Endometrial blood flow area is a good marker for diagnosis of pregnant mares on day 8 post-ovulation before performing the uterine lavage for embryo recovery

2020 ◽  
Vol 89 ◽  
pp. 103075
Author(s):  
P. Nieto-Olmedo ◽  
G. Gaitskell-Phillips ◽  
F.E. Martín-Cano ◽  
J.M. Ortiz-Rodríguez ◽  
F.J. Peña ◽  
...  
Keyword(s):  
Blood Flow ◽  
Flow Area ◽  
Embryo Recovery ◽  
Good Marker ◽  
Uterine Lavage ◽  
Endometrial Blood Flow

scholarly journals Long-Term Progestin-Only Contraceptives Result in Reduced Endometrial Blood Flow and Oxidative Stress

2006 ◽  
Vol 91 (9) ◽  
pp. 3633-3638 ◽  
Author(s):  
M. Hickey ◽  
G. Krikun ◽  
P. Kodaman ◽  
Frederick Schatz ◽  
C. Carati ◽  
...  
Keyword(s):  
Blood Flow ◽  
Western Australia ◽  
Access To Health Care ◽  
Abnormal Uterine Bleeding ◽  
Yale University ◽  
Discontinue Therapy ◽  
Endometrial Blood Flow

Abstract Context: Because of their safety and efficacy, long-term progestin-only contraceptives (LTPOCs) are well-suited for women with restricted access to health care. However, abnormal uterine bleeding (AUB) causes half of all users to discontinue therapy within 12 months. Endometria of LTPOC-treated patients display aberrant angiogenesis with abnormally enlarged, thin-walled, fragile blood vessels, inflammation, and focal hemorrhage. In this study, similar effects were observed with a new third-generation implantable LTPOC. Objective: We hypothesized that LTPOC reduces uterine and endometrial blood flow, leading to hypoxia/reperfusion, which triggers the generation of reactive oxygen species. The latter induce aberrant angiogenesis, causing AUB. Design: Endometrial perfusion was measured by laser-Doppler fluxmetry in women requesting LTPOCs. Endometrial biopsies were obtained for in vivo and in vitro experiments. Setting: The study was conducted in the Yale University School of Medicine and Family-Planning Center in Western Australia. Patients: Seven women 18 yr or older requesting implantable LTPOCs were recruited in Western Australia. Intervention: Women received etonorgestrel implants. Main Outcome: LTPOC treatment resulted in reduced endometrial perfusion and increased endometrial oxidative damage. Conclusions: We propose that LTPOCs result in hypoxia reperfusion, which leads to aberrant angiogenesis resulting in AUB.

scholarly journals The role of temporal changes in endometrial blood flow in natural and hormone replacement cycles with vitrified-warmed embryo transfer

2019 ◽  
Author(s):  
Kuniaki Ota ◽  
Toshifumi Takahashi ◽  
Satoru Shiraishi ◽  
Hideki Mizunuma
Keyword(s):  
Blood Flow ◽  
Embryo Transfer ◽  
Hormone Replacement ◽  
Follicular Phase ◽  
Natural Cycle ◽  
Uterine Blood Flow ◽  
Early Follicular Phase ◽  
Endometrial Blood Flow ◽  
Hcg Trigger ◽  
Natural Cycles

