Faculty Opinions recommendation of Annexin 1 induced by anti-inflammatory drugs binds to NF-kappaB and inhibits its activation: anticancer effects in vitro and in vivo.

It has been demonstrated that some non-steroidal anti-inflammatory drugs (NSAIDs), like acetylsalicylic acid, diclofenac, and ibuprofen, have anti-biofilm activity in concentrations found in human pharmacokinetic studies, which could fuel an interest in repurposing these well tolerated drugs as adjunctive therapies for biofilm-related infections. Here we sought to review the currently available data on the anti-biofilm activity of NSAIDs and its relevance in a clinical context. We performed a systematic literature review to identify the most commonly tested NSAIDs drugs in the last 5 years, the bacterial species that have demonstrated to be responsive to their actions, and the emergence of resistance to these molecules. We found that most studies investigating NSAIDs’ activity against biofilms were in vitro, and frequently tested non-clinical bacterial isolates, which may not adequately represent the bacterial populations that cause clinically-relevant biofilm-related infections. Furthermore, studies concerning NSAIDs and antibiotic resistance are scarce, with divergent outcomes. Although the potential to use NSAIDs to control biofilm-related infections seems to be an exciting avenue, there is a paucity of studies that tested these drugs using appropriate in vivo models of biofilm infections or in controlled human clinical trials to support their repurposing as anti-biofilm agents.

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A REVIEW ON IN VIVO AND IN VITRO EXPERIMENTAL MODELS TO INVESTIGATE THE ANTI-INFLAMMATORY ACTIVITY OF HERBAL EXTRACTS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i11.26873 ◽

2018 ◽

Vol 11 (11) ◽

pp. 29

Author(s):

Inayat Kabir ◽

Imtiyaz Ansari

Keyword(s):

Reference Model ◽

Experimental Models ◽

Inflammatory Activity ◽

Herbal Extracts ◽

Double Positive ◽

Arthritis Models ◽

Inflammatory Drugs ◽

Anti Inflammatory

The article emphasizes the anti-inflammatory effects of herbal extracts on different experimental models that are repeatedly used to test the in vivo anti-inflammatory activity of herbal components. Edema, granuloma and arthritis models are used to test the anti-inflammatory activity of plant extracts whereas formalin or acetic acid-induced writhing test and hot plate methods are the most repeatedly used to evaluate anti-nociceptive potentials of the herbal extracts. Although adjuvant-induced and collagen-induced arthritis models are also quite efficient, they have been used seldom to evaluate anti-inflammatory tendencies of the herbs. Here, we suggest a double positive reference model using both steroid and nonsteroidal anti-inflammatory drugs at the same time, instead of using only one of them either.

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Comparison of the nephroprotective effects of non-steroidal anti-inflammatory drugs on cisplatin-induced nephrotoxicity in vitro and in vivo

European Journal of Pharmacology ◽

10.1016/j.ejphar.2020.173339 ◽

2020 ◽

Vol 884 ◽

pp. 173339

Author(s):

Keisuke Okamoto ◽

Yoshitaka Saito ◽

Katsuya Narumi ◽

Ayako Furugen ◽

Ken Iseki ◽

...

Keyword(s):

Inflammatory Drugs ◽

Anti Inflammatory

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Biodegradation of poly(anhydride-esters) into non-steroidal anti-inflammatory drugs and their effect on Pseudomonas aeruginosa biofilms in vitro and on the foreign-body response in vivo

Biomaterials ◽

10.1016/j.biomaterials.2006.05.034 ◽

2006 ◽

Vol 27 (29) ◽

pp. 5039-5048 ◽

Cited By ~ 49

Author(s):

James D. Bryers ◽

Rebecca A. Jarvis ◽

Jason Lebo ◽

Almudena Prudencio ◽

Themis R. Kyriakides ◽

...

Keyword(s):

Pseudomonas Aeruginosa ◽

Foreign Body ◽

Foreign Body Response ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Body Response

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Inhibitory Effect of Herbal Remedy PERVIVO and Anti-Inflammatory Drug Sulindac on L-1 Sarcoma Tumor Growth and Tumor Angiogenesis in Balb/c Mice

Mediators of Inflammation ◽

10.1155/2013/289789 ◽

2013 ◽

Vol 2013 ◽

pp. 1-10 ◽

Cited By ~ 3

Author(s):

P. Skopiński ◽

B. J. Bałan ◽

J. Kocik ◽

R. Zdanowski ◽

S. Lewicki ◽

...

