Life satisfaction among individuals with opioid use disorder receiving extended-release naltrexone: A 12-week randomized controlled trial and a 36-week follow-up

2021 ◽  
pp. 108656
Author(s):  
Zhanna Gaulen ◽  
Jūratė Šaltytė Benth ◽  
Lars Thore Fadnes ◽  
Ida Halvorsen Brenna ◽  
Lars Tanum
Keyword(s):  
Randomized Controlled Trial ◽  
Life Satisfaction ◽  
Extended Release ◽  
Controlled Trial ◽  
Opioid Use Disorder ◽  
Opioid Use ◽  
Randomized Controlled

scholarly journals Behavioral intervention to reduce opioid overdose among high-risk persons with opioid use disorder: A pilot randomized controlled trial

PLoS ONE ◽  
2017 ◽  
Vol 12 (10) ◽  
pp. e0183354 ◽  
Author(s):  
Phillip Oliver Coffin ◽  
Glenn-Milo Santos ◽  
Tim Matheson ◽  
Emily Behar ◽  
Chris Rowe ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
High Risk ◽  
Behavioral Intervention ◽  
Controlled Trial ◽  
Opioid Use Disorder ◽  
Opioid Overdose ◽  
Opioid Use ◽  
Randomized Controlled ◽  
Pilot Randomized Controlled Trial

Cognitive rehabilitation for individuals with opioid use disorder: A randomized controlled trial

2017 ◽  
Vol 29 (8) ◽  
pp. 1273-1289 ◽  
Author(s):  
Tara Rezapour ◽  
Javad Hatami ◽  
Ali Farhoudian ◽  
Mehmet Sofuoglu ◽  
Alireza Noroozi ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Cognitive Rehabilitation ◽  
Controlled Trial ◽  
Opioid Use Disorder ◽  
Opioid Use ◽  
Randomized Controlled

scholarly journals Trajectory classes of opioid use among individuals in a randomized controlled trial comparing extended-release naltrexone and buprenorphine-naloxone

2019 ◽  
Vol 205 ◽  
pp. 107649 ◽  
Author(s):  
Lesia M. Ruglass ◽  
Jennifer Scodes ◽  
Martina Pavlicova ◽  
Aimee N.C. Campbell ◽  
Skye Fitzpatrick ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Extended Release ◽  
Controlled Trial ◽  
Opioid Use ◽  
Randomized Controlled

scholarly journals Comparing rapid micro-induction and standard induction of buprenorphine/naloxone for treatment of opioid use disorder: Protocol for an open-label, parallel-group, superiority, randomized controlled trial

2020 ◽  
Author(s):  
James S.H. Wong ◽  
Mohammadali Nikoo ◽  
Jean N. Westenberg ◽  
Janet G. Suen ◽  
Jennifer Wong ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Drug Use ◽  
Controlled Trial ◽  
Opioid Use Disorder ◽  
Opioid Use ◽  
Induction Method ◽  
Open Label ◽  
Randomized Controlled ◽  
Parallel Group ◽  
Successful Induction

Background: Buprenorphine/naloxone (Suboxone) is a current first-line treatment for opioid use disorder (OUD). The standard induction method of buprenorphine/naloxone requires patients to be abstinent from opioids and therefore experience withdrawal symptoms prior to induction, which can be a barrier in starting treatment. Rapid micro-induction (micro-dosing) involves the administration of small, frequent does of buprenorphine/naloxone and removes the need for a period of withdrawal prior to the start of treatment. This study aims to compare the effectiveness and safety of rapid micro-induction versus standard induction of buprenorphine/naloxone in patients with OUD. Methods: This is a randomized, open-label, two-arm, superiority, controlled trial comparing the safety and effectiveness of rapid micro-induction versus standard induction of buprenorphine/naloxone for the treatment of OUD. A total of 50 participants with OUD will be randomized at one Canadian hospital. The primary outcome is successful induction of buprenorphine/naloxone with low levels of withdrawal. Secondary outcomes are treatment retention, illicit drug use, self-reported drug use behaviour, craving, pain, physical health, safety, and client satisfaction. Discussion: This is the first randomized controlled trial to compare the effectiveness and safety of rapid micro-induction versus standard induction of buprenorphine/naloxone. This study will thereby generate evidence for a novel induction method which eliminates substantial barriers to the use of buprenorphine/naloxone in the midst of the ongoing opioid crisis.

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