Flavokawain B inhibits growth of human squamous carcinoma cells: Involvement of apoptosis and cell cycle dysregulation in vitro and in vivo

2012 ◽  
Vol 23 (4) ◽  
pp. 368-378 ◽  
Author(s):  
Elong Lin ◽  
Wen-Hsin Lin ◽  
Sheng-Yang Wang ◽  
Chih-Sheng Chen ◽  
Jiuun-Wang Liao ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Squamous Carcinoma ◽  
Carcinoma Cells ◽  
Squamous Carcinoma Cells

scholarly journals Apoptotic Effects of Diosgeninlactoside on Oral Squamous Carcinoma Cells in Vitro and in Vivo

2014 ◽  
Vol 37 (9) ◽  
pp. 1450-1459 ◽  
Author(s):  
Xu Wang ◽  
Chongkui Sun ◽  
Shiliang He ◽  
Xiurong Guo ◽  
Hao Xu ◽  
...  
Keyword(s):  
Squamous Carcinoma ◽  
Carcinoma Cells ◽  
Squamous Carcinoma Cells ◽  
Oral Squamous Carcinoma ◽  
Apoptotic Effects

Phototherapy with Argon Lasers and Rhodamine-123 for Tumor Eradication

1988 ◽  
Vol 98 (6) ◽  
pp. 581-588 ◽  
Author(s):  
Dan J. Castro ◽  
Romaine E. Saxton ◽  
Harold R. Fetterman ◽  
Donna J. Castro ◽  
Paul H. Ward
Keyword(s):  
Laser Treatment ◽  
Test Group ◽  
Squamous Carcinoma ◽  
Argon Laser ◽  
Carcinoma Cells ◽  
Rhodamine 123 ◽  
Complete Regression ◽  
Squamous Carcinoma Cells

The effectiveness of Rhodamine-123 (Rh-123) as a new photochemosensitizing agent for the argon laser treatment of human melanoma and squamous carcinoma cells in vitro was recently demonstrated. In this study, a new technique of “rosette” treatment with the argon laser was developed to completely eradicate human squamous carcinoma (P3) tumor transplants in nude mice after chemosensitization with Rh-123. Each group included four nu/nu mice injected subcutaneously with 107 P3 carcinoma cells/site for a total of 48 sites. Tumor take was >95% at one week, with >10 mm3 tumor volume at each site. Test groups were sensitized with Rh-123 (1 μg/ml for 1 hour) by intratumor or intraperitoneal injection at 1 week and then treated with the argon laser at 514.5 nm. To allow uniform delivery of energies to the tumor and its edges, a new “rosette” technique was developed. The tumors were then exposed to nonthermal levels of 700 J/cm2 (36°C) or 950 J/cm2 (40°C) as determined by a new and reproducible method of dosimetry. All 16 tumors in this test group showed complete regression with excellent wound healing at 2 weeks and no recurrences, even after an 8 week followup. These results demonstrate that effective eradication of tumors can be achieved in vivo only after sensitization with Rh-123 and specific argon laser treatment (“rosette”), even at nonthermal levels of energies. The high effectiveness of this technique and low toxicity of Rh-123 may render its clinical use very attractive for the treatment of superficial malignancies.

Riccardin D-26, a synthesized macrocyclic bisbibenzyl compound, inhibits human oral squamous carcinoma cells KB and KB/VCR: In vitro and in vivo studies

2013 ◽  
Vol 1830 (1) ◽  
pp. 2194-2203 ◽  
Author(s):  
Bin Yue ◽  
Cui-Rong Zhao ◽  
Hui-Min Xu ◽  
Yuan-Yuan Li ◽  
Yan-Na Cheng ◽  
...  
Keyword(s):  
Squamous Carcinoma ◽  
Carcinoma Cells ◽  
In Vivo Studies ◽  
Squamous Carcinoma Cells ◽  
Oral Squamous Carcinoma

Galangin inhibits growth of human head and neck squamous carcinoma cells in vitro and in vivo

2014 ◽  
Vol 224 ◽  
pp. 149-156 ◽  
Author(s):  
Liping Zhu ◽  
Qingqiong Luo ◽  
Jianjun Bi ◽  
Jieying Ding ◽  
Shengfang Ge ◽  
...  
Keyword(s):  
Head And Neck ◽  
Squamous Carcinoma ◽  
Human Head ◽  
Carcinoma Cells ◽  
Squamous Carcinoma Cells

Activation of Toll-like receptor 3 induces apoptosis of oral squamous carcinoma cells in vitro and in vivo

2012 ◽  
Vol 44 (8) ◽  
pp. 1266-1275 ◽  
Author(s):  
Qingqiong Luo ◽  
Shuiqing Hu ◽  
Ming Yan ◽  
Zujun Sun ◽  
Wantao Chen ◽  
...  
Keyword(s):  
Squamous Carcinoma ◽  
Carcinoma Cells ◽  
Toll Like Receptor ◽  
Squamous Carcinoma Cells ◽  
Oral Squamous Carcinoma

