Usefulness of 18FDG-PET/CT and MRI in an immunocompetent patient with fever of unknown origin and following diagnosis of skeletal tuberculosis

2021 ◽  
Author(s):  
Mariadea Lavalle ◽  
Gianfranco Belmonte ◽  
Federico Pallavicini ◽  
Riccardo Manfredi ◽  
Laura Maria Minordi
Keyword(s):  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Immunocompetent Patient ◽  
Skeletal Tuberculosis ◽  
18Fdg Pet ◽  
Pet Ct ◽  
Ct And Mri

Usefulness of 18FDG PET-CT scan as a diagnostic tool of fever of unknown origin

2015 ◽  
Vol 145 (2) ◽  
pp. 62-66
Author(s):  
Francisco Javier García-Gómez ◽  
Irene Acevedo-Báñez ◽  
Rubén Martínez-Castillo ◽  
Manuel García-Gutiérrez ◽  
Juan Luis Tirado-Hospital ◽  
...  
Keyword(s):  
Ct Scan ◽  
Diagnostic Tool ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
18Fdg Pet ◽  
Pet Ct ◽  
Pet Ct Scan

scholarly journals The Utility of 18FDG-PET/CT in Diagnosing Fever of Unknown Origin: The Experience of a Large Tertiary Medical Center

2021 ◽  
Vol 18 (10) ◽  
pp. 5360
Author(s):  
Hussein Mahajna ◽  
Keren Vaknin ◽  
Jennifer Ben Shimol ◽  
Abdulla Watad ◽  
Arsalan Abu-Much ◽  
...  
Keyword(s):  
Weight Loss ◽  
Predictive Value ◽  
Fever Of Unknown Origin ◽  
Diagnostic Yield ◽  
Medical Center ◽  
False Negative ◽  
Unknown Origin ◽  
18Fdg Pet ◽  
Pet Ct ◽  
Work Up

Fever of unknown origin (FUO) poses a diagnostic challenge, and 18-fluorodexoyglucose positron emission tomography with computed tomography (18FDG-PET/CT) may identify the source. We aimed to evaluate the diagnostic yield of 18FDG-PET/CT in the work-up of FUO. The records of patients admitted to Sheba Medical Center between January 2013 and January 2018 who underwent 18FDG-PET/CT for the evaluation of FUO were reviewed. Following examination of available medical test results, 18FDG-PET/CT findings were assessed to determine whether lesions identified proved diagnostic. Of 225 patients who underwent 18FDG-PET/CT for FUO work-up, 128 (57%) met inclusion criteria. Eighty (62.5%) were males; mean age was 59 ± 20.3 (range: 18–93). A final diagnosis was made in 95 (74%) patients. Of the 128 18FDG-PET/CT tests conducted for the workup of FUO, 61 (48%) were true positive, 26 (20%) false positive, 26 (20%) true negative, and 15 (12%) false negative. In a multivariate analysis, weight loss and anemia were independently associated with having a contributary results of 18FDG-PET/CT. The test yielded a sensitivity of 70%, specificity of 37%, positive predictive value of 70%, and negative predictive value of 37%. 18FDG-PET/CT is a valuable tool in the diagnostic workup of FUO. It proved effective in diagnosing almost half the patients, especially in those with anemia and weight loss.

Imaging a Fever—Redefining the Role of 2-deoxy-2-[18F]Fluoro-D-Glucose–Positron Emission Tomography/Computed Tomography in Fever of Unknown Origin Investigations

2020 ◽  
Author(s):  
William F Wright ◽  
Paul G Auwaerter ◽  
Elizabeth H Dibble ◽  
Steven P Rowe ◽  
Philip A Mackowiak
Keyword(s):  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Fever Of Unknown Origin ◽  
Imaging Technique ◽  
Unknown Origin ◽  
Emission Tomography ◽  
18Fdg Pet ◽  
Positron Emission ◽  
Pet Ct ◽  
Abnormal Uptake

