Assessment of autonomic nervous system function in type 2 diabetes a war of new era

Aims. The Aim of the present study was to examine whether there is a relationship between autonomic nervous system function and glycemic variability (GV) in patients with type 2 diabetes (T2D).Methods. A total of 50 (29 males) patients with T2D (mean age 58.4 ± 9.9 years, median diabetes duration 5.5 [IQR 2.0–9.25] years), on oral antidiabetic agents, underwent ECG recording and subcutaneous glucose monitoring, simultaneously and continuously, for 24 hours.Results. After adjustment for HbA1c and diabetes duration, total power of heart rate variability (HRV) was inversely associated with the standard deviation of the mean interstitial tissue glucose (MITG) and with theM-value during the entire recording (r: −0.29,P=0.052;r: −0.30,P=0.047, resp.) and during the night (r: −0.29,P=0.047;r: −0.31,P=0.03, resp.). Most of the HRV time-domain indices were significantly correlated with standard deviation of the MITG and theM-value. These correlations were stronger for the HRV recordings during the night. No significant association was found between HRV parameters and MAGE.Conclusions. HRV is inversely associated with GV in patients with T2D, which might be a sign of causation between GV and autonomic dysfunction. Prospective studies are needed to further investigate the importance of GV in the pathogenesis of long-term complications of diabetes.

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Prospective Investigation of Autonomic Nervous System Function and the Development of Type 2 Diabetes

Circulation ◽

10.1161/01.cir.0000066324.74807.95 ◽

2003 ◽

Vol 107 (17) ◽

pp. 2190-2195 ◽

Cited By ~ 169

Author(s):

Mercedes R. Carnethon ◽

Sherita H. Golden ◽

Aaron R. Folsom ◽

William Haskell ◽

Duanping Liao

Keyword(s):

Type 2 Diabetes ◽

Nervous System ◽

Autonomic Nervous System ◽

System Function ◽

Autonomic Nervous System Function ◽

Autonomic Nervous ◽

Nervous System Function ◽

Prospective Investigation

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Assessment of the autonomic nervous system function in infants: the pupillary light reflex: normative data and physiological observations

Neuropediatrics ◽

10.1055/s-2006-953616 ◽

2006 ◽

Vol 37 (03) ◽

Author(s):

E Longin ◽

N Shazi ◽

C Dimitrios ◽

T Gerstner ◽

T Lenz ◽

...

Keyword(s):

Nervous System ◽

Autonomic Nervous System ◽

Normative Data ◽

Pupillary Light Reflex ◽

System Function ◽

Autonomic Nervous System Function ◽

Light Reflex ◽

Autonomic Nervous ◽

Pupillary Light ◽

Nervous System Function

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Is Active Lifestyle Related to Autonomic Nervous System Function and Lipid Profile in People with Overweight? A Study Pilot

Sustainability ◽

10.3390/su13052439 ◽

2021 ◽

Vol 13 (5) ◽

pp. 2439

Author(s):

Alexis Espinoza-Salinas ◽

Edgardo Molina-Sotomayor ◽

Johnattan Cano-Montoya ◽

Jose Antonio Gonzalez-Jurado

Keyword(s):

Physical Activity ◽

Insulin Resistance ◽

Nervous System ◽

Autonomic Nervous System ◽

Lipid Profile ◽

Model Assessment ◽

System Function ◽

Autonomic Nervous System Function ◽

Autonomic Nervous ◽

Nervous System Function

Autonomic nervous system function is an important predictor of physical fitness. The objective of this study was to find out the associations of autonomic activity parameters, lipid profile, insulin concentrations, and insulin resistance in overweight men with the level of physical activity. A descriptive and correlational study was carried out in 28 overweight men: 14 physically active (PA) and 14 physically inactive (PI). The following variables were assessed: Level of physical activity, HRV (heart rate variability), basal insulin, HOMA-IR index (Homeostasis Model Assessment Insulin-Resistance), and lipid profile. The main results show a positive correlation between the spectral parameters of the HRV and total cholesterol (r = 0.24), LDL (r = 0.59), VLDL (r = 0.86), and insulin (r = 0.88) of sedentary people, evidencing a directly proportional correlation with BMI. We conclude that weight gain and a sedentary lifestyle are associated with an increase in sympathetic discharge, which, in turn, is associated with an increase in lipid profile and insulin levels.

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