Development and validation of an ultrafast chromatographic method for quantification of the immunosuppressant mycophenolic acid in canine, feline and human plasma

2016 ◽  
Vol 131 ◽  
pp. 94-102 ◽  
Author(s):  
Sol-Maiam Rivera Vélez ◽  
Alice Morassi ◽  
Michael H. Court ◽  
Jennifer E. Slovak ◽  
Nicolas F. Villarino
Keyword(s):  
Human Plasma ◽  
Mycophenolic Acid ◽  
Chromatographic Method ◽  
Development And Validation

scholarly journals Development and validation of a chromatographic method for quantification of rasagiline in human plasma

2019 ◽  
Vol 17 (11) ◽  
pp. 2243 ◽  
Author(s):  
Rabiea Bilal ◽  
Muhammad Usman ◽  
Abdul Muqeet Khan ◽  
Waqas Latif ◽  
Naseem Saud Ahmad ◽  
...  
Keyword(s):  
Human Plasma ◽  
Chromatographic Method ◽  
Development And Validation

scholarly journals Development and Validation of a High-Performance Liquid Chromatographic Method for the Determination of Cinitapride in Human Plasma

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Boovizhikannan Thangabalan ◽  
Getu Kahsay ◽  
Tadele Eticha
Keyword(s):  
Human Plasma ◽  
High Performance ◽  
Chromatographic Method ◽  
High Performance Liquid Chromatographic ◽  
Reversed Phase ◽  
Liquid Chromatographic Method ◽  
Us Fda ◽  
Development And Validation ◽  
Liquid Chromatographic

A precise and reliable reversed-phase high-performance liquid chromatographic method with ultraviolet detection was developed and validated to determine cinitapride in human plasma. After liquid-liquid extraction, chromatographic separation was achieved on a Nucleosil C18 (25 cm × 4.6 mm, 5 µm) column with an isocratic elution consisting of 10 mM ammonium acetate (pH 5.2), methanol, and acetonitrile, 40 : 50 : 10, v/v/v. The developed method was validated as per US FDA guidelines for its linearity, selectivity, sensitivity, precision, accuracy, and stability. Satisfactory findings were obtained from the validation studies. The linearity range of the method was 1 to 35 ng/mL while the extraction recovery of cinitapride in human plasma was more than 86%. The percent coefficient of variation of both intraday and interday precision was ≤7.1%.

Development and Validation of a Liquid Chromatographic Method for Determination of Efavirenz in Human Plasma

2007 ◽  
Vol 65 (5-6) ◽  
pp. 359-361 ◽  
Author(s):  
A. Lakshmi Sailaja ◽  
K. Kishore Kumar ◽  
D. V. R. Ravi Kumar ◽  
C. Mohan Kumar ◽  
N. M. Yugandhar ◽  
...  
Keyword(s):  
Human Plasma ◽  
Chromatographic Method ◽  
Liquid Chromatographic Method ◽  
Development And Validation ◽  
Liquid Chromatographic
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