Iatrogenic nerve lesions are frequently neglected. The chapter stresses the importance of adequate assessment, surgical timing, surgical strategies, follow-up, and results. Using the example of a radial nerve lesion in discontinuity due to osteosynthesis after humeral fracture, the authors describe a typical patient history with delayed presentation, as well as the role of physical examination, electrophysiology, and high-resolution ultrasound in demonstrating substantial nerve damage incompatible with spontaneous recovery. Surgical findings are demonstrated, along with a stepwise approach for nerve reconstruction via sural nerve graft. Clinical approach and surgery for traumatic radial nerve lesions are detailed, as well as general information on iatrogenic nerve lesions.