Transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 contribute to the progression of colonic inflammation in dextran sulfate sodium-induced colitis in mice: Links to calcitonin gene-related peptide and substance P

Der vorliegende Artikel analysiert die aktuellen präklinischen Studien zur Beteiligung peripherer Rezeptoren und Neuromediatoren an den antihyperalgetischen Effekten der Akupunktur. Die Datenbanken von PubMed, Scopus und Web of Science wurden mittels einer erweiterten Reviewmethode durchsucht. Anhand einer vordefinierten Suchstrategie wurden die präklinischen Artikel ausgewählt, welche die Rolle peripherer Rezeptoren und Neuromediatoren auf die schmerzkontrollierenden Effekte der Akupunktur bei Ratten und Mäusen untersuchten. Die Suche ergab 456 Artikel, von denen 29 die Einschlusskriterien der Studie erfüllten. Die ausgewählten Artikel behandelten folgende periphere Rezeptoren: Opioid- (n=9), Adenosin- (n=5), Cannabinoid- (n=5), Transient-Receptor-Potential-Vanilloid- (TRPV; n=3), Histamin- (n=2), adrenerge (n=1), muskarinerge (n=1), Corticotropin-releasing Factor (CRF)-(n=2), IL-1- (n=1) und Endothelinrezeptoren (n=1). Folgende Neuromediatoren korrelierten mit peripheren Effekten der Schmerzkontrolle: Opioidpeptide (n=4), Adenosin (n=3), Histamin (n=1), Substanz P (n=1), Calcitonin Gene-related Peptide (CGRP) (n=1), Anandamid (n=1), NO (n=1) sowie Noradrenalin (n=1).

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Cardioprotection by ischemic postconditioning is lost in isolated perfused heart from diabetic rats: Involvement of transient receptor potential vanilloid 1, calcitonin gene-related peptide and substance P

Regulatory Peptides ◽

10.1016/j.regpep.2011.04.004 ◽

2011 ◽

Vol 169 (1-3) ◽

pp. 49-57 ◽

Cited By ~ 34

Author(s):

Jing-Yi Ren ◽

Jun-Xian Song ◽

Ming-Yu Lu ◽

Hong Chen

Keyword(s):

Substance P ◽

Transient Receptor Potential ◽

Receptor Potential ◽

Diabetic Rats ◽

Ischemic Postconditioning ◽

Transient Receptor Potential Vanilloid ◽

Isolated Perfused Heart ◽

Perfused Heart ◽

Calcitonin Gene ◽

Transient Receptor

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Ghrelin attenuated hyperalgesia induced by chronic nitroglycerin: CGRP and TRPV1 as targets for migraine management

Cephalalgia ◽

10.1177/0333102417748563 ◽

2017 ◽

Vol 38 (11) ◽

pp. 1716-1730 ◽

Cited By ~ 10

Author(s):

Fereshteh Farajdokht ◽

Gisou Mohaddes ◽

Dariush Shanehbandi ◽

Pouran Karimi ◽

Shirin Babri

Keyword(s):

Mrna Expression ◽

Transient Receptor Potential ◽

Receptor Potential ◽

Calcitonin Gene Related Peptide ◽

Transient Receptor Potential Vanilloid ◽

Conditioned Place Aversion ◽

Trigeminovascular System ◽

Related Peptide ◽

Calcitonin Gene ◽

Transient Receptor

Background According to the neurovascular theory of migraine, activation of the trigeminovascular system contributes to the development of migraine. This study examined the effects of chronic intraperitoneal ghrelin (150 µg/kg) treatment on the development of chronic migraine induced by intermittent injection of nitroglycerin 10 mg/kg. Methods Baseline and post-drug (2 h following nitroglycerin injection) mechanical and thermal sensitivity were assessed by von Frey hair and tail immersion tests, respectively on days 1, 3, 5, 7, 9 and 11. Moreover, we investigated the effect of ghrelin treatment on nitroglycerin-induced aversive behavior by using a two-chamber conditioned place aversion paradigm. At the end of behavioral testing, on day 11, animals were sacrificed and plasma concentration of calcitonin gene-related peptide was measured using a rat-specific enzyme-linked immunosorbent assay kit. Also, real time polymerase chain reaction was used to quantify mRNA expression of calcitonin gene-related peptide and transient receptor potential vanilloid 1 in the trigeminal ganglion. Results Our results indicated that nitroglycerin activated the trigeminovascular system, which was reflected by mechanical and thermal hypersensitivity and elevation of mRNA expression of calcitonin gene-related peptide and transient receptor potential vanilloid-1, as migraine markers, and plasma calcitonin gene-related peptide levels. Moreover, chronic nitroglycerin injection induced conditioned place aversion and body weight loss. Nevertheless, ghrelin modulated nitroglycerin-triggered changes in transient receptor potential vanilloid-1 and calcitonin gene-related peptide expression, and mitigated nitroglycerin-induced hyperalgesia. Conclusion These results provide the first convincing evidence that ghrelin has a modulating effect on central sensitization induced by chronic intermittent nitroglycerin, and its antinociceptive effect may be related to a reduction of these factors in the trigeminal ganglion.

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