Evaluation of Transmission Raman spectroscopy and NIR Hyperspectral Imaging for the assessment of content uniformity in solid oral dosage forms

2021 ◽  
pp. 105963
Author(s):  
Netsanet Fekadu Belay ◽  
Stefan Busche ◽  
Valentina Manici ◽  
Manuela Shaukat ◽  
Sven-Oliver Arndt ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Hyperspectral Imaging ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Content Uniformity ◽  
Transmission Raman ◽  
Solid Oral Dosage Forms ◽  
Oral Dosage Forms

scholarly journals Multi-Analytical Framework to Assess the In Vitro Swallowability of Solid Oral Dosage Forms Targeting Patient Acceptability and Adherence

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 411
Author(s):  
Abdul Latif Ershad ◽  
Ali Rajabi-Siahboomi ◽  
Shahrzad Missaghi ◽  
Daniel Kirby ◽  
Afzal Rahman Mohammed
Keyword(s):  
Hydroxypropyl Methylcellulose ◽  
Analytical Framework ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Surface Erosion ◽  
World Population ◽  
Swallowing Problems ◽  
Solid Oral Dosage Forms ◽  
Oral Dosage Forms

A lack of effective intervention in addressing patient non-adherence and the acceptability of solid oral dosage forms combined with the clinical consequences of swallowing problems in an ageing world population highlight the need for developing methods to study the swallowability of tablets. Due to the absence of suitable techniques, this study developed various in vitro analytical tools to assess physical properties governing the swallowing process of tablets by mimicking static and dynamic stages of time-independent oral transitioning events. Non-anatomical models with oral mucosa-mimicking surfaces were developed to assess the swallowability of tablets; an SLA 3D printed in vitro oral apparatus derived the coefficient of sliding friction and a friction sledge for a modified tensometer measured the shear adhesion profile. Film coat hydration and in vitro wettability was evaluated using a high-speed recording camera that provided quantitative measurements of micro-thickness changes, simulating static in vivo tablet–mucosa oral processing stages with artificial saliva. In order to ascertain the discriminatory power and validate the multianalytical framework, a range of commonly available tablet coating solutions and new compositions developed in our lab were comparatively evaluated according to a quantitative swallowability index that describes the mathematical relationship between the critical physical forces governing swallowability. This study showed that the absence of a film coat significantly impeded the ease of tablet gliding properties and formed chalky residues caused by immediate tablet surface erosion. Novel gelatin- and λ-carrageenan-based film coats exhibited an enhanced lubricity, lesser resistance to tangential motion, and reduced stickiness than polyvinyl alcohol (PVA)–PEG graft copolymer, hydroxypropyl methylcellulose (HPMC), and PVA-coated tablets; however, Opadry® EZ possessed the lowest friction–adhesion profile at 1.53 a.u., with the lowest work of adhesion profile at 1.28 J/mm2. For the first time, the in vitro analytical framework in this study provides a fast, cost-effective, and repeatable swallowability ranking method to screen the in vitro swallowability of solid oral medicines in an effort to aid formulators and the pharmaceutical industry to develop easy-to-swallow formulations.

Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Piroxicam

2014 ◽  
Vol 103 (2) ◽  
pp. 367-377 ◽  
Author(s):  
Igor E. Shohin ◽  
Julia I. Kulinich ◽  
Galina V. Ramenskaya ◽  
Bertil Abrahamsson ◽  
Sabine Kopp ◽  
...  
Keyword(s):  
Immediate Release ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Solid Oral Dosage Forms ◽  
Oral Dosage Forms

Biowaiver Monographs for Immediate-Release Solid Oral Dosage Forms: Quinine Sulfate

2012 ◽  
Vol 101 (2) ◽  
pp. 499-508 ◽  
Author(s):  
Stefanie Strauch ◽  
Jennifer B. Dressman ◽  
Vinod P. Shah ◽  
Sabine Kopp ◽  
James E. Polli ◽  
...  
Keyword(s):  
Immediate Release ◽  
Dosage Forms ◽  
Quinine Sulfate ◽  
Oral Dosage ◽  
Solid Oral Dosage Forms ◽  
Oral Dosage Forms

Difficulties swallowing solid oral dosage forms in a general practice population: prevalence, causes, and relationship to dosage forms

2012 ◽  
Vol 69 (4) ◽  
pp. 937-948 ◽  
Author(s):  
Julia T. Schiele ◽  
Renate Quinzler ◽  
Hans-Dieter Klimm ◽  
Markus G. Pruszydlo ◽  
Walter E. Haefeli
Keyword(s):  
General Practice ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Population Prevalence ◽  
Practice Population ◽  
Solid Oral Dosage Forms ◽  
Oral Dosage Forms

Dehydration and Stabilization of a Reactive Tertiary Hydroxyl Group in Solid Oral Dosage Forms of BMS-779788

2016 ◽  
Vol 105 (4) ◽  
pp. 1478-1488 ◽  
Author(s):  
Monica L. Adams ◽  
Vijayata Sharma ◽  
Madhushree Gokhale ◽  
Yande Huang ◽  
Kevin Stefanski ◽  
...  
Keyword(s):  
Dosage Forms ◽  
Oral Dosage ◽  
Hydroxyl Group ◽  
Solid Oral Dosage Forms ◽  
Oral Dosage Forms ◽  
Tertiary Hydroxyl

Recent Advances in the Development of Solid Oral Dosage Forms

2020 ◽  
pp. 53-78
Author(s):  
Mohammed Tahir Ansari ◽  
Farheen Mohd Sami ◽  
Mohammad Saquib Hasnain ◽  
Shahnaz Majeed ◽  
Sadat Ali
Keyword(s):  
Dosage Forms ◽  
Oral Dosage ◽  
Recent Advances ◽  
Solid Oral Dosage Forms ◽  
Oral Dosage Forms
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