Molecular classification of hepatocellular adenoma in clinical practice

2017 ◽  
Vol 67 (5) ◽  
pp. 1074-1083 ◽  
Author(s):  
Jean-Charles Nault ◽  
Valérie Paradis ◽  
Daniel Cherqui ◽  
Valérie Vilgrain ◽  
Jessica Zucman-Rossi
Keyword(s):  
Clinical Practice ◽  
Hepatocellular Adenoma ◽  
Molecular Classification

scholarly journals Molecular classification of hepatocellular adenoma: A single-center experience

2019 ◽  
Vol 23 (2) ◽  
pp. 109
Author(s):  
Xue-Yin Shen ◽  
Xu-Guang Hu ◽  
Young-Bae Kim ◽  
Mi-Na Kim ◽  
Sung-Yeon Hong ◽  
...  
Keyword(s):  
Hepatocellular Adenoma ◽  
Molecular Classification ◽  
Single Center ◽  
Single Center Experience

scholarly journals Molecular Classification of Renal Cell Carcinoma and Its Implication in Future Clinical Practice

Kidney Cancer ◽  
2017 ◽  
Vol 1 (1) ◽  
pp. 3-13 ◽  
Author(s):  
Jozefina Casuscelli ◽  
Yann-Alexandre Vano ◽  
Wolf Herve Fridman ◽  
James J. Hsieh
Keyword(s):  
Renal Cell Carcinoma ◽  
Clinical Practice ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Molecular Classification ◽  
Future Clinical Practice

scholarly journals Molecular Pathology of Hepatic Neoplasms: Classification and Clinical Significance

2011 ◽  
Vol 2011 ◽  
pp. 1-15 ◽  
Author(s):  
Zenta Walther ◽  
Dhanpat Jain
Keyword(s):  
Liver Cancer ◽  
Current Knowledge ◽  
Hepatocellular Adenoma ◽  
Molecular Classification ◽  
Mutational Spectra ◽  
Hepatic Neoplasms ◽  
Technological Advances ◽  
Early Hcc ◽  
Gene Expression Studies

Recent technological advances have enabled investigators to characterize the molecular genetics and genomics of hepatic neoplasia in remarkable detail. From these studies, an increasing number of molecular markers are being identified that correlate with clinically important tumor phenotypes. This paper discusses current knowledge relevant to the molecular classification of epithelial primary hepatic tumors that arise in adults, including focal nodular hyperplasia (FNH), hepatocellular adenoma (HCA), hepatocellular carcinoma (HCC), cholangiocarcinoma (CC), and combined HCC-CC. Genetic analysis has defined molecular subtypes of HCA that are clinicopathologically distinct and can be distinguished through immunohistochemistry. Gene expression studies have identified molecular signatures of progression from dysplastic nodules (DNs) to early HCC in cirrhosis. Analyses of the mutational spectra, chromosomal aberrations and instability, transcriptomics, and microRNA profiles of HCC have revealed the existence of biologically distinct subtypes of this common malignancy, with prognostic implications. Molecular characterization of biliary and hepatic progenitor cell phenotypes in liver cancer has shed new light on the histogenesis of these tumors and has focused attention on novel therapeutic targets. In coming years, the molecular classification of hepatic neoplasms will be increasingly valuable for guiding patient care, as targeted therapies for liver cancer are developed and brought into clinical practice.

scholarly journals Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation

2017 ◽  
Vol 152 (4) ◽  
pp. 880-894.e6 ◽  
Author(s):  
Jean-Charles Nault ◽  
Gabrielle Couchy ◽  
Charles Balabaud ◽  
Guillaume Morcrette ◽  
Stefano Caruso ◽  
...  
Keyword(s):  
Risk Factors ◽  
Malignant Transformation ◽  
Hepatocellular Adenoma ◽  
Molecular Classification

scholarly journals Molecular classification of hepatocellular adenomas: impact on clinical practice

2018 ◽  
Vol 5 (1) ◽  
pp. HEP04 ◽  
Author(s):  
Anne-Laure Védie ◽  
Olivier Sutter ◽  
Marianne Ziol ◽  
Jean-Charles Nault
Keyword(s):  
Clinical Practice ◽  
Molecular Classification ◽  
Hepatocellular Adenomas

Molecular classification of pituitary adenomas

2015 ◽  
Author(s):  
Antonio Pico ◽  
Laura Sanchez-Tejada ◽  
Ruth Sanchez-Ortiga ◽  
Rosa Camara ◽  
Cristina Lamas ◽  
...  
Keyword(s):  
Pituitary Adenomas ◽  
Molecular Classification
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