Comment on Miki et al.: Randomized open-label non-inferiority trial of acetaminophen or loxoprofen for patients with acute low back pain

2019 ◽  
Vol 24 (1) ◽  
pp. 189
Author(s):  
Katsuhiro Toda
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Low Back ◽  
Open Label ◽  
Acute Low Back Pain

Effectiveness of Tolperisone Hydrochloride with Aceclofenac as Combined Therapy in Acute Low Back Pain.

2012 ◽  
Vol 23 (2) ◽  
pp. 74-78 ◽  
Author(s):  
B Bhattacharjya ◽  
S Mohammad Naser ◽  
A Biswas ◽  
F Kamal ◽  
K Banerjee
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Adverse Effects ◽  
Combined Therapy ◽  
Low Back ◽  
Open Label ◽  
Total N ◽  
Treatment Groups ◽  
Acute Low Back Pain ◽  
Categorical Scale

Abstract Objective An open label, non-randomised, prospective study was conducted to evaluate the effectiveness of tolperisone hydrochloride 150mg thrice daily with aceclofenac 100mg twice daily compared to aceclofenac 100mg twice daily alone for the treatment of acute low back pain (LBP) for 14 days. total (n=242) patients recruited for the study were divided into two treatment groups. One of the group (n=124) received oral tolperisone plus aceclofenac and the other (n=118) Aceclofenac alone. The pain intensity was assessed by visual analogue scale. Patients were informed to report any adverse effect encountered during the study period. The overall effect of the drug (global assessment of the study medication) on pain and adverse effects were assessed by the patients at the end of the trial on a categorical scale. There was significant reduction in pain score in the tolperisone group than aceclofenac group with insignificant adverse effects which didn't require discontinuation of the study. Tolperisone when added with aceclofenac can be more effective than aceclofenac alone for relief of acute LBP with minimum adverse effects.

scholarly journals A comparative study on safety and efficacy of tolperisone with etodolac and thiocolchicoside with etodolac in patients of acute low back pain with musculoskeletal spasm

2019 ◽  
Vol 8 (11) ◽  
pp. 2459
Author(s):  
Tanu Garg ◽  
Vijay K. Yadav
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Side Effects ◽  
Low Back ◽  
Open Label ◽  
Open Label Study ◽  
Acute Low Back Pain ◽  
Group A ◽  
Group B

Background: Low back pain is one of the most common health problems in society which leads to considerable disability, loss of work days, and puts a huge burden on socioeconomic and healthcare system. It is often associated with musculoskeletal spasm. The aim of the study was to compare the efficacy and safety of tolperisone and thiocolchicoside in combination with etodolac in patients of acute low back pain associated with musculoskeletal spasm.Methods: it was a prospective, randomized, open label study which included patients of either sex between age 18-50 years of acute low back pain with musculoskeletal spasm. Patients were allocated in two groups. Patients in ‘Group A’ were given tolperisone 150 mg + etodolac 400 mg twice a day and patients in ‘Group B’ were given thiocolchicoside 4 mg + etodolac 400 mg twice a day. Efficacy of two drugs was assessed by decrease in finger to floor distance (FFD), decrease in pain as per visual analog scale (VAS) and global assessment of efficacy of treatment by physician. Follow-up of the patients was done on day 3 and 7 of treatment. Various side effects reported by patients in both the groups were also recorded and compared.Results: Both tolperisone and thiocolchicoside caused significant decrease in FFD, reduced pain score thus indicating decrease in pain and spasm. Side effects reported in both groups were mild and did not result in discontinuation of therapy.Conclusions: Tolperisone was found to have efficacy similar to that of thiocolchicoside though number of side effects reported was more with tolperisone.

Low Back Pain in Commercial Airline Pilots

2020 ◽  
Vol 91 (12) ◽  
pp. 940-947
Author(s):  
Matthias Albermann ◽  
Maria Lehmann ◽  
Christian Eiche ◽  
Joachim Schmidt ◽  
Johannes Prottengeier
Keyword(s):  
Risk Factors ◽  
Low Back Pain ◽  
Back Pain ◽  
Online Survey ◽  
German Population ◽  
Low Back ◽  
Airline Pilots ◽  
Acute Low Back Pain ◽  
Commercial Airline ◽  
Negative Effect

BACKGROUND: In their working life, airline pilots are exposed to particular risk factors that promote nonspecific low back pain (LBP). Because of the varying incidence internationally, we evaluated the point prevalences of acute, subacute, and chronic nonspecific LBP, as well as the current prevalences in German airline pilots. Furthermore, we compared the prevalence to the general German population and to European counterparts.METHODS: An anonymous online survey of 698 participating German airline pilots was evaluated. The impairment between groups was analyzed. Prevalences from our data were compared to existing data.RESULTS: The following point prevalences were found: 8.2% acute, 2.4% subacute, 82.7% chronic LBP; 74.1% of all individuals were suffering from current LBP when answered the questionnaire. A total time spent flying greater than 600 h within the last 12 mo was significantly related to acute nonspecific LBP. Individuals with any type of LBP were significantly impaired compared to those unaffected. It was found that German airline pilots suffer more often from current LBP than the general population and have a higher point prevalence of total LBP than their European counterparts.CONCLUSIONS: The evaluation showed a surprisingly high, previously unidentified, prevalence of nonspecific LBP in German airline pilots. Why German airline pilots suffer more often from LBP remains uncertain. The number of flying hours appears to have a negative effect on developing acute low back pain, but causation cannot be concluded. Other risk factors could not be confirmed.Albermann M, Lehmann M, Eiche C, Schmidt J, Prottengeier J. Low back pain in commercial airline pilots. Aerosp Med Hum Perform. 2020; 91(12):940947.

Sign in / Sign up

Export Citation Format

Share Document