:
Alzheimer's disease (AD) is a chronic neurodegenerative brain disorder characterized by memory impairment,
dementia, oxidative stress in elderly people. Currently, only a few drugs are available in the market with various adverse effects. So to develop new drugs with protective action against the disease, research is turning to the identification of plant
products as a remedy. Natural compounds with anti-inflammatory activity could be good candidates for developing effective
therapeutic strategies. Phytochemicals including Curcumin, Resveratrol, Quercetin, Huperzine-A, Rosmarinic acid,
genistein, obovatol, and Oxyresvertarol were reported molecules for the treatment of AD. Several alkaloids such as galantamine, oridonin, glaucocalyxin B, tetrandrine, berberine, anatabine have been shown anti-inflammatory effects in AD models in vitro as well as in-vivo. In conclusion, natural products from plants represent interesting candidates for the treatment
of AD. This review highlights the potential of specific compounds from natural products along with their synthetic derivatives to counteract AD in the CNS.
In vitro and In vivo Assessment of Pi3Kγ Inhibitors for Anti-Inflammatory Indications: Challenges of Selectivity over Pi3Kα