Utilizing ICG Spectroscopical Properties for Real-Time Nanoparticle Release Quantification In vitro and In vivo in Imaging Setups

2020 ◽  
Vol 26 (31) ◽  
pp. 3828-3833 ◽  
Author(s):  
Tuula Peñate-Medina ◽  
Eike Kraas ◽  
Kunliang Luo ◽  
Jana Humbert ◽  
Hanwen Zhu ◽  
...  
Keyword(s):  
Release Kinetics ◽  
Pure Water ◽  
Squamous Carcinoma ◽  
Peak Shift ◽  
Intensity Increase ◽  
Nude Mouse Model ◽  
Absorption And Emission ◽  
Squamous Carcinoma Cells

Background: Nanoparticle imaging and tracking the release of the loaded material from the nanoparticle system have attracted significant attention in recent years. If the release of the loaded molecules could be monitored reliably in vivo, it would speed up the development of drug delivery systems remarkably. Methods: Here, we test a system that uses indocyanine green (ICG) as a fluorescent agent for studying release kinetics in vitro and in vivo from the lipid iron nanoparticle delivery system. The ICG spectral properties like its concentration dependence, sensitivity and the fluctuation of the absorption and emission wavelengths can be utilized for gathering information about the change of the ICG surrounding. Results: We have found that the absorption, fluorescence, and photoacoustic spectra of ICG in lipid iron nanoparticles differ from the spectra of ICG in pure water and plasma. We followed the ICG containing liposomal nanoparticle uptake into squamous carcinoma cells (SCC) by fluorescence microscopy and the in vivo uptake into SCC tumors in an orthotopic xenograft nude mouse model under a surgical microscope. Conclusion: Absorption and emission properties of ICG in the different solvent environment, like in plasma and human serum albumin, differ from those in aqueous solution. Photoacoustic spectral imaging confirmed a peak shift towards longer wavelengths and an intensity increase of ICG when bound to the lipids. The SCC cells showed that the ICG containing liposomes bind to the cell surface but are not internalized in the SCC-9 cells after 60 minutes of incubation. We also showed here that ICG containing liposomal nanoparticles can be traced under a surgical camera in vivo in orthotopic SCC xenografts in mice.

scholarly journals The inhibitory effect of silencing CDCA3 on migration and proliferation in bladder urothelial carcinoma

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dexin Shen ◽  
Yayun Fang ◽  
Fenfang Zhou ◽  
Zhao Deng ◽  
Kaiyu Qian ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Urothelial Carcinoma ◽  
Carcinoma Cells ◽  
Expression Level ◽  
Tumor Cell Growth ◽  
Migration Ability ◽  
Bladder Urothelial Carcinoma ◽  
Related Proteins

Abstract Background CDCA3 is an important component of the E3 ligase complex with SKP1 and CUL1, which could regulate the progress of cell mitosis. CDCA3 has been widely identified as a proto-oncogene in multiple human cancers, however, its role in promoting human bladder urothelial carcinoma has not been fully elucidated. Methods Bioinformatic methods were used to analyze the expression level of CDCA3 in human bladder urothelial carcinoma tissues and the relationship between its expression level and key clinical characteristics. In vitro studies were performed to validate the specific functions of CDCA3 in regulating cell proliferation, cell migration and cell cycle process. Alterations of related proteins was investigated by western blot assays. In vivo studies were constructed to validate whether silencing CDCA3 could inhibit the proliferation rate in mice model. Results Bioinformatic analysis revealed that CDCA3 was significantly up-regulated in bladder urothelial carcinoma samples and was related to key clinical characteristics, such as tumor grade and metastasis. Moreover, patients who had higher expression level of CDCA3 tend to show a shorter life span. In vitro studies revealed that silencing CDCA3 could impair the migration ability of tumor cells via down-regulating EMT-related proteins such as MMP9 and Vimentin and inhibit tumor cell growth via arresting cells in the G1 cell cycle phase through regulating cell cycle related proteins like p21. In vivo study confirmed that silencing CDCA3 could inhibit the proliferation of bladder urothelial carcinoma cells. Conclusions CDCA3 is an important oncogene that could strengthen the migration ability of bladder urothelial carcinoma cells and accelerate tumor cell growth via regulating cell cycle progress and is a potential biomarker of bladder urothelial carcinoma.

In vitro cytotoxic data on Se-methylselenocysteine conjugated to dendritic poly(glycerol) against human squamous carcinoma cells

2021 ◽  
pp. 1-12
Author(s):  
Nicoli Dolores Gonçalves Correa ◽  
Felipe Douglas Silva ◽  
Daniel Perez Vieira ◽  
Carlos Rogerio Soares ◽  
Alvaro Antonio Alencar de Queiroz
Keyword(s):  
Squamous Carcinoma ◽  
Carcinoma Cells ◽  
Squamous Carcinoma Cells
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