Differential pulse stripping voltammetric determination of paracetamol in pharmaceutical tablet samples using murexide modified carbon paste electrode

As an acetyl aniline drug, paracetamol (PA) has antipyretic and analgesic functions, which is suitable for the remedy of fever, headache and joint ache. The murexide modified carbon paste electrode was characterized by cyclic voltammetry and electrochemical impedance spectroscopy and compared with bare carbon paste electrode. In this study, murexide-carbon paste electrode (MXCPE) was described for the differential pulse stripping voltammetric determination of paracetamol in pharmaceutical tablet sample. The MXCPE exhibited a better electrocatalytical behavior for the oxidation of PA as evidenced by nearly two folds of current enhancement and a shift of the onset potential by 65 mV in comparison with a bare carbon paste electrode. Differential pulse stripping voltammetry peak currents of PA increased linearly with their concentrations in the ranges of 5-1000 mM with a detection limit of 0.09 mM (S/N = 3). The determination of the analyte in pharmaceutical samples was found in the range 97.6-106.0% of the theoretical values and a recovery result between 94.6 and 96.8% was obtained. For selective determination of PA in the presence of AA was successfully performed.

Analysis on Bulk Pharmaceutical Formulation, Validation and Estimation Using Levetiracetam Methods

A new sensitive, specific, direct, exact and correct RP-HPLC technique is established and authenticated to estimate Levetiracetam in Majority and Pharmaceutical Tablet Formulations. An isocratic, turned around period HPLC system might have been created should differentiate the pill starting with the corruption products, Phenomenex Gemini 5µ C18 (2) 100A (250 x 4.60mm, 5 µ) section. Hamilton syringe (705 NR, 50 µL) might have been utilized to injecting example Furthermore standard result. The versatile stage comprises about mixture of Methanol: Acetonitrile in the proportion (90:10 v/v) toward A stream rate about 1.0 ml /min. UV identification might have been performed toward 210 nm. The linearity might have been made for Levetiracetam in the extent from claiming 5- 30µg/ml for relationship coefficient about 0.9997. LOD Also LOQ were found will make 0.076µg/ml Furthermore 0.23µg/ml individually. Maintenance duration of the time of Levetiracetam were found with make 2.281min and 2.274min. % recuperation might have been discovered on be 99.78-100.45 What's more %RSD might have been found for over ±2. Those system needs been approved as stated by ICH rules to linearity, precision, accuracy, robustness, ruggedness, LOD furthermore LOQ. Those produced approved system might have been effectively connected to dependable quantification about Levetiracetam to mass and pharmaceutical measurement type.