Hype or hope of hyaluronic acid for osteoarthritis: Integrated clinical evidence synthesis with multi-organ transcriptomics

Abstract Study Objective: Evidence syntheses perform rigorous investigations of the primary literature and they have played a vital role in generating evidence-based recommendations for governments worldwide during the COVID-19 pandemic. However, there has not yet been an attempt to organize them across topic and other characteristics. This study performed a systematic mapping exercise of non-clinical evidence syntheses pertaining to COVID-19. Methods: This study conducted a systematic search on December 5, 2020 across 10 databases and servers: CINAHL, Embase, Global Health, Healthstar, MEDLINE, PsychINFO, and Web of Science, Research Square, MEDRxiv, and PROSPERO. Only full evidence syntheses published in a peer-reviewed journal or preprint server were included. Results: This study classified all evidence synthesis in the following topics: health service delivery (n = 280), prevention and behavior (n = 201), mental health (n = 140), social epidemiology (n = 31), economy (n = 22), and environment (n = 19). This study provides a comprehensive resource of all evidence syntheses categorized according to topic. Conclusions: This study proposes the following research priorities: governance, the impact of COVID-19 on different populations, the effectiveness of prevention and control methods across contexts, mental health, and vaccine hesitancy.

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Injectable Systems for Intra-Articular Delivery of Mesenchymal Stromal Cells for Cartilage Treatment: A Systematic Review of Preclinical and Clinical Evidence

International Journal of Molecular Sciences ◽

10.3390/ijms19113322 ◽

2018 ◽

Vol 19 (11) ◽

pp. 3322 ◽

Cited By ~ 7

Author(s):

Alice Roffi ◽

Norimasa Nakamura ◽

Mikel Sanchez ◽

Magali Cucchiarini ◽

Giuseppe Filardo

Keyword(s):

Systematic Review ◽

Hyaluronic Acid ◽

Clinical Evidence ◽

Platelet Rich Plasma ◽

Cell Manipulation ◽

Cartilage Lesions ◽

Cell Based Therapy ◽

Clinical Literature ◽

Clinical Benefits ◽

Cell Dissemination

Stem cell-based therapy is a promising approach to treat cartilage lesions and clinical benefits have been reported in a number of studies. However, the efficacy of cell injection procedures may be impaired by cell manipulation and damage as well as by cell dissemination to non-target tissues. To overcome such issues, mesenchymal stromal cell (MSC) delivery may be performed using injectable vehicles as containment systems that further provide a favorable cell microenvironment. The aim of this systematic review was to analyze the preclinical and clinical literature on platelet-rich plasma (PRP), hyaluronic acid (HA), and hydrogels for the delivery of MSCs. The systematic literature search was performed using the PubMed and Web of science databases with the following string: “(stem cells injection) AND (platelet rich plasma OR PRP OR platelet concentrate OR biomaterials OR hyaluronic acid OR hydrogels)”: 40 studies (19 preclinical and 21 clinical) met the inclusion criteria. This review revealed an increasing interest on the use of injectable agents for MSC delivery. However, while negligible adverse events and promising clinical outcomes were generally reported, the prevalence of low quality studies hinders the possibility to demonstrate the real benefits of using such injectable systems. Specific studies must be designed to clearly demonstrate the added benefits of these systems to deliver MSCs for the treatment of cartilage lesions and osteoarthritis.

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Efficacy of Percutaneous Intraarterial Facial/Supratrochlear Arterial Hyaluronidase Injection for Treatment of Vascular Embolism Resulting From Hyaluronic Acid Filler Cosmetic Injection

Aesthetic Surgery Journal ◽

10.1093/asj/sjab425 ◽

2021 ◽

Author(s):

Can Zheng ◽

Qiang Fu ◽

Gui-wen Zhou ◽

Lin-ying Lai ◽

Li-xia Zhang ◽

...

Keyword(s):

Hyaluronic Acid ◽

Visual Impairment ◽

Skin Necrosis ◽

Clinical Evidence ◽

Symptomatic Treatment ◽

Nutritional Therapy ◽

Facial Artery ◽

Facial Skin ◽

Filler Injection ◽

Rescue Treatment

Abstract Background Vascular embolism is a serious complication of hyaluronic acid (HA) filler cosmetic injection and hyaluronidase injection has been proposed as the treatment. Until now there is a lack of adequate clinical evidence regarding the benefits of treatment for HA filler-induced vascular embolism by percutaneous facial or supratrochlear arterial hyaluronidase injection. Objectives To evaluate the efficacy of percutaneous facial or supratrochlear arterial hyaluronidase injection as a rescue treatment for HA filler-induced vascular embolism. Methods We included 17 patients with vascular embolism after facial HA filler injection. Intraarterial injection of 1500 units hyaluronidase was performed via facial artery for thirteen cases with skin necrosis and via supratrochlear arterial for four cases with severe ptosis and skin necrosis but no visual impairment. Simultaneously, the general symptomatic treatment and nutritional therapy were performed. Results After hyaluronidase injection, the facial skin necrosis in all cases was restored and the ptosis in the four cases was also significantly relieved. Patients were subsequently followed for 1 month to 1 year. The skin necrosis in 16 patients were completely healed and only 1 patient had small, superficial scars. Conclusions It is effective to alleviate the skin necrosis and ptosis resulting from HA filler embolism via percutaneous facial or supratrochlear arterial hyaluronidase injection.

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