scholarly journals Targeted next-generation sequencing reveals recurrence-associated genomic alterations in early-stage non-small cell lung cancer

Oncotarget ◽  
2018 ◽  
Vol 9 (91) ◽  
pp. 36344-36357 ◽  
Author(s):  
William C.S. Cho ◽  
Kien Thiam Tan ◽  
Victor W.S. Ma ◽  
Jacky Y.C. Li ◽  
Roger K.C. Ngan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Next Generation Sequencing ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Early Stage ◽  
Small Cell ◽  
Small Cell Lung ◽  
Genomic Alterations ◽  
Targeted Next Generation Sequencing ◽  
Generation Sequencing

Application of next-generation sequencing (NGS) to reveal targetable genomic alterations (GA) in patients with non-small cell lung cancer (NSCLC).

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. e19159-e19159
Author(s):  
Alexey Barinov ◽  
Ilya Gagarin ◽  
Irina Demidova ◽  
Nikita Savelov ◽  
Vyacheslav Grinevich ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Next Generation Sequencing ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Next Generation ◽  
Small Cell Lung ◽  
Genomic Alterations ◽  
Next Generation Sequencing Ngs ◽  
Generation Sequencing

Landscape of genomic alterations (GA) detected by next-generation sequencing (NGS) in non-small cell lung cancer (NSCLC) adenocarcinoma in Israel.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. e19111-e19111
Author(s):  
Nir Peled ◽  
Hovav Nechushtan ◽  
Mira Wollner ◽  
Amir Onn ◽  
Dov Flex ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Next Generation Sequencing ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Next Generation ◽  
Small Cell Lung ◽  
Genomic Alterations ◽  
Next Generation Sequencing Ngs ◽  
Generation Sequencing

Evaluation of Tumor-Derived Exosomal miRNA as Potential Diagnostic Biomarkers for Early-Stage Non–Small Cell Lung Cancer Using Next-Generation Sequencing

2017 ◽  
Vol 23 (17) ◽  
pp. 5311-5319 ◽  
Author(s):  
Xiance Jin ◽  
Yanfan Chen ◽  
Hanbin Chen ◽  
Shaoran Fei ◽  
Didi Chen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Next Generation Sequencing ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Early Stage ◽  
Small Cell ◽  
Small Cell Lung ◽  
Diagnostic Biomarkers ◽  
Exosomal Mirna ◽  
Generation Sequencing

Abstract 610: Prospective genomic characterization of small cell lung cancer by targeted next generation sequencing

2015 ◽  
Author(s):  
Helen H. Won ◽  
M. Catherine Pietanza ◽  
Lee M. Krug ◽  
Anna M. Varghese ◽  
Natasha Rekhtman ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Next Generation Sequencing ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Targeted Next Generation Sequencing ◽  
Genomic Characterization ◽  
Generation Sequencing

scholarly journals Mutational profile by targeted next generation sequencing of non-small cell lung cancer in the Mexican population

2019 ◽  
Vol 61 (3, may-jun) ◽  
pp. 308
Author(s):  
Norma Hernández-Pedro ◽  
Giovanny Soca-Chafre ◽  
Carmen Alaez-Versón ◽  
Karol Carrillo-Sánchez ◽  
Alejandro Avilés-Salas ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Next Generation Sequencing ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Somatic Mutations ◽  
Small Cell ◽  
Mexican Population ◽  
Small Cell Lung ◽  
Targeted Next Generation Sequencing ◽  
Generation Sequencing

Objective. Targeted next-generation sequencing (t-NGS) has revolutionized clinical diagnosis allowing multiplexed de­tection of genomic alterations. This study evaluated the profile of somatic mutations by t-NGS in Mexican patients with non-small cell lung cancer (NSCLC). Materials and methods. Genomic DNA was extracted from 90 lung adenocarcinomas and sequences were generated for a panel of 48 cancer ge­nes. Epidermal Growth Factor Receptor (EGFR) mutations were detected in parallel by quantitative PCR. Results. The mutational profile of NSCLC revealed alterations in 27 genes, where TP53 (47.8%) and EGFR (36.7%) exhibited the highest mutation rates. EGFR Q787 mutations were present in 14 cases (15.6%), 10 cases had exon 19 deletions (11.1%), seven cases had L858R (7.8%). The mutational frequency for genes like EGFR, MET, HNF1A, HER2 and GUSB was different compared to caucasian population. Conclusion. t-NGS improved NSCLC treatments efficacy due to its sensitivity and specificity. A distinct pattern of somatic mutations was found in Mexican population. 

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