Evaluation and Management of Pulmonary Hypertension in Children with Bronchopulmonary Dysplasia

2017 ◽  
Vol 188 ◽  
pp. 24-34.e1 ◽  
Author(s):  
Usha Krishnan ◽  
Jeffrey A. Feinstein ◽  
Ian Adatia ◽  
Eric D. Austin ◽  
Mary P. Mullen ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Bronchopulmonary Dysplasia ◽  
Hypertension In Children

Pulmonary hypertension in infancy and childhood

2003 ◽  
Vol 13 (3) ◽  
pp. 219-227 ◽  
Author(s):  
Matthias Gorenflo ◽  
Mathias Nelle ◽  
Ph. A. Schnabel ◽  
Michael V. Ullmann
Keyword(s):  
Pulmonary Hypertension ◽  
Bronchopulmonary Dysplasia ◽  
Primary Pulmonary Hypertension ◽  
Special Focus ◽  
Morphological Alterations ◽  
Functional Aspects ◽  
Infancy And Childhood ◽  
Long Term Prognosis ◽  
Hypertension In Children

In this review, we discuss current concepts in the pathogenesis and management of pulmonary hypertension affecting infants and children, with special focus on left-to-right shunting, bronchopulmonary dysplasia, and primary pulmonary hypertension.In patients of these ages, functional aspects, such as an imbalance between vasoconstricting and vasodilating mechanisms, and morphological alterations of the vessel wall, contribute to the pulmonary hypertension. In the past decades, strategies have emerged for treatment that are targeted at the pathophysiological basis. Thus, in patients with left-to-right shunting and pulmonary hypertension after intra-cardiac repair, treatment with nitric oxide has been introduced effectively, while treatment with prostanoids, such as iloprost, is under investigation. In patients with pulmonary hypertension and bronchopulmonary dysplasia, therapeutic strategies focus on the underlying chronic lung disease and use of vasodilators. The pathogenesis of primary pulmonary hypertension in children remains as yet unclear, although treatment with prostanoids has proven effectively to improve the long-term prognosis.

scholarly journals RISK FACTORS AND ECHOCARDIOGRAPHIC DIAGNOSIS OF PULMONARY HYPERTENSION IN CHILDREN WITH BRONCHOPULMONARY DYSPLASIA

2017 ◽  
Vol 21 (2) ◽  
pp. 259-269
Author(s):  
E.A. Degtyareva ◽  
◽  
D.Y. Ovsyannikov ◽  
N.O. Zaitseva ◽  
A.A. Shokin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pulmonary Hypertension ◽  
Bronchopulmonary Dysplasia ◽  
Hypertension In Children

scholarly journals PULMONARY HYPERTENSION IN INFANTS WITH BRONCHOPULMONARY DYSPLASIA: CAUSES, DIAGNOSIS, TREATMENT

2021 ◽  
Vol 11 (4(42)) ◽  
pp. 53-59
Author(s):  
A. Menshykova ◽  
D. Dobryanskyy
Keyword(s):  
Pulmonary Hypertension ◽  
Bronchopulmonary Dysplasia ◽  
Total Duration ◽  
Cardiovascular Complication ◽  
Diagnosis And Treatment ◽  
Pulmonary Vasculature ◽  
Vascular Abnormalities ◽  
Duration Of Hospital Stay ◽  
Hypertension In Children

Bronchopulmonary dysplasia (BPD) is a leading chronic pathology of premature infants, which changes the structure of the lungs and disrupts the development of pulmonary vessels. The most important cardiovascular complication of BPD is the development of pulmonary hypertension, which is diagnosed in about 25 % of severely ill infants. Pulmonary hypertension associated with BPD develops due to lung vascular abnormalities and remodeling of the pulmonary vasculature, both of which lead to an increase in vascular resistance and the development of right ventricular heart failure. The occurrence of this complication worsens the prognosis of survival in infants with BPD, prolongs the total duration of hospital stay, adversely affects long-term somatic and neurological development and increases the frequency of re-hospitalizations. All this justifies the need for timely diagnosis and treatment of pulmonary hypertension in children with BPD. This review presents new data, for the definition, diagnosis, and treatment of pulmonary hypertension associated with BPD.

Somatic growth and the risks of bronchopulmonary dysplasia and pulmonary hypertension: connecting epidemiology and physiology

2019 ◽  
Vol 97 (3) ◽  
pp. 197-205 ◽  
Author(s):  
Mark A. Underwood ◽  
Stephen Wedgwood ◽  
Satyan Lakshminrusimha ◽  
Robin H. Steinhorn
Keyword(s):  
Pulmonary Hypertension ◽  
Bronchopulmonary Dysplasia ◽  
Somatic Growth ◽  
Postnatal Growth ◽  
Pulmonary Complications ◽  
Growth Restriction ◽  
Extreme Prematurity ◽  
Poor Growth ◽  
Increased Risk ◽  
Poor Nutrition

In the premature infant, poor growth in utero (fetal growth restriction) and in the first weeks of life (postnatal growth restriction) are associated with increased risk for bronchopulmonary dysplasia and pulmonary hypertension. In this review, we summarize the epidemiologic data supporting these associations, present a novel rodent model of postnatal growth restriction, and review 5 promising mechanisms by which poor nutrition may affect the developing lung. These observations support the hypothesis that nutritional and (or) pharmacologic interventions early in life may be able to decrease risk of the pulmonary complications of extreme prematurity.

scholarly journals Epidemiology and Clinical Management of Pulmonary Hypertension in Children

2012 ◽  
Vol 42 (8) ◽  
pp. 513 ◽  
Author(s):  
Hongfang Jin ◽  
Jinyan Yang ◽  
Qingyou Zhang ◽  
Junbao Du
Keyword(s):  
Pulmonary Hypertension ◽  
Clinical Management ◽  
Hypertension In Children
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