Serum adenosine deaminase enzyme and plasma platelet factor 4 activities in active pulmonary tuberculosis, HIV-seropositive subjects and cancer patients

Abstract Background Active pulmonary tuberculosis (TB) occasionally coexists with lung cancer. However, the clinical and radiologic characteristics of this cooccurrence have not been fully evaluated. Methods Patients diagnosed with lung cancer and active pulmonary TB from January 2009 to December 2017 in four hospitals of the Catholic University of Korea were retrospectively reviewed. The clinical characteristics, including the TB diagnosis methods, lung cancer pathology, staging, initial radiographic features, and survival were analyzed and compared to 575 lung cancer patients without active pulmonary TB from the same hospitals. Results Forty-eight (0.48%) of the 9,936 lung cancer patients had active pulmonary TB confirmed by positive culture results or polymerase chain reaction analysis for M. tuberculosis at the time of the initial cancer diagnosis. The majority of the patients (95.9%) had non-small cell lung cancer and 56.2% of the lung cancers were located in the both upper lobes. In the initial computed tomography, the most frequent findings were a mass-like lesion (79.2%) and separate nodules (75%). When compared to lung cancer patients without TB, the body mass index (BMI) was lower (21.4 vs. 23.1, P = 0.001) in patients with TB. Moreover, the lung cancer patients with TB had advanced clinical stages compared to patients without TB; T3-4 (70.9% vs. 50.6%, P = 0.002), N2-3 (85.2% vs. 55.6%, P < 0.001); M1 (65.9% vs. 44.5%, P = 0.007). Patients' age, histology, location, and the presence of epidermal growth factor receptor mutations were not statistically different between the two groups. Interestingly, lung cancer with TB was associated with lower mortality (hazard ratio = 0.35, 95% CI: 0.2 1– 0.60). Conclusions Rarely diagnosed concurrent active tuberculosis in lung cancer patients was associated with lower BMI and advanced clinical stages. Active investigation of and treatment for active pulmonary TB in lung cancer patients could improve patient outcomes.

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Coexistence of lung squamous cell carcinoma and pulmonary tuberculosis within a single lesion: a case report

10.21203/rs.3.rs-17664/v1 ◽

2020 ◽

Author(s):

Guoliang Xiao ◽

Shengjie Chen

Keyword(s):

Lung Cancer ◽

Squamous Cell Carcinoma ◽

Pulmonary Tuberculosis ◽

Cell Carcinoma ◽

Cancer Patients ◽

Squamous Cell ◽

Left Lung ◽

Lung Squamous Cell Carcinoma ◽

Active Pulmonary Tuberculosis ◽

Lung Cancer Patients

Abstract Background: Tuberculosis and lung cancer are common high-mortality lung diseases, but it is rare that lung cancer and tuberculosis exist in the same lesion. In addition, lung cancer with pulmonary tuberculosis is similar in morphology to lung cancer without tuberculosis. For these reasons, lung cancer patients with tuberculosis are often misdiagnosed and mistreated, so these patients have a poorer prognosis than lung cancer patients without tuberculosis. Therefore, a full understanding of such cases can help early diagnosis, so that appropriate treatments can be performed timely. Case presentations: A 52-year-old male. The physical examination revealed a cavity-like nodule in the upper left lung and the first diagnosis was tuberculosis. There was no significant change in lung nodules after anti-tuberculosis treatment. So the patient was admitted to the hospital for surgical treatment of lung cancer. Postoperative pathological showed that the lesion was lung squamous cell carcinoma with tuberculosis.Conclusion: the survival rate of patients with active pulmonary tuberculosis and lung cancer is lower than those with lung cancer or tuberculosis alone. Which is mainly due to incomplete diagnosis. if we find hollow shadows in the lungs on CT, we should think about the possibility of coexistence of lung cancer and tuberculosis, and then the appropriate treatment and management strategies should be developed.

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