Keyword(s):

Tumor Growth ◽

Tumor Angiogenesis ◽

Herbal Remedy ◽

Inhibitory Effect ◽

Inflammatory Drug ◽

Anticancer Effects ◽

Biologic Response ◽

Inflammatory Drugs ◽

Anti Inflammatory

Anticancer activity of many herbs was observed for hundreds of years. They act as modifiers of biologic response, and their effectiveness may be increased by combining multiple herbal extracts . PERVIVO, traditional digestive herbal remedy, contains some of them, and we previously described its antiangiogenic activity. Numerous studies documented anticancer effects of nonsteroidal anti-inflammatory drugs. We were the first to show that sulindac and its metabolites inhibit angiogenesis. In the present paper the combinedin vivoeffect of multicomponent herbal remedy PERVIVO and nonsteroidal anti-inflammatory drug sulindac on tumor growth, tumor angiogenesis, and tumor volume in Balb/c mice was studied. These effects were checked after grafting cells collected from syngeneic sarcoma L-1 tumors into mice skin. The strongest inhibitory effect was observed in experimental groups treated with PERVIVO and sulindac together. The results of our investigation showed that combined effect of examined drugs may be the best way to get the strongest antiangiogenic and antitumor effect.

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Synthesis of new ibuprofen hybrid conjugates as potential anti-inflammatory and analgesic agents

Future Medicinal Chemistry ◽

10.4155/fmc-2020-0109 ◽

2020 ◽

Vol 12 (15) ◽

pp. 1369-1386

Author(s):

Siva S Panda ◽

Adel S Girgis ◽

Hitesh H Honkanadavar ◽

Riham F George ◽

Aladdin M Srour

Keyword(s):

Writhing Test ◽

Rat Paw Edema ◽

Analgesic Agents ◽

Inflammatory Drugs ◽

Cox 2 ◽

Anti Inflammatory ◽

Rat Paw ◽

Inhibition Studies

Background: A new set of hybrid conjugates derived from 2-(4-isobutylphenyl)propanoic acid (ibuprofen) is synthesized to overcome the drawbacks of the current non-steroidal anti-inflammatory drugs. Results & methodology: Synthesized conjugates were screened for their anti-inflammatory, analgesic and ulcerogenic properties. Few conjugates were found to have significant anti-inflammatory properties in the carrageenan-induced rat paw edema test, while a fair number of conjugates showed promising peripheral analgesic activity in the acetic acid-induced writhing test as well as central analgesic properties in the in vivo hot plate technique. The newly synthesized conjugates did not display any ulcerogenic liability. Conclusion: In vitro, COX-1 and COX-2 enzyme inhibition studies raveled compound 7e is more selective toward COX-2 compared with ibuprofen.

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The drug likeness analysis of anti-inflammatory clerodane diterpenoids

Chinese Medicine ◽

10.1186/s13020-020-00407-w ◽

2020 ◽

Vol 15 (1) ◽

Author(s):

Zheling Feng ◽

Jun Cao ◽

Qingwen Zhang ◽

Ligen Lin

Keyword(s):

Marine Sponges ◽

The Body ◽

Low Grade ◽

Active Defense ◽

Inflammatory Drugs ◽

Clerodane Diterpenoids ◽

Anti Inflammatory ◽

External Stimuli

AbstractInflammation is an active defense response of the body against external stimuli. Long term low-grade inflammation has been considered as a deteriorated factor for aging, cancer, neurodegeneration and metabolic disorders. The clinically used glucocorticoids and non-steroidal anti-inflammatory drugs are not suitable for chronic inflammation. Therefore, it’s urgent to discover and develop new effective and safe drugs to attenuate inflammation. Clerodane diterpenoids, a class of bicyclic diterpenoids, are widely distributed in plants of the Labiatae, Euphorbiaceae and Verbenaceae families, as well as fungi, bacteria, and marine sponges. Dozens of anti-inflammatory clerodane diterpenoids have been identified on different assays, both in vitro and in vivo. In the current review, the up-to-date research progresses of anti-inflammatory clerodane diterpenoids were summarized, and their druglikeness was analyzed, which provided the possibility for further development of anti-inflammatory drugs.

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