In this paper the analysis is conducted to investigate the progressive collapse resistance of typical reinforced concrete(RC) multi-story frame structures, which are designed according to the China code for seismic design of buildings. The analysis results show that the progressive collapse resistance will be enhanced with the seismic fortification intensity increasing. The progressive collapse resistance of RC frame structures with low seismic fortification intensity are poor. This implies that as for RC frame structures with low seismic or non-seismic demand, close attention must be paid to continuity and ductility in order to prevent progressive collapse.