PLGA Ethionamide Nanoparticles for Pulmonary Delivery: Development and in vivo evaluation of dry powder inhaler

2017 ◽  
Vol 145 ◽  
pp. 854-859 ◽  
Author(s):  
Sujit Kumar Debnath ◽  
Srinivasan Saisivam ◽  
Abdelwahab Omri
Keyword(s):  
Dry Powder Inhaler ◽  
Pulmonary Delivery ◽  
Dry Powder ◽  
In Vivo Evaluation

scholarly journals Preparation and Characterization of a Dry Powder Inhaler Composed of PLGA Large Porous Particles Encapsulating Gentamicin Sulfate

2019 ◽  
Vol 9 (2) ◽  
pp. 255-261 ◽  
Author(s):  
Farideh Shiehzadeh ◽  
Mohsen Tafaghodi ◽  
Majid Laal-Dehghani ◽  
Faezeh Mashhoori ◽  
Bibi Sedigheh Fazly Bazzaz ◽  
...  
Keyword(s):  
Dry Powder Inhaler ◽  
Pulmonary Delivery ◽  
Dry Powder ◽  
Scanning Calorimetry ◽  
Porous Particles ◽  
Gentamicin Sulfate ◽  
Freeze Dried ◽  
Emulsification Solvent Evaporation

Purpose: Direct delivery of aminoglycosides to the lungs was under extensive evaluations during the last decades. Because of large particle size, low density and porous structure, large porous particles (LPPs) are versatile carriers for this purpose. In this study, poly (lactic-co-glycolic acid) (PLGA) LPPs encapsulating gentamicin sulfate were prepared and in vitro characteristics of their freeze-dried powder as a dry powder inhaler (DPI) were evaluated. Methods: To prepare PLGA LPPs, a double emulsification-solvent evaporation method was optimized and gentamicin sulfate was post-loaded in the LPPs. In vitro characteristics including morphological features, thermal behavior, aerodynamic profile and cumulative drug release were evaluated by the scanning electron microscope (SEM), differential scanning calorimetry (DSC), next-generation cascade impactor (NGI) and Franz diffusion cell respectively. Results: The obtained results revealed that the preparation method was capable to produce spherical large homogenous highly porous particles. 94% of gentamicin sulfate released from LPPs up to 30 minutes. Mass median aerodynamic diameter (MMAD) and fine particle fraction (FPF) were 4.9 µm and 39% respectively. Conclusion: In this study, dry powder formulation composed of PLGA LPPs encapsulating gentamicin sulfate showed a promising in vitro behavior as a pulmonary delivery carrier. Improvements on the aerodynamic behavior and in vivo evaluations recommended for further developments.

Formulation and In Vivo Evaluation of Effervescent Inhalable Carrier Particles for Pulmonary Delivery of Nanoparticles

2008 ◽  
Vol 34 (9) ◽  
pp. 943-947 ◽  
Author(s):  
Shirzad Azarmi ◽  
Raimar Löbenberg ◽  
Wilson. H. Roa ◽  
Shusheng Tai ◽  
W. H. Finlay
Keyword(s):  
Pulmonary Delivery ◽  
In Vivo Evaluation

In Vitro and In Vivo Performance of Novel Spray Dried Andrographolide Loaded Scleroglucan Based Formulation for Dry Powder Inhaler

2017 ◽  
Vol 14 (7) ◽  
Author(s):  
Ashwin Jagannath Mali ◽  
Chellampillai Bothiraja ◽  
Ravindra Nandlal Purohit ◽  
Atmaram Pandurang Pawar
Keyword(s):  
Dry Powder Inhaler ◽  
Dry Powder ◽  
Spray Dried
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