scholarly journals Targeted gene delivery in the cricket brain, using in vivo electroporation

2013 ◽  
Vol 59 (12) ◽  
pp. 1235-1241 ◽  
Author(s):  
Chihiro Sato Matsumoto ◽  
Hisashi Shidara ◽  
Koji Matsuda ◽  
Taro Nakamura ◽  
Taro Mito ◽  
...  
Keyword(s):  
Gene Delivery ◽  
In Vivo Electroporation ◽  
Targeted Gene Delivery ◽  
Cricket Brain

In vivo electroporation of the central nervous system: A non-viral approach for targeted gene delivery

2010 ◽  
Vol 92 (3) ◽  
pp. 227-244 ◽  
Author(s):  
Jochen De Vry ◽  
Pilar Martínez-Martínez ◽  
Mario Losen ◽  
Yasin Temel ◽  
Thomas Steckler ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gene Delivery ◽  
In Vivo Electroporation ◽  
Targeted Gene Delivery ◽  
System A ◽  
The Central Nervous System

scholarly journals Phase I/II and Phase II Studies of Targeted Gene Delivery In Vivo: Intravenous Rexin-G for Chemotherapy-resistant Sarcoma and Osteosarcoma

2009 ◽  
Vol 17 (9) ◽  
pp. 1651-1657 ◽  
Author(s):  
Sant P Chawla ◽  
Victoria S Chua ◽  
Lita Fernandez ◽  
Doris Quon ◽  
Andreh Saralou ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Phase I ◽  
Phase Ii ◽  
Targeted Gene Delivery ◽  
Phase Ii Studies

Efficacy of In Vivo Electroporation-Mediated IL-10 Gene Delivery on Survival of Skin Flaps

2017 ◽  
Vol 251 (2) ◽  
pp. 211-219 ◽  
Author(s):  
S. Morteza Seyed Jafari ◽  
Maziar Shafighi ◽  
Helmut Beltraminelli ◽  
Benedikt Weber ◽  
Ralph. A. Schmid ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Skin Flaps ◽  
In Vivo Electroporation

scholarly journals A supramolecular platform for controlling and optimizing molecular architectures of siRNA targeted delivery vehicles

2020 ◽  
Vol 6 (31) ◽  
pp. eabc2148
Author(s):  
Yuting Wen ◽  
Hongzhen Bai ◽  
Jingling Zhu ◽  
Xia Song ◽  
Guping Tang ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Targeted Delivery ◽  
Tumor Therapy ◽  
Sirna Delivery ◽  
Targeted Gene Delivery ◽  
Delivery Vehicles ◽  
Molecular Architectures ◽  
Host Polymer

It requires multistep synthesis and conjugation processes to incorporate multifunctionalities into a polyplex gene vehicle to overcome numerous hurdles during gene delivery. Here, we describe a supramolecular platform to precisely control, screen, and optimize molecular architectures of siRNA targeted delivery vehicles, which is based on rationally designed host-guest complexation between a β-cyclodextrin–based cationic host polymer and a library of guest polymers with various PEG shape and size, and various density of ligands. The host polymer is responsible to load/unload siRNA, while the guest polymer is responsible to shield the vehicles from nonspecific cellular uptake, to prolong their circulation time, and to target tumor cells. A series of precisely controlled molecular architectures through a simple assembly process allow for a rapid optimization of siRNA delivery vehicles in vitro and in vivo for therapeutic siRNA-Bcl2 delivery and tumor therapy, indicating the platform is a powerful screening tool for targeted gene delivery vehicles.

Receptor-Mediated Gene Delivery Using Chitosan Derivatives In Vitro and In Vivo

2007 ◽  
Vol 342-343 ◽  
pp. 449-452 ◽  
Author(s):  
Tae Hee Kim ◽  
Hua Jin ◽  
Hyun Woo Kim ◽  
Myung Haing Cho ◽  
Jae Woon Nah ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Transfection Efficiency ◽  
Viral Gene ◽  
Gene Delivery System ◽  
Targeted Gene Delivery ◽  
Cell Specificity ◽  
Selective Delivery

The key strategy for the advancement of gene therapy is the development of an efficient targeted gene delivery system into cells. The targeted gene delivery system is especially important in non-viral gene transfer which shows the relatively low transfection efficiency. It also opens the possibility of selective delivery of therapeutic plasmids to specific tissues. Chitosan has been considered to be a good candidate for gene delivery system, since it is already known as a biocompatible, biodegradable, and low toxic material with high cationic potential. However, low specificity and low transfection efficiency of chitosan need to be overcome prior to clinical trial. In this study, we focused on the chemical modification of chitosan for enhancement of cell specificity and transfection efficiency. Also, the potential of clinical application was investigated.

Efficient gene delivery into murine ovarian cells by intraovarian injection of plasmid DNA and subsequent in vivo electroporation

genesis ◽  
2003 ◽  
Vol 35 (3) ◽  
pp. 169-174 ◽  
Author(s):  
Masahiro Sato ◽  
Maya Tanigawa ◽  
Natsuko Kikuchi ◽  
Shingo Nakamura ◽  
Minoru Kimura
Keyword(s):  
Gene Delivery ◽  
Plasmid Dna ◽  
In Vivo Electroporation ◽  
Ovarian Cells ◽  
Efficient Gene

scholarly journals Targeted Gene Delivery to Vascular Tissue In Vivo by Tropism-Modified Adeno-Associated Virus Vectors

Circulation ◽  
2004 ◽  
Vol 109 (4) ◽  
pp. 513-519 ◽  
Author(s):  
Stephen J. White ◽  
Stuart A. Nicklin ◽  
Hildegard Büning ◽  
M. Julia Brosnan ◽  
Kristen Leike ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Vascular Tissue ◽  
Adeno Associated Virus ◽  
Virus Vectors ◽  
Targeted Gene Delivery

Pancreatic Cancer Induced by In Vivo Electroporation-Enhanced Sleeping Beauty Transposon Gene Delivery System in Mouse

Pancreas ◽  
2014 ◽  
Vol 43 (4) ◽  
pp. 614-618 ◽  
Author(s):  
June-Shine Park ◽  
Kyung-Min Lim ◽  
Sung Goo Park ◽  
Sun Young Jung ◽  
Hyun-Ji Choi ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Gene Delivery ◽  
Delivery System ◽  
Sleeping Beauty ◽  
Gene Delivery System ◽  
In Vivo Electroporation ◽  
Sleeping Beauty Transposon
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