Abstract Growing evidence suggests that 2-deoxy-2-[18F]fluoro-D-glucose (18FDG)–positron emission tomography/computed tomography (PET/CT) is a useful imaging technique for the evaluation of fever of unknown origin (FUO). This imaging technique allows for accurate localization of foci of hypermetabolism based on 18FDG uptake in glycolytically active cells that may represent inflammation, infection, or neoplasia. The presence of abnormal uptake can help direct further investigation that may yield a final diagnosis. A lack of abnormal uptake can be reasonably reassuring that these conditions are not present, thereby avoiding unnecessary additional testing. Insurers have not routinely covered outpatient 18FDG-PET/CT for the indication of FUO in the United States. However, data published since 2007 suggest early use in FUO diagnostic evaluations improves diagnostic efficiency and reduces costs. Clinicians and insurers should consider 18FDG-PET/CT as a useful tool when preliminary studies are unrevealing.

Diagnostic value of [18F]-FDG PET/CT in children with fever of unknown origin or unexplained signs of inflammation

2009 ◽  
Vol 37 (1) ◽  
pp. 136-145 ◽  
Author(s):  
Niklas Jasper ◽  
Jan Däbritz ◽  
Michael Frosch ◽  
Markus Loeffler ◽  
Matthias Weckesser ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Diagnostic Value ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Diagnostic Value of 18F-FDG PET/CT vs. Chest-Abdomen-Pelvis CT Scan in Management of Patients with Fever of Unknown Origin, Inflammation of Unknown Origin or Episodic Fever of Unknown Origin: A Comparative Multicentre Prospective Study

2022 ◽  
Vol 11 (2) ◽  
pp. 386
Author(s):  
Kim-Heang Ly ◽  
Nathalie Costedoat-Chalumeau ◽  
Eric Liozon ◽  
Stéphanie Dumonteil ◽  
Jean-Pierre Ducroix ◽  
...  
Keyword(s):  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Diagnostic Value ◽  
University Hospital ◽  
Emission Tomography ◽  
Positron Emission ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Multicentre Prospective Study

Fluorodesoxyglucose Positron Emission Tomography (PET/CT) has never been compared to Chest-Abdomen-Pelvis CT (CAPCT) in patients with a fever of unknown origin (FUO), inflammation of unknown origin (IUO) and episodic fever of unknown origin (EFUO) through a prospective and multicentre study. In this study, we investigated the diagnostic value of PET/CT compared to CAPCT in these patients. The trial was performed between 1 May 2008 through 28 February 2013 with 7 French University Hospital centres. Patients who fulfilled the FUO, IUO or EFUO criteria were included. Diagnostic orientation (DO), diagnostic contribution (DC) and time for diagnosis of both imaging resources were evaluated. One hundred and three patients were included with 35 FUO, 35 IUO and 33 EFUO patients. PET/CT showed both a higher DO (28.2% vs. 7.8%, p < 0.001) and DC (19.4% vs. 5.8%, p < 0.001) than CAPCT and reduced the time for diagnosis in patients (3.8 vs. 17.6 months, p = 0.02). Arthralgia (OR 4.90, p = 0.0012), DO of PET/CT (OR 4.09, p = 0.016), CRP > 30 mg/L (OR 3.70, p = 0.033), and chills (OR 3.06, p = 0.0248) were associated with the achievement of a diagnosis (Se: 89.1%, Sp: 56.8%). PET/CT both orients and contributes to diagnoses at a higher rate than CAPCT, especially in patients with FUO and IUO, and reduces the time for diagnosis.

2-[18F]FDG PET/CT in Fever of Unknown Origin

2021 ◽  
pp. 209-216
Author(s):  
Ilse J. E. Kouijzer ◽  
Chantal P. Bleeker-Rovers ◽  
Lioe-Fee de Geus-Oei
Keyword(s):  
Fdg Pet ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct
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