On the Reactivity of mRNA Caps: C-H Oxidative Addition of 7-Methylguanosine to Pt(0)
<p>7-methylguanosine, the so-called mRNA cap 0 bears a very labile C8-H bond, due to the formation of an ylide/N-heterocyclic carbene, upon proton loss. The reaction of 7-methylguanosine with Pt(PPh3)4, via C-H oxidative addition, yields a hydrido–PtII carbene complex and this reactivity can be extrapolated to 7,9-dimethylguanine. </p>
2003 ◽
Vol 125
(33)
◽
pp. 10066-10073
◽
2019 ◽
Keyword(s):
Keyword(s):
2007 ◽
Vol 360
(8)
◽
pp. 2661-2668
◽