scholarly journals How does stent expansion alter drug transport properties of the arterial wall?

Author(s):  
Javier Escuer ◽  
Martina Cebollero ◽  
Estefanía Peña ◽  
Sean McGinty ◽  
Miguel A. Martínez
Author(s):  
Alireza Karimi ◽  
Reza Razaghi ◽  
Ahmad Shojaei ◽  
Mahdi Navidbakhsh

AbstractThe stresses induced within plaque tissues and arterial layers during stent expansion inside an atherosclerotic artery can be exceeded from the yield stresses of those tissues and, consequently, lead to plaque or arterial wall rupture. The distribution and magnitude of the stresses in the plaque-artery-stent structure might be distinctly different for different plaque types. In this study, the mechanical properties of six healthy and atherosclerotic human coronary arteries were determined for application in plaque and arterial vulnerability assessment. A nonlinear finite element simulation based on an Ogden material model was established to investigate the effect of plaque types on the stresses induced in the arterial wall during implantation of a balloon expandable coronary stent. The atherosclerotic artery was assumed to consist of a plaque and normal arterial tissues on its outer side. The results indicated a significant influence of plaque types on the maximum stresses induced within the plaque wall and arterial wall during stenting but not when computing maximum stress on the stent. The stress on the stiffest calcified plaque wall was 3.161 MPa, whereas cellular and hypocellular plaques showed relatively less stress on their wall. The highest von Mises stresses within the arterial wall were observed on the hypocellular plaque, whereas the lowest stresses were seen to be located in the calcified and cellular plaques. Although the computed stresses on the arterial wall for the calcified and cellular plaques were not high enough to invoke a rupture, the stress on the hypocellular plaque was relatively higher than that of the strength of the arterial wall. These findings may have implications not only for understanding the stresses induced in plaque and the arterial wall, but also for developing surgeries such as balloon-angioplasty and stenting.


Author(s):  
Javier Escuer Gracia ◽  
Estefanía Peña Baquedano ◽  
Sean McGinty ◽  
Miguel Ángel Martínez

A computational model of the transport of drugs eluted from a drug-eluting stent (DES) in the arterial wall is developed to study the influence of considering a non-linear model of dissolution-diffusion in the polymeric strut coating of the stent and a non-linear saturable reversible reaction model in the tissue to describe drug specific and non-specific binding.


Soft Matter ◽  
2020 ◽  
Vol 16 (47) ◽  
pp. 10591-10610
Author(s):  
Ankush Singhal ◽  
John D. Schneible ◽  
Radina L. Lilova ◽  
Carol K. Hall ◽  
Stefano Menegatti ◽  
...  

Hydrogels constructed with functionalized polysaccharides are of interest in a multitude of applications, especially in the design of therapeutic and regenerative formulations. Computational models can efficiently guide their design.


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