Calibration transfer between modelled and commercial pharmaceutical tablet for API quantification using backscattering NIR, Raman and transmission Raman spectroscopy (TRS)

2021 ◽  
Vol 194 ◽  
pp. 113766
Author(s):  
Xiao Wang ◽  
Dan-Zhuo Mao ◽  
Yong-Jian Yang
Keyword(s):  
Raman Spectroscopy ◽  
Calibration Transfer ◽  
Pharmaceutical Tablet ◽  
Transmission Raman

Analytical Solution to the Depth-of-Origin Profile of Transmission Raman Spectroscopy in Turbid Media Based on the Kubelka–Munk Model

2019 ◽  
Vol 73 (9) ◽  
pp. 1061-1073
Author(s):  
Jun Zhao
Keyword(s):  
Raman Spectroscopy ◽  
Analytical Formula ◽  
Turbid Media ◽  
Optical Parameters ◽  
Direct Measurements ◽  
Model Sample ◽  
Transmission Raman ◽  
The One ◽  
The Relationship ◽  
Better Than

An analytical formula to the depth-of-origin profile of transmission Raman spectroscopy in turbid media was derived from the one-dimensional (1D) Kubelka–Munk model. The depth-of-origin profile of the transmitted Raman is proportional to the excitation intensity profile and the transmittance profile, which are two functions of similar forms. The effect of scattering, absorption, and signal-enhancing reflectors are incorporated into the formula. Depth-of-origin profile of a model sample was measured at better than 0.2 mm resolution and fits the formula reasonably well. Conical reflective cavities placed at the front and/or back of the sample enhanced the signal significantly; the relationship among the enhancement functions is verified by the formula. Optical parameters derived from the fitting are compared to theoretical value predicted by optical ray tracing and direct measurements; discrepancies are related to deficiency of the 1D Kubelka–Munk model.

Pharmaceutical polymorphs quantified with transmission Raman spectroscopy

2011 ◽  
Vol 43 (2) ◽  
pp. 280-285 ◽  
Author(s):  
Cushla M. McGoverin ◽  
Michael D. Hargreaves ◽  
Pavel Matousek ◽  
Keith C. Gordon
Keyword(s):  
Raman Spectroscopy ◽  
Transmission Raman

Calibration Transfer of a Quantitative Transmission Raman PLS Model: Direct Transfer vs. Global Modeling

2017 ◽  
Vol 12 (4) ◽  
pp. 347-356 ◽  
Author(s):  
Douglas Steinbach ◽  
Carl A. Anderson ◽  
Gary McGeorge ◽  
Benoit Igne ◽  
Robert W. Bondi ◽  
...  
Keyword(s):  
Direct Transfer ◽  
Global Modeling ◽  
Calibration Transfer ◽  
Transmission Raman

Protein and Oil Composition Predictions of Single Soybeans by Transmission Raman Spectroscopy

2012 ◽  
Vol 60 (33) ◽  
pp. 8097-8102 ◽  
Author(s):  
Matthew V. Schulmerich ◽  
Michael J. Walsh ◽  
Matthew K. Gelber ◽  
Rong Kong ◽  
Matthew R. Kole ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Oil Composition ◽  
Transmission Raman

Determination of Depth in Transmission Raman Spectroscopy in Turbid Media Using a Beam Enhancing Element

2017 ◽  
Vol 71 (8) ◽  
pp. 1849-1855 ◽  
Author(s):  
Martha Z. Vardaki ◽  
Hannah Sheridan ◽  
Nicholas Stone ◽  
Pavel Matousek
Keyword(s):  
Raman Spectroscopy ◽  
Turbid Media ◽  
Transmission Raman

Temporal and Spatial Resolution in Transmission Raman Spectroscopy

2010 ◽  
Vol 64 (1) ◽  
pp. 52-60 ◽  
Author(s):  
Neil Everall ◽  
Pavel Matousek ◽  
Neil Macleod ◽  
Kate L. Ronayne ◽  
Ian P. Clark
Keyword(s):  
Raman Spectroscopy ◽  
Spatial Resolution ◽  
Transmission Raman ◽  
Temporal And Spatial
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