Intermolecular C–H Amidation of Alkenes with Carbon Monoxide and Azides via Tandem Palladium Catalysis
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An atom- and step-economic intermolecular multi-component palladium-catalyzed C–H amidation of alkenes with carbon monoxide and organic azides has been developed for the synthesis of alkenyl amides. The reaction proceeds efficiently without an ortho-directing group on the alkene substrates. Nontoxic dinitrogen is generated as the sole by-product. Computational studies and control experiments have revealed that the reaction takes place via an unexpected mechanism by tandem palladium catalysis.
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2020 ◽
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2013 ◽
Vol 33
(3)
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pp. 523-529
1991 ◽
Vol 56
(3)
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pp. 663-672
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2018 ◽
Vol 83
(15)
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pp. 7860-7866
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