scholarly journals Substance P downregulates expression of the high affinity IgE receptor (FcεRI) by human mast cells

2010 ◽  
Vol 220 (1-2) ◽  
pp. 17-24 ◽  
Author(s):  
Christine McCary ◽  
Brian P. Tancowny ◽  
Adriana Catalli ◽  
Leslie C. Grammer ◽  
Kathleen E. Harris ◽  
...  
Keyword(s):  
Mast Cells ◽  
Substance P ◽  
Ige Receptor ◽  
High Affinity ◽  
Human Mast Cells ◽  
High Affinity Ige Receptor

scholarly journals High-affinity IgE receptor-β chain expression in human mast cells

2008 ◽  
Vol 336 (2) ◽  
pp. 229-234 ◽  
Author(s):  
Akira Matsuda ◽  
Yoshimichi Okayama ◽  
Nobuyuki Ebihara ◽  
Norihiko Yokoi ◽  
Peisong Gao ◽  
...  
Keyword(s):  
Mast Cells ◽  
Ige Receptor ◽  
High Affinity ◽  
Human Mast Cells ◽  
High Affinity Ige Receptor ◽  
Β Chain

Cultured Human Mast Cells Are Heterogeneous for Expression of the High-Affinity IgE Receptor FcεRI

2012 ◽  
Vol 157 (3) ◽  
pp. 246-250 ◽  
Author(s):  
Hans Jürgen Hoffmann ◽  
Pernille Munk Frandsen ◽  
Lars Harder Christensen ◽  
Peter Oluf Schiøtz ◽  
Ronald Dahl
Keyword(s):  
Mast Cells ◽  
Ige Receptor ◽  
High Affinity ◽  
Human Mast Cells ◽  
High Affinity Ige Receptor

scholarly journals Induction of the high-affinity IgE receptor (FcɛRI) on human mast cells by IL-4

1996 ◽  
Vol 8 (9) ◽  
pp. 1367-1373 ◽  
Author(s):  
Hano Toru, Chisel Ra ◽  
Shigeaki Nonoyama ◽  
Katsuhiro Suzuki ◽  
Jun-ichi Yata ◽  
Tatsutoshi Nakahata ◽  
...  
Keyword(s):  
Mast Cells ◽  
Ige Receptor ◽  
High Affinity ◽  
Human Mast Cells ◽  
High Affinity Ige Receptor

Cultured Human Mast Cells are heterogeneous for expression of the High Affinity IgE Receptor FcεRI

2011 ◽  
Vol 127 (2) ◽  
pp. AB133-AB133 ◽  
Author(s):  
H. Hoffmann ◽  
P. Munk Frandsen ◽  
L. Harder Christensen ◽  
R. Dahl ◽  
P. Schiøtz
Keyword(s):  
Mast Cells ◽  
Ige Receptor ◽  
High Affinity ◽  
Human Mast Cells ◽  
High Affinity Ige Receptor

scholarly journals Extracellular Signal-Regulated Kinases 1 and 2 Phosphorylate Gab2 To Promote a Negative-Feedback Loop That Attenuates Phosphoinositide 3-Kinase/Akt Signaling

2017 ◽  
Vol 37 (7) ◽  
Author(s):  
Xiaocui Zhang ◽  
Geneviève Lavoie ◽  
Antoine Méant ◽  
Léo Aubert ◽  
Marie Cargnello ◽  
...  
Keyword(s):  
Mast Cells ◽  
Negative Feedback ◽  
Feedback Loop ◽  
Akt Signaling ◽  
Negative Feedback Loop ◽  
Ige Receptor ◽  
High Affinity ◽  
Extracellular Signal ◽  
Phosphoinositide 3 Kinase ◽  
High Affinity Ige Receptor

ABSTRACT The scaffolding adapter protein Gab2 (Grb2-associated binder) promotes cell proliferation, survival, and motility by engaging several signaling pathways downstream of growth factor and cytokine receptors. In particular, Gab2 plays essential roles in mast cells, as it is required for phosphoinositide 3-kinase (PI3K) activation in response to Kit and the high-affinity IgE receptor. While the positive role of Gab2 in PI3K signaling is well documented, very little is known about the mechanisms that attenuate its function. Here we show that Gab2 becomes phosphorylated on multiple proline-directed sites upon stimulation of the Ras/extracellular signal-regulated kinase (ERK) signaling pathway. We demonstrate that ERK1 and ERK2 interact with Gab2 via a novel docking motif, which is required for subsequent Gab2 phosphorylation in response to ERK1/2 activation. We identified four ERK1/2-dependent phosphorylation sites in Gab2 that prevent the recruitment of the p85 regulatory subunit of PI3K. Using bone marrow-derived mast cells to study Gab2-dependent signaling, we found that the inhibition of ERK1/2 activity promotes Akt signaling in response to Kit and the high-affinity IgE receptor. Together, our results indicate that ERK1/2 participates in a negative-feedback loop that attenuates PI3K/Akt signaling in response to various agonists.

scholarly journals A Minor Catalytic Activity of Src Family Kinases Is Sufficient for Maximal Activation of Mast Cells via the High-Affinity IgE Receptor

2009 ◽  
Vol 184 (1) ◽  
pp. 84-93 ◽  
Author(s):  
Michael Poderycki ◽  
Yoshiaki Tomimori ◽  
Tomoaki Ando ◽  
Wenbin Xiao ◽  
Mari Maeda-Yamamoto ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Mast Cells ◽  
Src Family Kinases ◽  
Ige Receptor ◽  
High Affinity ◽  
Maximal Activation ◽  
A Minor ◽  
High Affinity Ige Receptor

scholarly journals Regulation of the Tyrosine Phosphorylation of Phospholipid Scramblase 1 in Mast Cells That Are Stimulated through the High-Affinity IgE Receptor

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e109800 ◽  
Author(s):  
Asma Kassas ◽  
Ivan C. Moura ◽  
Yumi Yamashita ◽  
Jorg Scheffel ◽  
Claudine Guérin-Marchand ◽  
...  
Keyword(s):  
Mast Cells ◽  
Tyrosine Phosphorylation ◽  
Ige Receptor ◽  
Phospholipid Scramblase ◽  
High Affinity ◽  
High Affinity Ige Receptor ◽  
Phospholipid Scramblase 1
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