scholarly journals Validity of Targeted Next-Generation Sequencing in Routine Care for Identifying Clinically Relevant Molecular Profiles in Non–Small-Cell Lung Cancer

2018 ◽  
Vol 20 (4) ◽  
pp. 550-564 ◽  
Author(s):  
Antoine Legras ◽  
Marc Barritault ◽  
Anne Tallet ◽  
Elizabeth Fabre ◽  
Alice Guyard ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Next Generation Sequencing ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Routine Care ◽  
Small Cell ◽  
Small Cell Lung ◽  
Targeted Next Generation Sequencing ◽  
Molecular Profiles ◽  
Generation Sequencing

Abstract 610: Prospective genomic characterization of small cell lung cancer by targeted next generation sequencing

2015 ◽  
Author(s):  
Helen H. Won ◽  
M. Catherine Pietanza ◽  
Lee M. Krug ◽  
Anna M. Varghese ◽  
Natasha Rekhtman ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Next Generation Sequencing ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Targeted Next Generation Sequencing ◽  
Genomic Characterization ◽  
Generation Sequencing

scholarly journals Mutational profile by targeted next generation sequencing of non-small cell lung cancer in the Mexican population

2019 ◽  
Vol 61 (3, may-jun) ◽  
pp. 308
Author(s):  
Norma Hernández-Pedro ◽  
Giovanny Soca-Chafre ◽  
Carmen Alaez-Versón ◽  
Karol Carrillo-Sánchez ◽  
Alejandro Avilés-Salas ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Next Generation Sequencing ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Somatic Mutations ◽  
Small Cell ◽  
Mexican Population ◽  
Small Cell Lung ◽  
Targeted Next Generation Sequencing ◽  
Generation Sequencing

Objective. Targeted next-generation sequencing (t-NGS) has revolutionized clinical diagnosis allowing multiplexed de­tection of genomic alterations. This study evaluated the profile of somatic mutations by t-NGS in Mexican patients with non-small cell lung cancer (NSCLC). Materials and methods. Genomic DNA was extracted from 90 lung adenocarcinomas and sequences were generated for a panel of 48 cancer ge­nes. Epidermal Growth Factor Receptor (EGFR) mutations were detected in parallel by quantitative PCR. Results. The mutational profile of NSCLC revealed alterations in 27 genes, where TP53 (47.8%) and EGFR (36.7%) exhibited the highest mutation rates. EGFR Q787 mutations were present in 14 cases (15.6%), 10 cases had exon 19 deletions (11.1%), seven cases had L858R (7.8%). The mutational frequency for genes like EGFR, MET, HNF1A, HER2 and GUSB was different compared to caucasian population. Conclusion. t-NGS improved NSCLC treatments efficacy due to its sensitivity and specificity. A distinct pattern of somatic mutations was found in Mexican population. 

scholarly journals Targeted next-generation sequencing reveals recurrence-associated genomic alterations in early-stage non-small cell lung cancer

Oncotarget ◽  
2018 ◽  
Vol 9 (91) ◽  
pp. 36344-36357 ◽  
Author(s):  
William C.S. Cho ◽  
Kien Thiam Tan ◽  
Victor W.S. Ma ◽  
Jacky Y.C. Li ◽  
Roger K.C. Ngan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Next Generation Sequencing ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Early Stage ◽  
Small Cell ◽  
Small Cell Lung ◽  
Genomic Alterations ◽  
Targeted Next Generation Sequencing ◽  
Generation Sequencing

468 Validity of next generation sequencing in routine care for non-small cell lung cancer diagnosis

2015 ◽  
Vol 51 ◽  
pp. S101-S102
Author(s):  
A. Legras ◽  
N. Pecuchet ◽  
A. Tallet ◽  
A. Guyard ◽  
A. Mansuet-Lupo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Next Generation Sequencing ◽  
Small Cell Lung Cancer ◽  
Cancer Diagnosis ◽  
Cell Lung Cancer ◽  
Routine Care ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer Diagnosis ◽  
Generation Sequencing

scholarly journals Mutational profile of non-small cell lung cancer by targeted next-generation sequencing in the Mexican population

2016 ◽  
Vol 11 (2) ◽  
pp. S24-S25
Author(s):  
Giovanny Socca ◽  
Carmen Alaez ◽  
Norma Hernandez-Pedro ◽  
Pedro A. Barrios-Bernal ◽  
Karol Carrillo-Sanchez ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Next Generation Sequencing ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Mexican Population ◽  
Next Generation ◽  
Small Cell Lung ◽  
Targeted Next Generation Sequencing ◽  
Generation Sequencing
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