scholarly journals Endometrial blood flow is impaired in women with polycystic ovarian syndrome who are clinically hyperandrogenic

2009 ◽  
Vol 34 (3) ◽  
pp. 326-334 ◽  
Author(s):  
P. Lam ◽  
I. Johnson ◽  
N. Raine-Fenning
QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
W M Khalaf ◽  
S A Akl ◽  
R R Ramadan ◽  
M A M Kamaleldin

Abstract Background PCOS, the commonest endocrinalogical disorder affecting women of age group between 18 and 44 years. PCOS compromises fertility through various pathways as hyperandrogenism, insulin resistance and impedance of the uterine and endometrial blood flow. Metformin improves the blood flow to the endometrium through reducing androgen level and correction of insulin resistance. The commonest parameters used to detect the endometrial receptivity outcome are endometrial vascular indices. Aim of the Work to evaluate the outcome of metformin administration in anovualtory PCO patients and its effect on the endometrium, including its role in ovulation and improvement of pregnancy rates. Patients and Methods this study included 85 patients from Ain Shams University outpatient gynecology and infertility clinic during the period from January 2018 till June 2018. These patients were investigated before treatment with ultrasound on day 14, 21 to evaluate the endometrial receptivity parameters such as endometrial thickness, uterine artery vascularity, endometrial and subendometrial vascularity. The patients received metformin 500mg three times per day for three months. After this duration they were reevaluated by ultrasound at days 14, 21 to detect any improvement. Results metformin therapy resulted in a significant increase of endometrial thickness and had a significant effect on uterine RI and PI. On the endometrial level, the endometrial and subendometrial R.I and P.I were significantly reduced after metformin treatment indicating better blood flow. Conclusion Metformin therapy improves endometrial vascularity, in addition to increasing endometrial thickness and improved impedance observed in uterine artery flow.


Author(s):  
Jihe Zhu ◽  
Blagica Arsovska ◽  
Kristina Kozovska

Acupuncture as part of the Traditional Chinese Medicine (TCM) is used very often as a treatment option for patients struggling with infertility. Acupuncture can help in regulating the hormonal imbalances, relieve the stress and increase the blood flow to the ovaries and uterus. The treated patient is 30 year old woman diagnosed with polycystic ovarian syndrome (PCOS) and infertility. The patient was trying to get pregnant for a year and a half. The menstrual cycles were irregular and the patient was taking the medication Diane for 4 years. The hormonal analysis showed high FSH levels and low Estrogen and Progesterone. The patient has done 6 treatments in a period of two months and after the 6th treatment she got pregnant. Treatments were done in a clinic for TCM and acupuncture in Skopje, Macedonia by a doctor specialist in acupuncture. Treatments were with duration of 30-45 minutes, done once weekly on points located on the both sides of the body. The treated points are: Ex-CA1 (Zigongxue), Gv20 (Baihui), St25 (Tianshu), St36 (Zusanli), Ren12 (Zhongwan), Ren6 (Qihai), Ren2 (Qugo), Sp6 (Sanyinjiao), Li4 (Hegu), Lv3 (Taichong) and Ashi points located on front side of the neck. Acupuncture as a treatment for infertility is very effective and gives excellent results by improving the hormonal levels, the menstruation and the ovulation in women, thus giving a chance to the patients to become pregnant.


2019 ◽  
Vol 11 (1) ◽  
pp. 17-23
Author(s):  
Jinnat Ara Islam ◽  
Fatema Ashraf ◽  
Eva Rani Nandi

Background: Polycystic ovarian syndrome (PCOS) is a condition characterized by menstrual abnormalities (oligo/amenorrhea) and clinical or biochemical features of hyperandrogenism and may manifest at any age. It is a common cause of female subfertility. All the dimensions of PCOS have not been yet completely explored. Methods: It was a cross sectional comparative study carried out at-GOPD of Shaheed Suhrawardy Medical College & Hospital from January, 2016 to December 2016 on 162 subfertile women. Among them 54 were PCOS group and 108 were non PCOS group. PCOS was diagnosed by (Rotterdam criteria 2003) (i) Oligo or anovulation (ii) hyperandrogenism (iii) Polycystic ovaries. Study was done to evaluate and compare the demographic characteristics, clinical, biochemical and ultrasoundgraphic features of sub-fertile women with and without PCOS. Results: A total of 162 sub-fertile women aged 16-36 years. Mean age was 29.5±5.4. There were significant differences between the two groups in terms of (oligo/amenorrhea), hirsutism, WHR and ovarian ultrasound features. There were no significant differences between two groups in correlations between the level of obesity with the incidence of anovulation, hyperandrogenism or with hormonal features. Conclusion: PCOS is one of the important factors causing Infertility. It is an ill-defined symptom complex needed due attention. There is a need to increase awareness regarding. The clinical features of PCOS are heterogenous thus can be investigated accordingly of selection of appropriate treatment modality. J Shaheed Suhrawardy Med Coll, June 2019, Vol.11(1); 17-23


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