Comparison of quetiapine immediate- and extended-release formulations for bipolar depression: A systematic review and network meta-analysis of double-blind, randomized placebo-controlled trials

2019 ◽  
Vol 115 ◽  
pp. 121-128 ◽  
Author(s):  
Taro Kishi ◽  
Toshikazu Ikuta ◽  
Kenji Sakuma ◽  
Yuki Matsuda ◽  
Nakao Iwata
Keyword(s):  
Systematic Review ◽  
Extended Release ◽  
Bipolar Depression ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Double Blind ◽  
Extended Release Formulations

Effect of extended-release niacin on plasma lipoprotein(a) levels: A systematic review and meta-analysis of randomized placebo-controlled trials

Metabolism ◽  
2016 ◽  
Vol 65 (11) ◽  
pp. 1664-1678 ◽  
Author(s):  
Amirhosssein Sahebkar ◽  
Željko Reiner ◽  
Luis E. Simental-Mendía ◽  
Gianna Ferretti ◽  
Arrigo F.G. Cicero
Keyword(s):  
Systematic Review ◽  
Extended Release ◽  
Meta Analysis ◽  
Plasma Lipoprotein ◽  
Controlled Trials ◽  
Lipoprotein A

scholarly journals Efficacy and acceptability of mood stabilisers in the treatment of acute bipolar depression: systematic review

2010 ◽  
Vol 196 (4) ◽  
pp. 266-273 ◽  
Author(s):  
Ryan J. Van Lieshout ◽  
Glenda M. MacQueen
Keyword(s):  
Systematic Review ◽  
Bipolar Depression ◽  
Antidepressant Treatment ◽  
Meta Analysis ◽  
Number Needed To Treat ◽  
Mood Stabiliser ◽  
Double Blind ◽  
Manic State ◽  
Gain Switching ◽  
Drug Classes

BackgroundAlthough people with bipolar disorder spend more time in a depressed than manic state, little evidence is available to guide the treatment of acute bipolar depression.AimsTo compare the efficacy, acceptability and safety of mood stabiliser monotherapy with combination and antidepressant treatment in adults with acute bipolar depression.MethodSystematic review and meta-analysis of randomised, double-blind controlled trials.ResultsEighteen studies with a total 4105 participants were analysed. Mood stabiliser monotherapy was associated with increased rates of response (relative risk (RR) = 1.30, 95% CI 1.16–1.44, number needed to treat (NNT) = 10, 95% CI 7–18) and remission (RR = 1.51, 95% CI 1.27–1.79, NNT = 8, 95% CI 5–14) relative to placebo. Combination therapy was not statistically superior to monotherapy. Weight gain, switching and suicide rates did not differ between groups. No differences were found between individual medications or drug classes for any outcome.ConclusionsMood stabilisers are moderately efficacious for acute bipolar depression. Extant studies are few and limited by high rates of discontinuation and short duration. Further study of existing and novel agents is required.

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