Biological evaluation of bismuth non-steroidal anti-inflammatory drugs (BiNSAIDs): Stability, toxicity and uptake in HCT-8 colon cancer cells

2014 ◽  
Vol 135 ◽  
pp. 28-39 ◽  
Author(s):  
Emma L. Hawksworth ◽  
Philip C. Andrews ◽  
Wilford Lie ◽  
Barry Lai ◽  
Carolyn T. Dillon
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Biological Evaluation ◽  
Colon Cancer Cells ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Induction of apoptosis in colon cancer cells by nonsteroidal anti-inflammatory drugs

1998 ◽  
Vol 39 (4) ◽  
pp. 287 ◽  
Author(s):  
Sung Pyo Hong ◽  
Sung Ho Ha ◽  
In Suh Park ◽  
Won Ho Kim
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
Inflammatory Drugs ◽  
Induction Of Apoptosis ◽  
Anti Inflammatory

Role of caspase-3 in apoptosis of colon cancer cells induced by nonsteroidal anti-inflammatory drugs

2000 ◽  
Vol 15 (2) ◽  
pp. 105-111 ◽  
Author(s):  
W. H. Kim ◽  
Marie Yeo ◽  
Myung Soo Kim ◽  
Sang Bae Chun ◽  
Eiu Cheol Shin ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Caspase 3 ◽  
Colon Cancer Cells ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Mitochondria sustain store-operated currents in colon cancer cells but not in normal colonic cells: reversal by non-steroidal anti-inflammatory drugs

Oncotarget ◽  
2017 ◽  
Vol 8 (33) ◽  
pp. 55332-55352 ◽  
Author(s):  
Miriam Hernández-Morales ◽  
Diego Sobradillo ◽  
Ruth A. Valero ◽  
Eva Muñoz ◽  
Daniel Ubierna ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Colonic Cells

Anti-Inflammatory Effect of Buckwheat Sprouts in Lipopolysaccharide-Activated Human Colon Cancer Cells and Mice

2008 ◽  
Vol 72 (12) ◽  
pp. 3148-3157 ◽  
Author(s):  
Satoshi ISHII ◽  
Takafumi KATSUMURA ◽  
Chikara SHIOZUKA ◽  
Keisuke OOYAUCHI ◽  
Kunito KAWASAKI ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Anti Inflammatory ◽  
Human Colon Cancer Cells ◽  
Inflammatory Effect

scholarly journals AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells

PPAR Research ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-16 ◽  
Author(s):  
Angelo Cerbone ◽  
Cristina Toaldo ◽  
Stefania Pizzimenti ◽  
Piergiorgio Pettazzoni ◽  
Chiara Dianzani ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colon Cancer ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Combined Treatment ◽  
Colon Cancer Cells ◽  
Positive Interaction ◽  
Anti Inflammatory

PPARαs are nuclear receptors highly expressed in colon cells. They can be activated by the fibrates (clofibrate, ciprofibrate etc.) used to treat hyperlipidemia. Since PPARαtranscriptional activity can be negatively regulated by JNK, the inhibition of JNK activity could increase the effectiveness of PPARαligands. We analysed the effects of AS601245 (a JNK inhibitor) and clofibrate alone or in association, on proliferation, apoptosis, differentiation and the gene expression profile of CaCo-2 human colon cancer cells. Proliferation was inhibited in a dose-dependent way by clofibrate and AS601245. Combined treatment synergistically reduced cell proliferation, cyclin D1 and PCNA expression and induced apoptosis and differentiation. Reduction of cell proliferation, accompanied by the modulation of p21 expression was observed in HepG2 cells, also. Gene expression analysis revealed that some genes were highly modulated by the combined treatment and 28 genes containing PPRE were up-regulated, while clofibrate alone was ineffective. Moreover, STAT3 signalling was strongly reduced by combined treatment. After combined treatment, the binding of PPARαto PPRE increased and paralleled with the expression of the PPAR coactivator MED1. Results demonstrate that combined treatment increases the effectiveness of both compounds and suggest a positive interaction between PPARαligands and anti-inflammatory agents in humans.

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