Protective effects of colchicine in an experimental model of necrotizing enterocolitis in neonatal rats

2013 ◽  
Vol 183 (1) ◽  
pp. 156-162 ◽  
Author(s):  
Sadik Yurttutan ◽  
Ramazan Ozdemir ◽  
Fuat Emre Canpolat ◽  
Mehmet Yekta Oncel ◽  
Bulent Uysal ◽  
...  
Keyword(s):  
Experimental Model ◽  
Necrotizing Enterocolitis ◽  
Protective Effects ◽  
Neonatal Rats

Protective effects of hydrogen-rich saline on necrotizing enterocolitis in neonatal rats

2013 ◽  
Vol 48 (8) ◽  
pp. 1697-1706 ◽  
Author(s):  
Qingfeng Sheng ◽  
Zhibao Lv ◽  
Wei Cai ◽  
Huanlei Song ◽  
Linxi Qian ◽  
...  
Keyword(s):  
Necrotizing Enterocolitis ◽  
Protective Effects ◽  
Neonatal Rats

scholarly journals Protective effects of citicoline in neonatal rats with necrotizing enterocolitis

2018 ◽  
Vol 3 (1) ◽  
Author(s):  
Shuxia Liang ◽  
Xiaobing Li ◽  
Jie Xu ◽  
Panjian Lai ◽  
Yunguang Bao ◽  
...  
Keyword(s):  
Necrotizing Enterocolitis ◽  
Protective Effects ◽  
Neonatal Rats

scholarly journals 186 Protective Effects of Colchicine in an Experimental Model of Necrotizing Enterocolitis in Neonatal Rat

2012 ◽  
Vol 97 (Suppl 2) ◽  
pp. A53-A54
Author(s):  
S. Yurttutan ◽  
R. Ozdemir ◽  
F. Canpolat ◽  
M. Oncel ◽  
H. Unverdi ◽  
...  
Keyword(s):  
Experimental Model ◽  
Necrotizing Enterocolitis ◽  
Neonatal Rat ◽  
Protective Effects

The protective effects of fecal microbiota transplantation in an experimental model of necrotizing enterocolitis

2019 ◽  
Vol 54 (8) ◽  
pp. 1578-1583 ◽  
Author(s):  
Christian Prado ◽  
Monique Michels ◽  
Pricila Ávila ◽  
Henrique Burger ◽  
Maria Vitória Meller Milioli ◽  
...  
Keyword(s):  
Experimental Model ◽  
Necrotizing Enterocolitis ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Protective Effects

Protective effects of dexpanthenol in an experimental model of necrotizing enterocolitis

2015 ◽  
Vol 50 (7) ◽  
pp. 1119-1124 ◽  
Author(s):  
Ahmet Karadag ◽  
Ramazan Ozdemir ◽  
Ahmet Kurt ◽  
Hakan Parlakpinar ◽  
Alaadin Polat ◽  
...  
Keyword(s):  
Experimental Model ◽  
Necrotizing Enterocolitis ◽  
Protective Effects

Protective effects of hemin in an experimental model of ventilator-induced lung injury

2011 ◽  
Vol 661 (1-3) ◽  
pp. 102-108 ◽  
Author(s):  
Li An ◽  
Chang-Ting Liu ◽  
Xue-Bing Qin ◽  
Qing-Hui Liu ◽  
Yan Liu ◽  
...  
Keyword(s):  
Lung Injury ◽  
Experimental Model ◽  
Protective Effects ◽  
Ventilator Induced Lung Injury

scholarly journals Protective Effects ofN-Acetyl-L-Cysteine in Human Oligodendrocyte Progenitor Cells and Restoration of Motor Function in Neonatal Rats with Hypoxic-Ischemic Encephalopathy

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Dongsun Park ◽  
Kyungha Shin ◽  
Ehn-Kyoung Choi ◽  
Youngjin Choi ◽  
Ja-Young Jang ◽  
...  
Keyword(s):  
White Matter ◽  
Progenitor Cells ◽  
Hypoxic Ischemic Encephalopathy ◽  
Oligodendrocyte Progenitor Cells ◽  
Protective Effects ◽  
Neonatal Rats ◽  
Motor Functions ◽  
Ischemic Encephalopathy

Objective. Since oligodendrocyte progenitor cells (OPCs) are the target cells of neonatal hypoxic-ischemic encephalopathy (HIE), the present study was aimed at investigating the protective effects ofN-acetyl-L-cysteine (NAC), a well-known antioxidant and precursor of glutathione, in OPCs as well as in neonatal rats.Methods. Inin vitrostudy, protective effects of NAC on KCN cytotoxicity in F3.Olig2 OPCs were investigated via MTT assay and apoptotic signal analysis. Inin vivostudy, NAC was administered to rats with HIE induced by hypoxia-ischemia surgery at postnatal day 7, and their motor functions and white matter demyelination were analyzed.Results. NAC decreased KCN cytotoxicity in F3.Olig2 cells and especially suppressed apoptosis by regulating Bcl2 and p-ERK. Administration of NAC recovered motor functions such as the using ratio of forelimb contralateral to the injured brain, locomotor activity, and rotarod performance of neonatal HIE animals. It was also confirmed that NAC attenuated demyelination in the corpus callosum, a white matter region vulnerable to HIE.Conclusion. The results indicate that NAC exerts neuroprotective effectsin vitroandin vivoby preserving OPCs, via regulation of antiapoptotic signaling, and that F3.Olig2 human OPCs could be a good tool for screening of candidates for demyelinating diseases.

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