance, insulin sensitivity, and body fat stores in vivo.

Identification of Phosphocaveolin-1 as a Novel Protein Tyrosine Phosphatase 1B Substrate†

Biochemistry ◽  
2006 ◽  
Vol 45 (1) ◽  
pp. 234-240 ◽  
Author(s):  
Hyangkyu Lee ◽  
Laiping Xie ◽  
Yong Luo ◽  
Seung-Yub Lee ◽  
David S. Lawrence ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Novel Protein
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