Characterization of the hemodynamic response in the rat lumbar spinal cord using intrinsic optical imaging and laser speckle

The aim of this study was to characterizein vivomeasurements of diffusion along the length of the entire healthy spinal cord and to compare DTI indices, including fractional anisotropy (FA) and mean diffusivity (MD), between cord regions. The objective is to determine whether or not there are significant differences in DTI indices along the cord that must be considered for future applications of characterizing the effects of injury or disease. A cardiac gated, single-shot EPI sequence was used to acquire diffusion-weighted images of the cervical, thoracic, and lumbar regions of the spinal cord in nine neurologically intact subjects (19 to 22 years). For each cord section, FA versus MD values were plotted, and a k-means clustering method was applied to partition the data according to tissue properties. FA and MD values from both white matter (averageFA=0.69, averageMD=0.93×10−3 mm2/s) and grey matter (averageFA=0.44, averageMD=1.8×10−3 mm2/s) were relatively consistent along the length of the cord.

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Intrinsic Optical Imaging Of The Rat Lumbar Spinal Cord

10.1364/biomed.2008.bmd7 ◽

2008 ◽

Author(s):

N. Brieu ◽

E. Beaumont ◽

F. Lesage

Keyword(s):

Spinal Cord ◽

Optical Imaging ◽

Lumbar Spinal Cord ◽

Lumbar Spinal

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Characterization of [3H]Rauwolscine binding to alpha2-adrenoceptor sites in the lumbar spinal cord of the cat: Comparison to such binding sites in the cat frontal cerebral cortex

Brain Research ◽

10.1016/0006-8993(86)91045-0 ◽

1986 ◽

Vol 368 (1) ◽

pp. 87-100 ◽

Cited By ~ 11

Author(s):

James R. Howe ◽

Tony L. Yaksh

Keyword(s):

Spinal Cord ◽

Cerebral Cortex ◽

Binding Sites ◽

Lumbar Spinal Cord ◽

Frontal Cerebral Cortex ◽

Alpha2 Adrenoceptor ◽

Lumbar Spinal

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Characterization of locomotor-related GABAergic interneurons in the ventrolateral lumbar spinal cord in the developing mouse

Neuroscience Research ◽

10.1016/j.neures.2010.07.1664 ◽

2010 ◽

Vol 68 ◽

pp. e375

Author(s):

Hiroshi Nishimaru ◽

Miyo Kakizaki ◽

Yuchio Yanagawa

Keyword(s):

Spinal Cord ◽

Lumbar Spinal Cord ◽

Gabaergic Interneurons ◽

Lumbar Spinal

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Lipomeningocele associated with diplomyelia in a dog

Tierärztliche Praxis Ausgabe K Kleintiere / Heimtiere ◽

10.15654/tpk-170751 ◽

2018 ◽

Vol 46 (05) ◽

pp. 323-329 ◽

Cited By ~ 2

Author(s):

Nele Ondreka ◽

Sara Malberg ◽

Emma Laws ◽

Martin Schmidt ◽

Sabine Schulze

Keyword(s):

Spinal Cord ◽

Neurological Status ◽

Split Cord Malformation ◽

Lumbar Spinal Cord ◽

Histopathological Diagnosis ◽

Type I ◽

Thoracic Spinal Cord ◽

Thoracic Spinal ◽

Subcutaneous Mass ◽

Lumbar Spinal

SummaryA 2-year-old male neutered mixed breed dog with a body weight of 30 kg was presented for evaluation of a soft subcutaneous mass on the dorsal midline at the level of the caudal thoracic spine. A further clinical sign was intermittent pain on palpation of the area of the subcutaneous mass. The owner also described a prolonged phase of urination with repeated interruption and re-initiation of voiding. The findings of the neurological examination were consistent with a lesion localization between the 3rd thoracic and 3rd lumbar spinal cord segments. Magnetic resonance imaging revealed a spina bifida with a lipomeningocele and diplomyelia (split cord malformation type I) at the level of thoracic vertebra 11 and 12 and secondary syringomyelia above the aforementioned defects in the caudal thoracic spinal cord. Surgical resection of the lipomeningocele via a hemilaminectomy was performed. After initial deterioration of the neurological status postsurgery with paraplegia and absent deep pain sensation the dog improved within 2 weeks to non-ambulatory paraparesis with voluntary urination. Six weeks postoperatively the dog was ambulatory, according to the owner. Two years after surgery the owner recorded that the dog showed a normal gait, a normal urination and no pain. Histopathological diagnosis of the biopsied material revealed a lipomeningocele which confirmed the radiological diagnosis.

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