Abstract Background Uterine blood flow promotes endometrial development and subsequent implantation of fertilized eggs. We examined the temporal changes in uterine blood flow during natural and hormone replacement (HRT) cycles and clarified the relationship between uterine blood flow and assisted reproductive technology outcomes for vitrified-warmed embryo transfer (ET). Methods This was a retrospective cohort study. A total of 60 patients with vitrified-warmed ET were assigned to two groups according to the endometrial preparation: natural cycle (28 patients) or HRT cycle (32 patients). The uterine endometrial blood flow was evaluated using measurements of the radial artery resistance index (RA-RI) during the early follicular phase, the days of the human chorionic gonadotropin (hCG) trigger during a natural cycle or the start of progesterone administration during the HRT cycle, and the day of ET. We statistically and longitudinally measured and evaluated the RA-RI values of all individual patients. Results During natural cycles, the RA-RI on the day of ET was significantly higher than that during the early follicular phase. During HRT cycles, the RA-RI on the day of ET was also significantly increased compared to that during the early follicular phase. We validated the efficacy of the RA-RI values for predicting the possibility of pregnancy with vitrified-warmed ET. During natural cycles, the area under the receiver-operating characteristic curves (AUCs) for the early follicular phase, the day of hCG trigger, and the day of ET were 0.75 (95% confidence interval [CI], 0.57–0.93), 0.69 (95% CI, 0.49–0.88), and 0.60 (95% CI, 0.36–0.84), respectively. During HRT cycles, AUCs for the early follicular phase, the day of starting progesterone administration, and the day of ET were 0.60 (95% CI, 0.40–0.81), 0.60 (95% CI, 0.39–0.87), and 0.58 (95% CI, 0.37–0.79), respectively. Conclusions The uterine RA-RI increased at approximately the time of the implantation window compared to that of the early follicular phase during both natural and HRT cycles with vitrified-warmed ET. Our findings suggest that RA-RI during the early follicular phase might be effective and useful for deciding whether to choose the natural or HRT cycle for vitrified-warmed ET.

scholarly journals ATOSIBAN AND BARUSIBAN IMPROVED IMPAIRED ENDOMETRIAL BLOOD FLOW IN PREGNANT RABBITS

2020 ◽  
Vol 114 (3) ◽  
pp. e348
Author(s):  
Joan-Carles Arce ◽  
Luciano Cunego ◽  
Paolo Perfetti ◽  
Stéphane P. Milano ◽  
Torsten M. Reinheimer
Keyword(s):  
Blood Flow ◽  
Endometrial Blood Flow

scholarly journals The impact of botulinum toxin a (BoTA) treatment on endometrial blood flow

2019 ◽  
Vol 112 (3) ◽  
pp. e246
Author(s):  
Youn-Jung Kang ◽  
Sooyeon Kim ◽  
Siwon Lee ◽  
Hwang Kwon ◽  
Jung-Jae Ko ◽  
...  
Keyword(s):  
Blood Flow ◽  
Botulinum Toxin ◽  
Botulinum Toxin A ◽  
Toxin A ◽  
The Impact ◽  
Endometrial Blood Flow

scholarly journals Endometrial Thickness and Subendometrial Vascularity in Anovulatory Polycystic Ovarian Syndrome Patients Treated by Metformin

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
W M Khalaf ◽  
S A Akl ◽  
R R Ramadan ◽  
M A M Kamaleldin
Keyword(s):  
Insulin Resistance ◽  
Blood Flow ◽  
Uterine Artery ◽  
Endometrial Thickness ◽  
Endometrial Receptivity ◽  
Metformin Therapy ◽  
Artery Flow ◽  
Ovarian Syndrome ◽  
Endometrial Blood Flow ◽  
Endometrial Vascularity

Abstract Background PCOS, the commonest endocrinalogical disorder affecting women of age group between 18 and 44 years. PCOS compromises fertility through various pathways as hyperandrogenism, insulin resistance and impedance of the uterine and endometrial blood flow. Metformin improves the blood flow to the endometrium through reducing androgen level and correction of insulin resistance. The commonest parameters used to detect the endometrial receptivity outcome are endometrial vascular indices. Aim of the Work to evaluate the outcome of metformin administration in anovualtory PCO patients and its effect on the endometrium, including its role in ovulation and improvement of pregnancy rates. Patients and Methods this study included 85 patients from Ain Shams University outpatient gynecology and infertility clinic during the period from January 2018 till June 2018. These patients were investigated before treatment with ultrasound on day 14, 21 to evaluate the endometrial receptivity parameters such as endometrial thickness, uterine artery vascularity, endometrial and subendometrial vascularity. The patients received metformin 500mg three times per day for three months. After this duration they were reevaluated by ultrasound at days 14, 21 to detect any improvement. Results metformin therapy resulted in a significant increase of endometrial thickness and had a significant effect on uterine RI and PI. On the endometrial level, the endometrial and subendometrial R.I and P.I were significantly reduced after metformin treatment indicating better blood flow. Conclusion Metformin therapy improves endometrial vascularity, in addition to increasing endometrial thickness and improved impedance observed in uterine artery flow.

