<p>7-methylguanosine, the so-called mRNA cap 0 bears a very labile C8-H
bond, due to the formation of an ylide/N-heterocyclic carbene, upon proton
loss. The reaction of 7-methylguanosine
with Pt(PPh3)4, via C-H
oxidative addition, yields a hydrido–PtII carbene complex and this reactivity
can be extrapolated to 7,9-dimethylguanine. </p>
Room temperature reaction of the uranium(IV)-carbene [U{C(SiMe3)(PPh2)}(BIPMTMS)(μ-Cl)Li(TMEDA)(μ-TMEDA)0.5]2 (1, BIPMTMS = C(PPh2NSiMe3)2) with white phosphorus (P4) produces the organo-P5 compound [P5{C(SiMe3)(PPh2)}2][Li(TMEDA)2] (2) and the uranium(IV)-methanediide [U{BIPMTMS}{Cl}{μ-Cl}2{Li(TMEDA)}] (3). This is an unprecedented...
The ruthenium carbene pincer complex 2 was synthesized treating the benzo annulated cycloheptatriene bisphosphine 1 with RuCl3. Addition of three equivalents of hydrogen to the carbocyclic carbene complex 2 was...
An atom- and step-economic intermolecular multi-component palladium-catalyzed C–H amidation of alkenes with carbon monoxide and organic azides has been developed for the synthesis of alkenyl amides. The reaction proceeds efficiently without an ortho-directing group on the alkene substrates. Nontoxic dinitrogen is generated as the sole by-product. Computational studies and control experiments have revealed that the reaction takes place via an unexpected mechanism by tandem palladium catalysis.