Susceptibility to intestinal tumorigenesis in folate-deficient mice may be influenced by variation in one-carbon metabolism and DNA repair

2011 ◽  
Vol 22 (11) ◽  
pp. 1022-1029 ◽  
Author(s):  
Erin Knock ◽  
Liyuan Deng ◽  
Natalia Krupenko ◽  
Ryan D. Mohan ◽  
Qing Wu ◽  
...  
Keyword(s):  
Dna Repair ◽  
Carbon Metabolism ◽  
Intestinal Tumorigenesis ◽  
One Carbon Metabolism ◽  
Deficient Mice

scholarly journals One-carbon metabolism supplementation improves outcome after stroke in aged male MTHFR-deficient mice

2019 ◽  
Vol 132 ◽  
pp. 104613 ◽  
Author(s):  
Nafisa M. Jadavji ◽  
Hannah Mosnier ◽  
Erin Kelly ◽  
Kamaya Lawrence ◽  
Sarah Cruickshank ◽  
...  
Keyword(s):  
Carbon Metabolism ◽  
One Carbon Metabolism ◽  
Deficient Mice

Genetic Variants in One-carbon Metabolism and DNA Repair Genes Modify the Association between Arsenic and Skin Lesions in Bangladesh

2013 ◽  
Vol 2013 (1) ◽  
pp. 2951
Author(s):  
Wei Jie Seow ◽  
Wen-Chi Pan ◽  
Molly Kile ◽  
Andrea A Baccarelli ◽  
Quazi Quamruzzaman ◽  
...  
Keyword(s):  
Dna Repair ◽  
Carbon Metabolism ◽  
Genetic Variants ◽  
Skin Lesions ◽  
Dna Repair Genes ◽  
One Carbon Metabolism ◽  
Repair Genes

scholarly journals Disruption of hepatic one-carbon metabolism impairs mitochondrial function and enhances macrophage activity in methionine–choline-deficient mice

2020 ◽  
Vol 81 ◽  
pp. 108381 ◽  
Author(s):  
Brandon J. Eudy ◽  
Caitlin E. McDermott ◽  
Gabriel Fernandez ◽  
Clayton E. Mathews ◽  
Jinping Lai ◽  
...  
Keyword(s):  
Mitochondrial Function ◽  
Carbon Metabolism ◽  
Macrophage Activity ◽  
One Carbon Metabolism ◽  
Deficient Mice

Genetic Variation: Impact on Folate (and Choline) Bioefficacy

2010 ◽  
Vol 80 (45) ◽  
pp. 319-329 ◽  
Author(s):  
Allyson A. West ◽  
Marie A. Caudill
Keyword(s):  
Carbon Metabolism ◽  
Genetic Variants ◽  
Plasma Homocysteine ◽  
Water Soluble ◽  
Gene Interactions ◽  
Dietary Folate ◽  
Methyl Donors ◽  
Common Genetic Variants ◽  
One Carbon Metabolism ◽  
The Impact

Folate and choline are water-soluble micronutrients that serve as methyl donors in the conversion of homocysteine to methionine. Inadequacy of these nutrients can disturb one-carbon metabolism as evidenced by alterations in circulating folate and/or plasma homocysteine. Among common genetic variants that reside in genes regulating folate absorptive and metabolic processes, homozygosity for the MTHFR 677C > T variant has consistently been shown to have robust effects on status markers. This paper will review the impact of genetic variants in folate-metabolizing genes on folate and choline bioefficacy. Nutrient-gene and gene-gene interactions will be considered along with the need to account for these genetic variants when updating dietary folate and choline recommendations.

scholarly journals Effect of a Tailored Dietary Intervention with High or Standard Protein Intake on B-Vitamin and One Carbon Metabolism Status in Healthy Older Males: A 10 Week Randomised Controlled Trial

Proceedings ◽  
2019 ◽  
Vol 8 (1) ◽  
pp. 19
Author(s):  
Nicola Gillies ◽  
Amber M. Milan ◽  
Pankaja Sharma ◽  
Brenan Durainayagam ◽  
Sarah M. Mitchell ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Carbon Metabolism ◽  
Protein Intake ◽  
Dietary Intervention ◽  
Controlled Trial ◽  
One Carbon Metabolism ◽  
Randomised Controlled ◽  
B Vitamin ◽  
Standard Protein ◽  
Older Males

Background: Maintaining optimal status of folate and metabolically [...]

One carbon (metabolism) to rule T cell identity

2021 ◽  
Vol 21 (4) ◽  
pp. 206-206
Author(s):  
Felix Clemens Richter ◽  
Alexander J. Clarke
Keyword(s):  
T Cell ◽  
Carbon Metabolism ◽  
Cell Identity ◽  
One Carbon Metabolism

Nutrition, One-Carbon Metabolism and Arsenic Methylation

Toxicology ◽  
2021 ◽  
pp. 152803
Author(s):  
Ahlam Abuawad ◽  
Anne K. Bozack ◽  
Roheeni Saxena ◽  
Mary V. Gamble
Keyword(s):  
Carbon Metabolism ◽  
Arsenic Methylation ◽  
One Carbon Metabolism
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