scholarly journals Self-assembled filomicelles prepared from polylactide-poly(ethylene glycol) diblock copolymers for sustained delivery of cycloprotoberberine derivatives

2018 ◽  
Vol 26 (3) ◽  
pp. 342-348 ◽  
Author(s):  
Xue Liu ◽  
Yanxiang Wang ◽  
Peng Yun ◽  
Xin Shen ◽  
Feng Su ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Diblock Copolymers ◽  
Sustained Delivery ◽  
Poly Ethylene Glycol ◽  
Self Assembled ◽  
Poly Ethylene

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Copolymers for the Formulation of In Situ Forming Depot Long-Acting Injectables

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 605
Author(s):  
Marie-Emérentienne Cagnon ◽  
Silvio Curia ◽  
Juliette Serindoux ◽  
Jean-Manuel Cros ◽  
Feifei Ng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Surface Erosion ◽  
Sustained Delivery ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene ◽  
Long Acting

This article describes the utilization of (methoxy)poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) ((m)PEG–PTMC) diblock and triblock copolymers for the formulation of in situ forming depot long-acting injectables by solvent exchange. The results shown in this manuscript demonstrate that it is possible to achieve long-term drug deliveries from suspension formulations prepared with these copolymers, with release durations up to several months in vitro. The utilization of copolymers with different PEG and PTMC molecular weights affords to modulate the release profile and duration. A pharmacokinetic study in rats with meloxicam confirmed the feasibility of achieving at least 28 days of sustained delivery by using this technology while showing good local tolerability in the subcutaneous environment. The characterization of the depots at the end of the in vivo study suggests that the rapid phase exchange upon administration and the surface erosion of the resulting depots are driving the delivery kinetics from suspension formulations. Due to the widely accepted utilization of meloxicam as an analgesic drug for animal care, the results shown in this article are of special interest for the development of veterinary products aiming at a very long-term sustained delivery of this therapeutic molecule.

Microencapsulation of cytarabine using poly(ethylene glycol)–poly(ε-caprolactone) diblock copolymers as surfactant agents

2010 ◽  
Vol 36 (4) ◽  
pp. 456-469 ◽  
Author(s):  
Roudayna Diab ◽  
Misara Hamoudeh ◽  
Olivier Boyron ◽  
Abdelhamid Elaissari ◽  
Hatem Fessi
Keyword(s):  
Ethylene Glycol ◽  
Diblock Copolymers ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Poly(ethylene glycol) Self-Assembled Monolayer Island Growth

Langmuir ◽  
2005 ◽  
Vol 21 (7) ◽  
pp. 2981-2987 ◽  
Author(s):  
Jonas Rundqvist ◽  
Jan H. Hoh ◽  
David B. Haviland
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Island Growth ◽  
Self Assembled Monolayer ◽  
Self Assembled ◽  
Poly Ethylene

Controlling the morphology of glyco-nanoparticles in water using block copolymer mixtures: the effect on cellular uptake

2015 ◽  
Vol 6 (45) ◽  
pp. 7812-7820 ◽  
Author(s):  
Aydan Dag ◽  
Hongxu Lu ◽  
Martina Stenzel
Keyword(s):  
Block Copolymer ◽  
Ethylene Glycol ◽  
Cellular Uptake ◽  
Methyl Ether ◽  
Butyl Acrylate ◽  
Diblock Copolymers ◽  
Ethyl Acrylate ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

Poly[(2-(α-d-mannosyloxy)ethyl acrylate)-block-(n-butyl acrylate)], P(ManA-b-BA), and poly[poly(ethylene glycol) methyl ether acrylate]-block-(n-butyl acrylate)], P(OEGMEA-b-BA) diblock copolymers were mixed at various ratios to generate self-assembled structures of different morphologies.

The effect of poly(ethylene glycol)–poly(d,l-lactic acid) diblock copolymers on peptide acylation

2002 ◽  
Vol 80 (1-3) ◽  
pp. 157-168 ◽  
Author(s):  
Andrea Lucke ◽  
Elisabetta Fustella ◽  
Jörg Teßmar ◽  
Andrea Gazzaniga ◽  
Achim Göpferich
Keyword(s):  
Lactic Acid ◽  
Ethylene Glycol ◽  
Diblock Copolymers ◽  
Poly Ethylene Glycol ◽  
Peptide Acylation ◽  
Poly Ethylene
Sign in / Sign up

Export Citation Format

Share Document