Blue-to-red light triggered nitric oxide release in cytotoxic/cytostatic ruthenium nitrosyl complexes bearing biomimetic ligands

2021 ◽  
Vol 421 ◽  
pp. 113520
Author(s):  
Elena D. Stolyarova ◽  
Artem A. Mikhailov ◽  
Anton A. Ulantikov ◽  
Julia A. Eremina ◽  
Lyubov S. Klyushova ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Red Light ◽  
Nitric Oxide Release ◽  
Nitrosyl Complexes ◽  
Ruthenium Nitrosyl

scholarly journals Nitric oxide (NO) photo-release in a series of ruthenium–nitrosyl complexes: new experimental insights in the search for a comprehensive mechanism

2019 ◽  
Vol 43 (2) ◽  
pp. 755-767 ◽  
Author(s):  
Max Roose ◽  
Marine Tassé ◽  
Pascal G. Lacroix ◽  
Isabelle Malfant
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Release ◽  
Nitrosyl Complexes ◽  
Ruthenium Nitrosyl

The mechanism of nitric oxide release is investigated along a series of 1–3 “push–pull” ruthenium nitrosyl complexes.

scholarly journals Nitric oxide release from a photoactive water-soluble ruthenium nitrosyl. Biological effects

2018 ◽  
Vol 71 (11-13) ◽  
pp. 1690-1703 ◽  
Author(s):  
Meredith A. Crisalli ◽  
Lilian P. Franco ◽  
Bruno R. Silva ◽  
Alda K. M. Holanda ◽  
Lusiane M. Bendhack ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Biological Effects ◽  
Water Soluble ◽  
Nitric Oxide Release ◽  
Ruthenium Nitrosyl

scholarly journals How does the acidic milieu interfere in the capability of ruthenium nitrosyl complexes to release nitric oxide?

2020 ◽  
Vol 44 (3) ◽  
pp. 773-779
Author(s):  
Renato Pereira Orenha ◽  
Nelson Henrique Morgon ◽  
Julia Contreras-García ◽  
Graziele Cappato Guerra Silva ◽  
Glaucio Régis Nagurniak ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Ruthenium Complexes ◽  
Reduction Reaction ◽  
Nitrosyl Complexes ◽  
Ruthenium Nitrosyl ◽  
Release Mechanisms ◽  
No Release

The nitric oxide has a well-defined role in biology. The ruthenium complexes are model for study NO release mechanisms. The proton increases the capability of these compounds to release NO after reduction reaction or of the light supported reaction.

The Role of π–Donor/Acceptor trans Effect on The NO release in Ruthenium Nitrosyl Complexes: A Computational Insight

2021 ◽  
Author(s):  
Renato Pereira Orenha ◽  
Nelson Morgon ◽  
Graziele Cappato Guerra Silva ◽  
Giovanni Finoto Caramori ◽  
Renato Luis Tame Parreira
Keyword(s):  
Nitric Oxide ◽  
Ruthenium Complexes ◽  
Release Mechanism ◽  
Trans Effect ◽  
Nitrosyl Complexes ◽  
Ruthenium Nitrosyl ◽  
No Release ◽  
Donor Acceptor ◽  
Model Structures

The nitric oxide (NO) molecule is associated to diverse biochemical routes. Ruthenium complexes are commonly used as model structures to control the NO availability. Here, the NO release mechanism in...

Near-IR light-induced photorelease of nitric oxide (NO) on ruthenium nitrosyl complexes: formation, reactivity, and biological effects

2020 ◽  
Vol 49 (31) ◽  
pp. 10772-10785 ◽  
Author(s):  
Bishnubasu Giri ◽  
Taruna Saini ◽  
Sadananda Kumbhakar ◽  
Kalai Selvan K ◽  
Arabinda Muley ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Prostate Cancer Cell ◽  
Biological Effects ◽  
Cancer Cell Line ◽  
Prostate Cancer Cell Line ◽  
Nitrosyl Complexes ◽  
Ruthenium Nitrosyl ◽  
Near Ir ◽  
Line P ◽  
Ir Light

Two new polypyridyl backboned ruthenium nitrosyl complexes have been synthesized which shows efficient NO photorelease and exhibits significant phototoxicity upon irradiation with the visible light in the VCaP prostate cancer cell line.

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