scholarly journals A prospective comparative evaluation of persistent respiratory morbidity in esophageal atresia and congenital diaphragmatic hernia survivors

2009 ◽  
Vol 44 (9) ◽  
pp. 1683-1690 ◽  
Author(s):  
Saskia J. Gischler ◽  
Monique H.M. van der Cammen-van Zijp ◽  
Petra Mazer ◽  
Gerard C. Madern ◽  
Nikolaas M.A. Bax ◽  
...  
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Esophageal Atresia ◽  
Diaphragmatic Hernia ◽  
Comparative Evaluation ◽  
Respiratory Morbidity

scholarly journals Respiratory Syncytial Virus Prophylaxis in Infants With Congenital Diaphragmatic Hernia in the Canadian Respiratory Syncytial Virus Evaluation Study of Palivizumab, 2005–2017

2018 ◽  
Vol 69 (6) ◽  
pp. 980-986 ◽  
Author(s):  
Doyoung Kim ◽  
Mahwesh Saleem ◽  
Bosco Paes ◽  
Ian Mitchell ◽  
Krista L Lanctôt
Keyword(s):  
Respiratory Syncytial Virus ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Respiratory Illness ◽  
Evaluation Study ◽  
Cox Proportional Hazards ◽  
Respiratory Morbidity ◽  
Increased Risk ◽  
Syncytial Virus ◽  
Tract Infections

Abstract Background Infants with congenital diaphragmatic hernia (CDH) are at an increased risk of respiratory morbidity from recurrent respiratory tract infections including those from respiratory syncytial virus (RSV). Prospective studies on RSV prophylaxis in CDH infants are limited. We determined the risk of respiratory illness– and RSV-related hospitalizations (RIH and RSVH, respectively) among infants prophylaxed for CDH, standard indications (SIs) and those without increased risk (NR). Methods The prospective Canadian Respiratory Syncytial Virus Evaluation Study of Palivizumab (CARESS) registry was searched for infants who received palivizumab during 12 RSV seasons (2005–2017) in Canada. Cox proportional hazards analyses were conducted to compare RIH and RSVH risks across the groups adjusted for potential confounders. Results In total, 21 107 infants (201 CDH, 389 NR, and 20 517 SI) were included. RIH incidences were 10.0% (CDH), 2.1% (NR), and 6.2% (SI). CDH patients had a significantly higher RIH hazard compared with NR (hazard ratio [HR], 3.6 [95% confidence interval {CI}, 1.5–8.8]; P = .005) but not SI (HR, 1.2 [95% CI, .8–2.0]; P = .379). RSVH incidences were 0.6%, 0.3%, and 1.5% for CDH, NR, and SI, respectively. RSVH risk was similar across groups (SI: HR, 0.0, P = .922; NR: HR, 0.0, P = .934). Conclusions CDH infants had a 3-fold increased risk of RIH compared to NR but not SI infants. RSVH risk was similar with low RSVH incidences across all groups, implying that CDH infants may benefit from palivizumab during the RSV season, similar to other high-risk groups. Clinical Trials Registration NCT00420966.

scholarly journals Congenital diaphragmatic hernia associated with esophageal atresia, tracheoesophageal fistula and total anomalous pulmonary venous connection in a premature twin newborn

2019 ◽  
Vol 76 (7) ◽  
pp. 745-748
Author(s):  
Djordje Savic ◽  
Blagoje Grujic ◽  
Nikola Stankovic ◽  
Maja Milickovic ◽  
Zoran Stankovic ◽  
...  
Keyword(s):  
Mortality Rate ◽  
Congenital Diaphragmatic Hernia ◽  
Esophageal Atresia ◽  
Diaphragmatic Hernia ◽  
Congenital Heart ◽  
Gastroesophageal Junction ◽  
Rare Condition ◽  
Team Work ◽  
Adequate Treatment ◽  
Anomalous Pulmonary Venous Connection

Introduction. Congenital diaphragmatic hernia (CDH) with concomitant esophageal atresia (EA) and tracheo-esophageal fistula (TEF) is a very rare condition, with a high mortality rate. Prematurity and congenital heart anomalies additionally increase the mortality rate. This situation is a great challenge for clinicians, requiring multidisciplinary work and adequate treatment strategy. Case report. We presented a premature twin newborn at the gestational age of 33/34 weeks with body mass of 1690 g. The existence of the left CDH was established on prenatal ultrasound exam in the 24th gestational week, and the diagnosis of EA with TEF was made on admittance to our hospital. The cardiac ultrasound exam revealed the total anomalous pulmonary venous connection (TAPVC). The first operation was performed on the day of admittance and consisted of left subcostal laparotomy, diaphragmatic repair, elastic occlusion of the gastroesophageal junction and gastrostomy. The ligation of TEF and esophagoplasty were done 13 days later in the second operation. The lethal outcome during the esophagoplasty was caused by the crisis of pulmonary hypertension and associated congenital heart anomaly (TAPVC). The presence of CDH and EA/TEF in association with TAPVC in a twin newborn has not been reported before in the literature. Conclusion. The treatment of newborns with CDH and EA/TEF requires multidisciplinary well-coordinated team work of pediatric surgeons, anaesthesiologists, neonatologists and pulmologists. The standard protocol for the management does not exist, but well-planned staged operations could enable greater survival rate.

scholarly journals A Rare Association of Congenital Diaphragmatic Hernia with Lower Esophageal Atresia and Perforation

2010 ◽  
Vol 2010 ◽  
pp. 1-2 ◽  
Author(s):  
Narendra Kumar Are ◽  
K. Nagarjuna ◽  
Lavanya Kannaiyan
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Esophageal Atresia ◽  
Diaphragmatic Hernia ◽  
Rare Occurrence ◽  
Rare Association

Congenital diaphragmatic hernia is known to be associated with esophageal atresia, which is a rare association. We report a rare occurrence of congenital diaphragmatic hernia and lower esophageal atresia.

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