scholarly journals OC19.03: Three-dimensional vascular endometrial blood flow and “vascular cytokines”: a new approach of the uterine receptivity

2005 ◽  
Vol 26 (4) ◽  
pp. 340-340
Author(s):  
N. Lédée ◽  
R. Lombroso ◽  
S. Dubanchet ◽  
Y. Hillion ◽  
C. Meynant ◽  
...  
Keyword(s):  
Blood Flow ◽  
Three Dimensional ◽  
Uterine Receptivity ◽  
New Approach ◽  
Endometrial Blood Flow

scholarly journals Dataset of endometrial blood flow from pregnant and non-pregnant mares on day 7 and 8 post-ovulation

Data in Brief ◽  
2020 ◽  
Vol 30 ◽  
pp. 105616
Author(s):  
Pilar Nieto-Olmedo ◽  
Gemma Gaitskell-Phillips ◽  
Francisco E Martín-Cano ◽  
Jose Manuel Ortiz-Rodríguez ◽  
Fernando J Peña ◽  
...  
Keyword(s):  
Blood Flow ◽  
Endometrial Blood Flow

scholarly journals Effect of nitric oxide donors on uterine and sub-endometrial blood flow in patients with unexplained infertility: a randomized controlled trial

2021 ◽  
Vol 10 (6) ◽  
pp. 2178
Author(s):  
Mohamed A. Abdel Hafeez ◽  
Ashraf M. F. Kortam ◽  
Alaa M. A. Youssef ◽  
Ahmed Reda ◽  
Rehab M. Abdelrahman
Keyword(s):  
Blood Flow ◽  
Uterine Artery ◽  
Endometrial Thickness ◽  
Controlled Trial ◽  
Unexplained Infertility ◽  
Control Group ◽  
Artery Blood Flow ◽  
Randomized Controlled ◽  
Endometrial Blood Flow ◽  
Fertile Women

Background: Impaired sub-endometrial perfusion might reduce endometrial receptivity and possibly contribute to unexplained infertility. A favorable effect on sub-endometrial blood flow has been demonstrated with nitric oxide.Methods: This randomized controlled trial evaluated the effect of nitroglycerine on uterine and sub-endometrial blood flow in women with unexplained infertility. Sixty women were randomized into 2 equal groups. The study group received 5mg nitroglycerine patch daily from day 2 of the cycle till the evaluation day and the control group received no treatment. Independent of the study arms, 30 parous women were included as the fertile group. Six to eight days after detecting luteinizing hormone surge, women were assessed for endometrial thickness, uterine artery blood flow with color Doppler and sub-endometrial blood flow with three-dimensional power Doppler.Results: Compared to fertile women, cases with unexplained infertility (control group) had a significantly thinner endometrium, higher uterine artery Doppler indices and lower sub-endometrial blood flow. Women who received nitroglycerin showed a significant improvement in sub-endometrial blood flow while uterine artery blood flow did not show a significant difference; however, the values were also comparable to fertile women. In addition, no effect on endometrial thickness was found with nitroglycerin treatment. Nitroglycerin treatment side effects were headache, blurring of vision and hypotension. These adverse effects were not significant compared to controls.Conclusions: In women with unexplained infertility, nitroglycerin significantly improved the sub-endometrial blood flow but did not affect the endometrial thickness.

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