Long-term repeatability of cartilage oligomeric matrix protein kinetics in response to walking stress

2021 ◽  
Vol 29 ◽  
pp. S150-S152
Author(s):  
S. Herger ◽  
A.-M. Liphardt ◽  
C. Egloff ◽  
N. Corina ◽  
A. Mündermann
Keyword(s):  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Protein Kinetics

Can Tocilizumab Decrease Cartilage Oligomeric Matrix Protein Levels and Disease Activity in Patients with Long-Standing Rheumatoid Arthritis?

2015 ◽  
Vol 11 (999) ◽  
pp. 1-1
Author(s):  
Maurizio Benucci ◽  
Francesca Meacci ◽  
Mariangela Manfredi ◽  
Francesca Gobbi ◽  
Maria Infantino ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Protein Levels

Clinical impact of myositis-specific autoantibodies on long-term prognosis of juvenile idiopathic inflammatory myopathies: multicentre study

Rheumatology ◽  
2021 ◽  
Author(s):  
Yuichi Yamasaki ◽  
Norimoto Kobayashi ◽  
Shinji Akioka ◽  
Kazuko Yamazaki ◽  
Shunichiro Takezaki ◽  
...  
Keyword(s):  
Matrix Protein ◽  
Multiple Drug ◽  
Idiopathic Inflammatory Myopathies ◽  
Inflammatory Myopathies ◽  
Gamma Subunits ◽  
Specific Autoantibody ◽  
Long Term Prognosis ◽  
Using Data ◽  
Drug Free

Abstract Objectives This study aimed to investigate the clinical characteristics, treatment and prognosis of juvenile idiopathic inflammatory myopathies (JIIM) in Japan for each myositis-specific autoantibody (MSA) profile. Methods A multicentre, retrospective study was conducted using data of patients with JIIM at nine paediatric rheumatology centres in Japan. Patients with MSA profiles, determined by immunoprecipitation using stored serum from the active stage, were included. Results MSA were detected in 85 of 96 cases eligible for the analyses. Over 90% of the patients in this study had one of the following three MSA types: anti-melanoma differentiation-associated protein 5 (MDA5) (n = 31), anti-transcriptional intermediary factor 1 alpha and/or gamma subunits (TIF1γ) (n = 25) and anti-nuclear matrix protein 2 (NXP2) (n = 25) antibodies. Gottron papules and periungual capillary abnormalities were the most common signs of every MSA group in the initial phase. The presence of interstitial lung disease (ILD) was the highest risk factor for patients with anti-MDA5 antibodies. Most patients were administered multiple drug therapies: glucocorticoids and MTX were administered to patients with anti-TIF1γ or anti-NXP2 antibodies. Half of the patients with anti-MDA5 antibodies received more than three medications including i.v. CYC, especially patients with ILD. Patients with anti-MDA5 antibodies were more likely to achieve drug-free remission (29 vs 21%) and less likely to relapse (26 vs 44%) than others. Conclusion Anti-MDA5 antibodies are the most common MSA type in Japan, and patients with this antibody are characterized by ILD at onset, multiple medications including i.v. CYC, drug-free remission, and a lower frequency of relapse. New therapeutic strategies are required for other MSA types.

scholarly journals Analysis of Cartilage Oligomeric Matrix Protein (COMP) in Synovial Fluid, Serum and Urine from 51 Racehorses with Carpal Bone Fracture

2008 ◽  
Vol 70 (9) ◽  
pp. 915-921 ◽  
Author(s):  
Koh ARAI ◽  
Masaaki TAGAMI ◽  
Takashi HATAZOE ◽  
Eikoh NISHIMATSU ◽  
Yuri SHIMIZU ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Bone Fracture ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Carpal Bone ◽  
Serum And Urine

scholarly journals Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury

Cell Research ◽  
2021 ◽  
Author(s):  
Yi Fu ◽  
Yaqian Huang ◽  
Zhao Yang ◽  
Yufei Chen ◽  
Jingang Zheng ◽  
...  
Keyword(s):  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Therapeutic Strategies ◽  
At1 Receptor ◽  
Extracellular Matrix Protein ◽  
Binding Motif ◽  
Abdominal Aortic ◽  
Novel Therapeutic Strategies ◽  
G Protein Coupled

AbstractCompelling evidence has revealed that biased activation of G protein-coupled receptor (GPCR) signaling, including angiotensin II (AngII) receptor type 1 (AT1) signaling, plays pivotal roles in vascular homeostasis and injury, but whether a clinically relevant endogenous biased antagonism of AT1 signaling exists under physiological and pathophysiological conditions has not been clearly elucidated. Here, we show that an extracellular matrix protein, cartilage oligomeric matrix protein (COMP), acts as an endogenous allosteric biased modulator of the AT1 receptor and its deficiency is clinically associated with abdominal aortic aneurysm (AAA) development. COMP directly interacts with the extracellular N-terminus of the AT1 via its EGF domain and inhibits AT1-β-arrestin-2 signaling, but not Gq or Gi signaling, in a selective manner through allosteric regulation of AT1 intracellular conformational states. COMP deficiency results in activation of AT1a-β-arrestin-2 signaling and subsequent exclusive AAA formation in response to AngII infusion. AAAs in COMP–/– or ApoE–/– mice are rescued by AT1a or β-arrestin-2 deficiency, or the application of a peptidomimetic mimicking the AT1-binding motif of COMP. Explorations of the endogenous biased antagonism of AT1 receptor or other GPCRs may reveal novel therapeutic strategies for cardiovascular diseases.

scholarly journals Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin

2008 ◽  
Vol 16 (11) ◽  
pp. 1413-1420 ◽  
Author(s):  
Y. Luan ◽  
L. Kong ◽  
D.R. Howell ◽  
K. Ilalov ◽  
M. Fajardo ◽  
...  
Keyword(s):  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein

High specificity but low sensitivity of the cartilage oligomeric matrix protein (COMP) test in rheumatoid arthritis and osteoarthritis

2010 ◽  
Vol 48 (4) ◽  
Author(s):  
Ana Lígia Bender ◽  
Inês Guimaraes da Silveira ◽  
Carlos Alberto von Mühlen ◽  
Henrique Luiz Staub
Keyword(s):  
Rheumatoid Arthritis ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
High Specificity ◽  
Low Sensitivity

scholarly journals Serum cartilage oligomeric matrix protein reflects the presence of clinically diagnosed synovitis in patients with knee osteoarthritis

2001 ◽  
Vol 9 (7) ◽  
pp. 612-618 ◽  
Author(s):  
V. Vilı́m ◽  
R. Vytášek ◽  
M. Olejárová ◽  
S. Macháček ◽  
J. Gatterová ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein

scholarly journals 91 SERUM CARTILAGE OLIGOMERIC MATRIX PROTEIN (COMP) AND HAND OSTEOARTHRITIS (HOA)

2008 ◽  
Vol 16 ◽  
pp. S53-S54
Author(s):  
M. Scarpellini ◽  
A. Lurati ◽  
K. Re ◽  
M. Marrazza
Keyword(s):  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Hand Osteoarthritis

scholarly journals Post-translational Modifications in Cartilage Oligomeric Matrix Protein

1997 ◽  
Vol 272 (22) ◽  
pp. 14120-14126 ◽  
Author(s):  
Joseph Zaia ◽  
Raymond E. Boynton ◽  
Angela McIntosh ◽  
Daniel R. Marshak ◽  
Henric Olsson ◽  
...  
Keyword(s):  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Post Translational Modifications
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