Simultaneous determination of p-aminobenzoic acid and its metabolites in the urine of volunteers, treated with p-aminobenzoic acid sunscreen formulation

2007 ◽  
Vol 43 (4) ◽  
pp. 1430-1436 ◽  
Author(s):  
Lai-Hao Wang ◽  
Wen-Shiuan Huang ◽  
Huo-Mu Tai
Keyword(s):  
Simultaneous Determination ◽  
Aminobenzoic Acid ◽  
Sunscreen Formulation

Simultaneous determination of procaine and para-aminobenzoic acid by LC–MS/MS method

2007 ◽  
Vol 847 (2) ◽  
pp. 224-230 ◽  
Author(s):  
Mugunthu R. Dhananjeyan ◽  
Crystal Bykowski ◽  
Jill A. Trendel ◽  
Jeffrey G. Sarver ◽  
Howard Ando ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Aminobenzoic Acid

Simultaneous Determination of Octinoxate, Oxybenzone, and Octocrylene in a Sunscreen Formulation Using Validated Spectrophotometric and Chemometric Methods

2015 ◽  
Vol 98 (5) ◽  
pp. 1215-1225 ◽  
Author(s):  
Maha F Abdel-Ghany ◽  
Omar Abdel-Aziz ◽  
Miriam F Ayad ◽  
Neven N Mikawy
Keyword(s):  
Least Squares ◽  
Simultaneous Determination ◽  
Partial Least Squares ◽  
Uv Filters ◽  
Chemometric Methods ◽  
Zero Crossing ◽  
Accuracy And Precision ◽  
Mean Centering ◽  
Sunscreen Formulation

Abstract Accurate, reliable, and sensitive spectrophotometric and chemometric methods were developed for simultaneous determination of octinoxate (OMC), oxybenzone (OXY), and octocrylene (OCR) in a sunscreen formulation without prior separation steps, including derivative ratio spectra zero crossing (DRSZ), double divisor ratio spectra derivative (DDRD), mean centering ratio spectra (MCR), and partial least squares (PLS-2). With the DRSZ technique, the UV filters could be determined in the ranges of 0.5–13.0, 0.3–9.0, and 0.5–9.0 μg/mL at 265.2, 246.6, and 261.8 nm, respectively. By utilizing the DDRD technique, UV filters could be determined in the above ranges at 237.8, 241.0, and 254.2 nm, respectively. With the MCR technique, the UV filters could be determined in the above ranges at 381.7, 383.2, and 355.6 nm, respectively. The PLS-2 technique successfully quantified the examined UV filters in the ranges of 0.5–9.3, 0.3–7.1, and 0.5–6.9 μg/mL, respectively. All the methods were validated according to the International Conference on Harmonization guidelines and successfully applied to determine the UV filters in pure form, laboratory-prepared mixtures, and a sunscreen formulation. The obtained results were statistically compared with reference and reported methods of analysis for OXY, OMC, and OCR, and there were no significant differences with respect to accuracy and precision of the adopted techniques.

Validated simultaneous determination of antipyrine and benzocaine HCl in the presence of benzocaine HCl degradation product

2014 ◽  
Vol 6 (15) ◽  
pp. 6044-6050 ◽  
Author(s):  
Hanan A. Merey ◽  
Hala E. Zaazaa
Keyword(s):  
Quantitative Determination ◽  
Simultaneous Determination ◽  
Degradation Product ◽  
Aminobenzoic Acid ◽  
Stability Indicating

Two validated, sensitive and highly selective stability-indicating methods were adopted for the simultaneous quantitative determination of antipyrine (ANT) and benzocaine HCl (BEN) in the presence of the degradation product of benzocaine HCl [p-aminobenzoic acid (PABA)].

Rapid and sensitive HPLC assay for simultaneous determination of procaine and para-aminobenzoic acid from human and rat liver tissue extracts

2008 ◽  
Vol 867 (2) ◽  
pp. 247-252 ◽  
Author(s):  
Mugunthu R. Dhananjeyan ◽  
Jill A. Trendel ◽  
Crystal Bykowski ◽  
Jeffrey G. Sarver ◽  
Howard Ando ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Rat Liver ◽  
Liver Tissue ◽  
Hplc Assay ◽  
Aminobenzoic Acid ◽  
Tissue Extracts

A general computer program for the extended plate overlap algorithm

1978 ◽  
Vol 48 ◽  
pp. 287-293 ◽  
Author(s):  
Chr. de Vegt ◽  
E. Ebner ◽  
K. von der Heide
Keyword(s):  
Computer Program ◽  
Simultaneous Determination ◽  
General Computer Program ◽  
General Computer

In contrast to the adjustment of single plates a block adjustment is a simultaneous determination of all unknowns associated with many overlapping plates (star positions and plate constants etc. ) by one large adjustment. This plate overlap technique was introduced by Eichhorn and reviewed by Googe et. al. The author now has developed a set of computer programmes which allows the adjustment of any set of contemporaneous overlapping plates. There is in principle no limit for the number of plates, the number of stars, the number of individual plate constants for each plate, and for the overlapping factor.

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