Serine Racemase and D-Serine Transport in Human Placenta and Evidence for a Transplacental Gradient for D-Serine in Humans

2004 ◽  
Vol 11 (5) ◽  
pp. 294-303 ◽  
Author(s):  
Zhong Chen ◽  
Wei Huang ◽  
Sonne R. Srinivas ◽  
Chandra R. Jones ◽  
Vadivel Ganapathy ◽  
...  
Keyword(s):  
Human Placenta ◽  
Serine Racemase

The transfer of pravastatin in the human placenta in women with Antiphospholipid Syndrome

2017 ◽  
Vol 77 (04) ◽  
pp. 379-395
Author(s):  
K Mayer-Pickel ◽  
M Gruber ◽  
B Hirschmugl ◽  
U Lang ◽  
M Cervar-Zivkovic ◽  
...  
Keyword(s):  
Antiphospholipid Syndrome ◽  
Human Placenta

Inhibition of Platelet Aggregation by Human Placenta

1985 ◽  
Vol 54 (02) ◽  
pp. 431-437 ◽  
Author(s):  
M J Dembélé-Duchesne ◽  
A Laghchim Lahlou ◽  
H Thaler-Dao ◽  
A Crastes de Paulet
Keyword(s):  
Fatty Acid ◽  
Platelet Aggregation ◽  
Human Placenta ◽  
Cyclooxygenase Inhibitor ◽  
Synthetase Inhibitor ◽  
Inhibition Of Platelet Aggregation ◽  
Thromboxane Synthetase ◽  
Rabbit Platelets ◽  
High Doses ◽  
Induced Aggregation

SummaryHuman placental cytosol inhibits platelet aggregation induced by high doses of collagen. The aim of this study was to investigate whether this anti-aggregating activity was caused only by the presence of various activities already described in the placenta (an ADP-consuming enzyme, a fatty acid cyclooxygenase inhibitor, and a thromboxane synthetase inhibitor) or whether another factor was present.Heating the cytosol at 50° C for 6 min destroyed the inhibitor of collagen-induced aggregation. ADPase and the AA pathway inhibitors were not modified by this treatment. We therefore show the presence of an additional anti-aggregating factor: it is destroyed by heating at 50° C.We also tested for the presence of an inhibitor of AA release in the placental cytosol using three different methods (rabbit platelets in PRP, washed rabbit platelets, and NRK fibroblasts) but no inhibition could be evidenced.We conclude that this new anti-aggregating factor, which is probably a protein, acts neither through AA release inhibition nor AA cascade inhibition.

Expression pattern of osteopontin (OPN) in the human placenta – correlation with expression of the adhesion molecule CEACAM1

2005 ◽  
Vol 113 (S 1) ◽  
Author(s):  
J Briese ◽  
M Oberndörfer ◽  
B Kelp ◽  
HM Schulte ◽  
T Löning ◽  
...  
Keyword(s):  
Expression Pattern ◽  
Adhesion Molecule ◽  
Human Placenta

METABOLISM OF 17α-HYDROXYPROGESTERONE-4-14C-17α-CAPROATE BY HOMOGENATES OF RAT LIVER AND HUMAN PLACENTA

1961 ◽  
Vol 36 (4) ◽  
pp. 511-519 ◽  
Author(s):  
Margaret Wiener ◽  
Charles I. Lupa ◽  
E. Jürgen Plotz
Keyword(s):  
Rat Liver ◽  
Human Placenta ◽  
Steric Hindrance ◽  
Placental Tissue ◽  
Caproic Acid ◽  
Major Product ◽  
Side Chain ◽  
Anaerobic Conditions ◽  
Prolonged Action ◽  
Long Acting

ABSTRACT 17α-hydroxyprogesterone-4-14C-17α-caproate (HPC), a long-acting progestational agent, was incubated with homogenates of rat liver and human placenta. The rat liver was found to reduce Ring A of HPC under anaerobic conditions to form allopregnane-3β,17α-diol-20-one-17α-caproate and pregnane-3β,17α-diol-20-one-17α-caproate, the allopregnane isomer being the major product. The caproic acid ester was neither removed nor altered during the incubation. Placental tissue did not attack HPC under conditions where the 20-ketone of progesterone was reduced. It is postulated that this absence of attack on the side chain is due to steric hindrance from the caproate ester, and that this may account for the prolonged action of HPC.

Morphometric and Morphological Study of Human Placenta in Hypertensive Females of West U. P. India

2018 ◽  
Vol 4 (3) ◽  
Author(s):  
Chetna Thakur ◽  
Tejendra Singh ◽  
Bhawani Shankar ◽  
Shikha Sharma ◽  
G. S. Bindra
Keyword(s):  
Human Placenta ◽  
Morphological Study

A Time-Resolved Proteotranscriptomic Atlas of the Human Placenta Reveals Pan-Cancer Immunomodulators

2019 ◽  
Author(s):  
Na Ding ◽  
Botao Zhang ◽  
Wantao Ying ◽  
Jie Song ◽  
Zhenghong Chang ◽  
...  
Keyword(s):  
Human Placenta ◽  
Time Resolved ◽  
Pan Cancer
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