Specificity and redundancy in the olfactory system of the bark beetle Ips typographus: Single-cell responses to ecologically relevant odors

Olfactory responses to single odors have been well characterized but in reality we are continually presented with complex mixtures of odors. We performed high-throughput analysis of single-cell responses to odor blends using Swept Confocally Aligned Planar Excitation (SCAPE) microscopy of intact mouse olfactory epithelium, imaging ~10,000 olfactory sensory neurons in parallel. In large numbers of responding cells, mixtures of odors did not elicit a simple sum of the responses to individual components of the blend. Instead, many neurons exhibited either antagonism or enhancement of their response in the presence of another odor. All eight odors tested acted as both agonists and antagonists at different receptors. We propose that this peripheral modulation of responses increases the capacity of the olfactory system to distinguish complex odor mixtures.

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Contrast modulated steady-state visual evoked potentials (CMSS VEPs): recording evoked potentials and related single cell responses in area 17 of the cat

Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section ◽

10.1016/0168-5597(94)90008-6 ◽

1994 ◽

Vol 92 (1) ◽

pp. 64-77 ◽

Cited By ~ 1

Author(s):

W. Spileers ◽

H. Maes ◽

L. Lagae ◽

G.A. Orban

Keyword(s):

Steady State ◽

Evoked Potentials ◽

Single Cell ◽

Visual Evoked Potentials ◽

Area 17 ◽

Cell Responses ◽

Single Cell Responses ◽

Visual Evoked

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Design and fabrication of high-throughput application-specific microfluidic devices for studying single-cell responses to extracellular perturbations

10.1117/12.2017301 ◽

2013 ◽

Cited By ~ 1

Author(s):

Amin A. Banaeiyan ◽

Doryaneh Ahmadpour ◽

Caroline B. Adiels ◽

Mattias Goksör

Keyword(s):

Single Cell ◽

High Throughput ◽

Microfluidic Devices ◽

Cell Responses ◽

Single Cell Responses ◽

Application Specific

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Single Cell Responses in Normal and Ototoxic Drug-Treated Gerbils

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348948008900217 ◽

1980 ◽

Vol 89 (2) ◽

pp. 176-179 ◽

Cited By ~ 1

Author(s):

Nathan B. Gross ◽

Wladimiro S. Lifschitz

Keyword(s):

Single Cell ◽

Discharge Rate ◽

Space Perception ◽

High Threshold ◽

Auditory Space ◽

Cell Responses ◽

Single Cell Responses ◽

Cell Data ◽

Ototoxic Drug ◽

Phase Differences

Single cell data were obtained from the inferior colliculus of normal gerbils and from those treated with ethacrynic acid. Response changes found for the drug-treated animals are as follows: Fewer cells responded to auditory stimulation. Recruitment-like functions were found which were characterized by high threshold and precipitous increase in discharge rate with intensity. Some units showed abnormally low discharge rate over an extended intensity range, which could be the underlying change in responsiveness in human patients with reduced loudness range. One half as many collicular units were responsive to auditory phase differences. The most severely affected ears showed abnormal dependency upon phase relations. This would affect auditory space perception.

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