Protonated water-soluble N-heterocyclic carbene ruthenium(II) complexes: Synthesis, cytotoxic and DNA binding properties and molecular docking study

2018 ◽  
Vol 869 ◽  
pp. 67-74 ◽  
Author(s):  
Mitat Akkoç ◽  
Sevgi Balcıoğlu ◽  
Canbolat Gürses ◽  
Tugba Taskin Tok ◽  
Burhan Ateş ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Dna Binding ◽  
Docking Study ◽  
Water Soluble ◽  
Molecular Docking Study ◽  
Binding Properties ◽  
Dna Binding Properties

DNA-Binding Properties and Photocleavage Activity of Cationic Water-Soluble Chlorophyll Derivatives

2006 ◽  
Vol 12 (24) ◽  
pp. 6331-6340 ◽  
Author(s):  
Hidetoshi Taima ◽  
Akihiro Okubo ◽  
Naoki Yoshioka ◽  
Hidenari Inoue
Keyword(s):  
Dna Binding ◽  
Water Soluble ◽  
Binding Properties ◽  
Dna Binding Properties ◽  
Chlorophyll Derivatives

Synthesis, Antiproliferative and Cytotoxic Activities, DNA Binding Features and Molecular Docking Study of Novel Enamine Derivatives

2020 ◽  
Vol 17 (7) ◽  
Author(s):  
Meliha Burcu Gürdere ◽  
Ali Aydin ◽  
Belkız Yencilek ◽  
Fatih Ertürk ◽  
Oğuz Özbek ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Dna Binding ◽  
Docking Study ◽  
Cytotoxic Activities ◽  
Molecular Docking Study

scholarly journals Synthesis, Computational studies, DNA-binding and cytotoxicity of 4-Thiazolidonone-cyclopropyl hybrid

2021 ◽  
Author(s):  
MD MUSHTAQUE ◽  
Fernando Avecilla ◽  
Mariyam Jahan ◽  
Irfan Ahmad ◽  
Mohd Saeed ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Dna Binding ◽  
Computational Study ◽  
Docking Study ◽  
Moderate Activity ◽  
Binding Studies ◽  
Molecular Docking Study ◽  
Spectral Techniques ◽  
Ct Dna

Abstract A derivative of 4-Thiazolidinone derivative endowing cyclopropyl ring substituted at 3-nitrogen positioned was synthesized that was further evaluated against cancerous cell lines MCF-7. The structure of synthesized compound (6) was well characterized by different spectral techniques such as FT-IR, UV-Visible, 1H-NMR, 13C-NMR and mass spectrophotometer. X-ray single crystal structure and Computational study (DFT) study revealed that compound (6) adopted (2Z, 5Z)-configuration. Preliminary In vitro study suggested that compound (6) displayed moderate activity bearing IC50(161.0 μM). The DNA binding studies (Ct-DNA) with compound (6) was performed. The study suggested that bound with DNA exhibiting binding constant Kb = 3.3 x 104 LMol-1). Furthermore, the binding study was complemented by Molecular docking possessingDNA binding studies (Ct-DNA) were performed. Final compound (6) exhibited moderate cytotoxicity effect (IC50 = 161.0 μM) and DNA binding ability (Kb = 3.3 x 104 LMol-1). The experimental findings were completed by molecular docking study.

scholarly journals DNA binding properties, histidine interaction and cytotoxicity studies of water soluble ruthenium(ii) terpyridine complexes

2016 ◽  
Vol 45 (11) ◽  
pp. 4633-4646 ◽  
Author(s):  
Dejan Lazić ◽  
Aleksandar Arsenijević ◽  
Ralph Puchta ◽  
Živadin D. Bugarčić ◽  
Ana Rilak
Keyword(s):  
Dna Binding ◽  
Competitive Binding ◽  
Water Soluble ◽  
Binding Studies ◽  
Binding Properties ◽  
Cytotoxicity Studies ◽  
Vis Spectroscopy ◽  
Spectroscopy Studies ◽  
Ct Dna ◽  
Dna Binding Properties

UV-Vis spectroscopy studies, viscosity measurements and competitive binding studies with EB have revealed the ability of the complexes to bind to CT DNA covalently through N7 of guanine residues and non-covalently through intercalation.

DNA Binding, amelioration of oxidative stress, and molecular docking study of Zn(II) metal complex of a new Schiff base ligand

2018 ◽  
Vol 71 (14) ◽  
pp. 2165-2182 ◽  
Author(s):  
Dipu Kumar Mishra ◽  
Uttam Kumar Singha ◽  
Ananya Das ◽  
Somit Dutta ◽  
Pallab Kar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Schiff Base ◽  
Molecular Docking ◽  
Dna Binding ◽  
Metal Complex ◽  
Schiff Base Ligand ◽  
Docking Study ◽  
Molecular Docking Study
Sign in / Sign up

Export Citation Format

Share Document