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NiO nanoparticles are utilized to effectively strengthen annulated pyrano [2, 3- d] pyrimidine synthesis through primary Knoevenagel, following Micheal and ultimate heterocyclization reactions of aldehyde, malononitrile, and barbituric acid. The characteristics of NiO nanoparticles are identified using advanced techniques, such as IR, UV, EDX, XRD, SEM, and TEM. The nano-NiO particles are mostly below < 100 nm in size with uniform spherical shapes. The adopted approach is advantages thanks to its simple processing, relatively short reaction time, often good to high average yields, convenient workability, and environmental friendliness.
A convenient two-step, one-pot synthesis of 4-chloro-2-(trichloromethyl)pyrimidines starting from 2-(trichloromethyl)-1,3-diazabutadienes is described. These nitrogen heterocycles were prepared by a sequential acylation/intramolecular cyclization reaction between 2-(trichloromethyl)-1,3-diazabutadienes and acyl chlorides in the presence of triethylamine followed by treatment with POCl3. This is the first report for the synthesis of this type of 4-chloro-2-(trichloromethyl)pyrimidine derivatives and serves as a source for a wide variety of other substituted pyrimidines by nucleophilic substitution reactions.
A novel series of dihydropyrido[2,3-d]pyrimidine derivatives were synthesized by multicomponent
domino cyclization via the one-pot three component reaction of 6-amino uracil, substituted aryl
aldehydes and N-methyl-1-(methylthio)-2-nitroethenamine in the presence of PTSA 10 mol% as a
catalyst. The structures of these synthesized compounds were characterized by spectral analysis. Further
the synthesized compounds screened for in vitro antimicrobial activity. Among all the compounds,
compound 4b containing flouro substitution exhibited good inhibition against the tested species.
NiO nanoparticles: A highly efficient catalyst for the one-pot three-component synthesis of pyrano [2, 3-d] pyrimidine derivatives in green media.