Medicinal Chemistry Strategies Towards SO2 Donors as Research Tools and Potential Therapeutics

SO2 is emerging as a possible endogenous signaling molecule in mammals. In addition, SO2 has also shown pharmacological effects, presenting SO2 as a promising potential therapeutic agent. The past decade has witnessed steady advances in the development of small molecule-based SO2 prodrugs/donors with varied release mechanisms. Herein, we summarize various strategies employed for SO2 prodrug design. The remaining challenges and issues will also be discussed.

NAADP: From Discovery to Mechanism

Nicotinic acid adenine dinucleotide 2’-phosphate (NAADP) is a naturally occurring nucleotide that has been shown to be involved in the release of Ca2+ from intracellular stores in a wide variety of cell types, tissues and organisms. Current evidence suggests that NAADP may function as a trigger to initiate a Ca2+ signal that is then amplified by other Ca2+ release mechanisms. A fundamental question that remains unanswered is the identity of the NAADP receptor. Our recent studies have identified HN1L/JPT2 as a high affinity NAADP binding protein that is essential for the modulation of Ca2+ channels.

Neuromuscular Analysis Of Various Release Mechanisms In Archery: A Study Of The Preparatory Response Between Trigger And Back-Tension Releases

Archery was originally a tool for hunting but since has been transformed into a sport. Archery technology has evolved with little focus as to its effect on humans. Archery requires high levels of concentration and static muscle activity, which has not been analyzed to be successful. By observing the muscle activity in the bow arm and measuring the vibration effects from the bow, it was determined a presence of an impact to the human arm, which the human then creates anticipation for and braces against. To mitigate this anticipation, another technology was introduced to create a surprise factor in the shooting. To reduce the frequency of archers bracing up for the shot, knowledge of when the shot is going off was taken away. It was observed that the new technology did introduce a surprise factor, but it did not reduce the occurrences of preparatory muscle activation in the human arm.