<p>Multiple myeloma (MM) is a malignant proliferation of abnormal plasma cell tumour that often violates multiple body systems. Its clinical manifestations vary greatly, thus leading to a high rate of misdiagnosis. Herein, we report a clinical case of non-compressive spinal cord lesion, which manifested early signs of multiple myeloma. Retrospective analyses of MM pathogenesis, clinical manifestation, and diagnosis were based on the clinical features and diagnostic criteria of MM that have been published in the literature. This study was initiated to improve current awareness of MM and to reduce the rate of misdiagnosis. </p>